Pregnancy Outcomes of Patients Diagnosed As Having Cleft Lip Or/and Cleft Palate In Antenatal Screening
Yıl: 2022 Cilt: 27 Sayı: 2 Sayfa Aralığı: 204 - 211 Metin Dili: İngilizce DOI: 10.5505/ejm.2022.43765 İndeks Tarihi: 26-09-2022
Pregnancy Outcomes of Patients Diagnosed As Having Cleft Lip Or/and Cleft Palate In Antenatal Screening
Öz: To evaluate the obstetric outcomes of extra ultrasonographic anomalies in patients with cleft lip or/and cleft (CL±P) palate.This retrospective study was conducted in a tertiary referral hospital between December 2017 and March 2021. The patients were analyzed under three groups as follows: isolated CL±P (group 1), CL±P with ultrasonographic anomalies with mild fetal and neonatal consequences (group 2), and CL±P with ultrasonographic anomalies with severe fetal and neonatal consequences (group 3). Fourty cases were analyzed. The abnormal karyotype result (16.7%) were 46,x,t (t15;16)(q26;24), monosomy 18, trisomy 13, 46, XX, 21ps +. In the central cleft, ultrasonographic anomalies were seen in nine patients, which was statistically significantly higher than in isolated CL±P (p=0.004). Seven patients with extra ultrasonographic anomalies underwent termination, one patient with anencephaly died in utero. Preterm birth was the most common obstetric complication in all groups (n=9, 27.2%). In group 3, polyhydramnios was observed statistically significantly more frequently than in group 2 (p=0.033), and the first minute APGAR score was statistically significantly lower than in group 1 and 2 (p=0.003). The fifth minute APGAR score was statistically significantly lower and the need for the neonatal intensive care unit was statistically significantly higher than group 1 only (p=0.004 and p=0.007, respectively). Polyhydramnios is not found in isolated cases, but only in cases with additional anomalies. Patients with CL±P with either major or minor additional ultrasonographic anomalies have worse fifth minute Apgar results and a greater need for the NICU.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- Worley ML, Patel KG, Kilpatrick LA. Cleft Lip and Palate. Clin Perinatol 2018;45(4):661-78.
- Mai CT, Cassell CH, Meyer RE, et al. Birth defects data from population-based birth defects surveillance programs in the United States, 2007 to 2011: highlighting orofacial clefts. Birth Defects Res A Clin Mol Teratol 2014;100(11):895-904.
- Burg ML, Chai Y, Yao CA, Magee W, 3rd, Figueiredo JC. Epidemiology, Etiology, and Treatment of Isolated Cleft Palate. Front Physiol 2016;7:67.
- Calzolari E, Pierini A, Astolfi G, et al. Associated anomalies in multi-malformed infants with cleft lip and palate: An epidemiologic study of nearly 6 million births in 23 EUROCAT registries. Am J Med Genet A 2007;143a(6):528-37.
- Cleft lip and palate. Cited 2021. Available from: https://www.omim.org/search?index=entry&sea rch=cleft+lip+and+palate&start=1&limit=10&re trieve=geneMap&genemap_exists=true.
- De Robertis V, Rembouskos G, Fanelli T, Votino C, Volpe P. Cleft Palate with or without Cleft Lip: The Role of Retronasal Triangle View and Maxillary Gap at 11-14 Weeks. Fetal Diagn Ther 2019;46(6):353-9.
- Marginean C, Sasarean V, Marginean CO, Melit LE, Marginean MO. Prenatal diagnosis of cleft lip and cleft lip palate - a case series. Med Ultrason 2018;20(4):531-5.
- Practice Bulletin No. 175: Ultrasound in Pregnancy. Obstet Gynecol 2016;128(6):e241-e56.
- Salomon LJ, Alfirevic Z, Berghella V, et al. Practice guidelines for performance of the routine mid-trimester fetal ultrasound scan. Ultrasound Obstet Gynecol 2011;37(1):116-26.
- 1Fuchs F, Grosjean F, Captier G, Faure JM. The 2D axial transverse views of the fetal face: A new technique to visualize the fetal hard palate; methodology description and feasibility. Prenat Diagn 2017;37(13):1353-9.
- Brusilov M, Wolman I, Ashwal E, Malinger G, Birnbaum R. Ultrasound imaging of the fetal secondary palate: Methodological description of a two-dimensional approach and a case series. Prenat Diagn 2018;38(13):1049-54.
- Depla AL, Breugem CC, van der Horst CM, et al. Polyhydramnios in isolated oral cleft pregnancies: incidence and outcome in a retrospective study. Prenat Diagn 2017;37(2):162-7.
- Wyszynski DF, Wu T. Prenatal and perinatal factors associated with isolated oral clefting. Cleft Palate Craniofac J 2002;39(3):370-5.
- Zimmerman CE, Folsom N, Humphries LS, et al. What is the Impact of Prenatal Counseling on Postnatal Cleft Treatment? Multidisciplinary Pathway for Prenatal Orofacial Cleft Care. J Craniofac Surg 2021.
- ACOG Practice Bulletin No. 102: management of stillbirth. Obstet Gynecol 2009;113(3):748-61.
- Fetal Growth Restriction: ACOG Practice Bulletin, Number 227. Obstet Gynecol 2021;137(2):e16-e28.
- Martins JG, Biggio JR, Abuhamad A. Society for Maternal-Fetal Medicine Consult Series #52: Diagnosis and management of fetal growth restriction: (Replaces Clinical Guideline Number 3, April 2012). Am J Obstet Gynecol 2020;223(4):B2-b17.
- Dashe JS, Pressman EK, Hibbard JU. SMFM Consult Series #46: Evaluation and management of polyhydramnios. Am J Obstet Gynecol 2018;219(4):B2-b8.
- Dönmez B. TCK’da çocuk düşürtme suçu mukayeseli hukuk ve AİHM’nin bakış açısıyla ceninin yaşama hakkının sınırlandırılması tahlili. 2007;9(2):99-142.
- Hasanzadeh N, Khoda MO, Jahanbin A, Vatankhah M. Coping strategies and psychological distress among mothers of patients with nonsyndromic cleft lip and palate and the family impact of this disorder. J Craniofac Surg 2014;25(2):441-5.
- Wayne C, Cook K, Sairam S, Hollis B, Thilaganathan B. Sensitivity and accuracy of routine antenatal ultrasound screening for isolated facial clefts. Br J Radiol 2002;75(895):584-9.
- Nicholls W, Jennings R, Yeung Y, Walters M, Hewitt B. Antenatal Ultrasound Detection of Cleft in Western Australia from 2003 to 2012: A Follow-Up Study. Cleft Palate Craniofac J 2017;54(3):321-6.
- . Zheng W, Li B, Zou Y, Lou F. The prenatal diagnosis and classification of cleft palate: the role and value of magnetic resonance imaging. Eur Radiol 2019;29(10):5600-6.
- Stroustrup Smith A, Estroff JA, Barnewolt CE, Mulliken JB, Levine D. Prenatal diagnosis of cleft lip and cleft palate using MRI. AJR Am J Roentgenol 2004;183(1):229-35.
- Shi M, Wehby GL, Murray JC. Review on genetic variants and maternal smoking in the etiology of oral clefts and other birth defects. Birth Defects Res C Embryo Today 2008;84(1):16-29.
- Christensen K, Juel K, Herskind AM, Murray JC. Long term follow up study of survival associated with cleft lip and palate at birth. Bmj 2004;328(7453):1405.
- Bäumler M, Faure JM, Bigorre M, et al. Accuracy of prenatal three-dimensional ultrasound in the diagnosis of cleft hard palate when cleft lip is present. Ultrasound Obstet Gynecol 2011;38(4):440-4.
- Olusanya AA, Michael AI, Olawoye OA, Akinmoladun VI. Antenatal Events Amongst Mothers of Babıes Wıth Orofacıal Clefts. Ann Ib Postgrad Med 2020;18(1):S2-s8.
- Gillham JC, Anand S, Bullen PJ. Antenatal detection of cleft lip with or without cleft palate: incidence of associated chromosomal and structural anomalies. Ultrasound Obstet Gynecol 2009;34(4):410-5.
- Bergé SJ, Plath H, Van de Vondel PT, et al. Fetal cleft lip and palate: sonographic diagnosis, chromosomal abnormalities, associated anomalies and postnatal outcome in 70 fetuses. Ultrasound Obstet Gynecol 2001;18(5):422-31.
- Michel B, Debauche C, Hutchings G, et al. Pregnancy and neonatal outcome following an antenatal diagnosis of cleft lip and palate. J Perinat Med 2013;41(3):287-94.
- Guyot A, Soupre V, Vazquez MP, et al. [Prenatal diagnosis of cleft lip with or without cleft palate: retrospective study and review]. J Gynecol Obstet Biol Reprod 2013;42(2):151-8.
| APA | YÜCEL ÇELİK Ö, obut m, Dağdeviren G, keleş A, ÇAYÖNÜ KAHRAMAN N, AYNAOGLU YILDIZ G, Arat Ö, iskender c (2022). Pregnancy Outcomes of Patients Diagnosed As Having Cleft Lip Or/and Cleft Palate In Antenatal Screening. , 204 - 211. 10.5505/ejm.2022.43765 |
| Chicago | YÜCEL ÇELİK ÖZGE,obut mehmet,Dağdeviren Gülşah,keleş Ayşe,ÇAYÖNÜ KAHRAMAN NEVAL,AYNAOGLU YILDIZ GULSAH,Arat Özgür,iskender cantekin Pregnancy Outcomes of Patients Diagnosed As Having Cleft Lip Or/and Cleft Palate In Antenatal Screening. (2022): 204 - 211. 10.5505/ejm.2022.43765 |
| MLA | YÜCEL ÇELİK ÖZGE,obut mehmet,Dağdeviren Gülşah,keleş Ayşe,ÇAYÖNÜ KAHRAMAN NEVAL,AYNAOGLU YILDIZ GULSAH,Arat Özgür,iskender cantekin Pregnancy Outcomes of Patients Diagnosed As Having Cleft Lip Or/and Cleft Palate In Antenatal Screening. , 2022, ss.204 - 211. 10.5505/ejm.2022.43765 |
| AMA | YÜCEL ÇELİK Ö,obut m,Dağdeviren G,keleş A,ÇAYÖNÜ KAHRAMAN N,AYNAOGLU YILDIZ G,Arat Ö,iskender c Pregnancy Outcomes of Patients Diagnosed As Having Cleft Lip Or/and Cleft Palate In Antenatal Screening. . 2022; 204 - 211. 10.5505/ejm.2022.43765 |
| Vancouver | YÜCEL ÇELİK Ö,obut m,Dağdeviren G,keleş A,ÇAYÖNÜ KAHRAMAN N,AYNAOGLU YILDIZ G,Arat Ö,iskender c Pregnancy Outcomes of Patients Diagnosed As Having Cleft Lip Or/and Cleft Palate In Antenatal Screening. . 2022; 204 - 211. 10.5505/ejm.2022.43765 |
| IEEE | YÜCEL ÇELİK Ö,obut m,Dağdeviren G,keleş A,ÇAYÖNÜ KAHRAMAN N,AYNAOGLU YILDIZ G,Arat Ö,iskender c "Pregnancy Outcomes of Patients Diagnosed As Having Cleft Lip Or/and Cleft Palate In Antenatal Screening." , ss.204 - 211, 2022. 10.5505/ejm.2022.43765 |
| ISNAD | YÜCEL ÇELİK, ÖZGE vd. "Pregnancy Outcomes of Patients Diagnosed As Having Cleft Lip Or/and Cleft Palate In Antenatal Screening". (2022), 204-211. https://doi.org/10.5505/ejm.2022.43765 |
| APA | YÜCEL ÇELİK Ö, obut m, Dağdeviren G, keleş A, ÇAYÖNÜ KAHRAMAN N, AYNAOGLU YILDIZ G, Arat Ö, iskender c (2022). Pregnancy Outcomes of Patients Diagnosed As Having Cleft Lip Or/and Cleft Palate In Antenatal Screening. Eastern Journal of Medicine, 27(2), 204 - 211. 10.5505/ejm.2022.43765 |
| Chicago | YÜCEL ÇELİK ÖZGE,obut mehmet,Dağdeviren Gülşah,keleş Ayşe,ÇAYÖNÜ KAHRAMAN NEVAL,AYNAOGLU YILDIZ GULSAH,Arat Özgür,iskender cantekin Pregnancy Outcomes of Patients Diagnosed As Having Cleft Lip Or/and Cleft Palate In Antenatal Screening. Eastern Journal of Medicine 27, no.2 (2022): 204 - 211. 10.5505/ejm.2022.43765 |
| MLA | YÜCEL ÇELİK ÖZGE,obut mehmet,Dağdeviren Gülşah,keleş Ayşe,ÇAYÖNÜ KAHRAMAN NEVAL,AYNAOGLU YILDIZ GULSAH,Arat Özgür,iskender cantekin Pregnancy Outcomes of Patients Diagnosed As Having Cleft Lip Or/and Cleft Palate In Antenatal Screening. Eastern Journal of Medicine, vol.27, no.2, 2022, ss.204 - 211. 10.5505/ejm.2022.43765 |
| AMA | YÜCEL ÇELİK Ö,obut m,Dağdeviren G,keleş A,ÇAYÖNÜ KAHRAMAN N,AYNAOGLU YILDIZ G,Arat Ö,iskender c Pregnancy Outcomes of Patients Diagnosed As Having Cleft Lip Or/and Cleft Palate In Antenatal Screening. Eastern Journal of Medicine. 2022; 27(2): 204 - 211. 10.5505/ejm.2022.43765 |
| Vancouver | YÜCEL ÇELİK Ö,obut m,Dağdeviren G,keleş A,ÇAYÖNÜ KAHRAMAN N,AYNAOGLU YILDIZ G,Arat Ö,iskender c Pregnancy Outcomes of Patients Diagnosed As Having Cleft Lip Or/and Cleft Palate In Antenatal Screening. Eastern Journal of Medicine. 2022; 27(2): 204 - 211. 10.5505/ejm.2022.43765 |
| IEEE | YÜCEL ÇELİK Ö,obut m,Dağdeviren G,keleş A,ÇAYÖNÜ KAHRAMAN N,AYNAOGLU YILDIZ G,Arat Ö,iskender c "Pregnancy Outcomes of Patients Diagnosed As Having Cleft Lip Or/and Cleft Palate In Antenatal Screening." Eastern Journal of Medicine, 27, ss.204 - 211, 2022. 10.5505/ejm.2022.43765 |
| ISNAD | YÜCEL ÇELİK, ÖZGE vd. "Pregnancy Outcomes of Patients Diagnosed As Having Cleft Lip Or/and Cleft Palate In Antenatal Screening". Eastern Journal of Medicine 27/2 (2022), 204-211. https://doi.org/10.5505/ejm.2022.43765 |
