TY  - JOUR
TI  - Circulating Kisspeptin and Klotho Levels in Women  with Hyperprolactinemia
AB  - Objective: Kisspeptin is a neuropeptide that acts mainly on gonadotropin-releasing hormone in the  hypothalamus with neurokinin B and dynorphin. Also, its peripheral effects have gained importance  in recent years. Klotho is an anti-aging transmembrane glycoprotein with growth hormone and insu lin-like growth factor-1-related effects. Both kisspeptin and klotho seem to interact with prolactin in  the hypothalamic-pituitary region. In this study, we aimed to investigate the relationship between  hyperprolactinemia and circulating kisspeptin and klotho levels. Methods: In this study, 33 women with hyperprolactinemia and 28 control subjects were included.  Blood samples were analyzed for follicle-stimulating hormone, luteinizing hormone, estradiol, pro lactin, α-klotho, kisspeptin, and neurokinin B levels.  Results: There was no difference between the groups in terms of kisspeptin and α-klotho levels  (P =.68 and P =.11, respectively). Follicle-stimulating hormone and estradiol were significantly lower  in the hyperprolactinemia group (P =.02 and P =.03, respectively). Kisspeptin levels were positively  correlated with follicle-stimulating hormone levels (r=0.43, P =.01) and α-klotho levels (r =  0.32,  P =.01). Neurokinin B was negatively correlated with both kisspeptin and α-klotho values (r = −0.42,  P =.01 and r =−0.29, P =.02, respectively). Body mass index was positively correlated with kis speptin and negatively correlated with α-klotho molecule (r = 0.273, P =.03 and r =−0.25, P =.04,  respectively). Conclusion: Hyperprolactinemia does not affect circulating kisspeptin and α-klotho levels but posi tively correlates with kisspeptin and α-klotho, which are known to play a role in complex interactions  between the hypothalamus and the pituitary that may be the subject of new studies in the future.
AU  - bolayır, başak
AU  - yalcin, mehmet muhittin
AU  - Arslan, Ismail Emre
AU  - Ozturk, Beyza Olcay
AU  - YETKİN, İLHAN
AU  - AKTURK, MUJDE
DO  - 10.5152/tjem.2022.22068
PY  - 2022
JO  - Turkish Journal of Endocrinology and Metabolism
VL  - 26
IS  - 3
SN  - 1301-2193
SP  - 115
EP  - 119
DB  - TRDizin
UR  - http://search/yayin/detay/1124134
ER  -