Predictive Factors of Complete Tumor Response to First Line Chemotherapy in Patients with Extensive-stage Small Cell Lung Cancer

iriagac, Yakup; SEBER, SELCUK; Çavdar, Eyyüp; SAKİN, Abdullah

Predictive Factors of Complete Tumor Response to First Line Chemotherapy in Patients with Extensive-stage Small Cell Lung Cancer

Eyyüp ÇAVDAR, (Tekirdağ Namık Kemal University Faculty of Medicine, Department of Medical Oncology, Tekirdağ, Turkey)

Yakup İRİAĞAÇ, (Tekirdağ Namık Kemal University Faculty of Medicine, Department of Medical Oncology, Tekirdağ, Turkey)

Erdoğan Selçuk ŞEBER, (Tekirdağ Namık Kemal University Faculty of Medicine, Department of Medical Oncology, Tekirdağ, Turkey)

Abdullah SAKİN (University of Health Sciences Turkey, Prof. Dr. Cemil Taşcıoğlu City Hospital, Clinic of Medical Oncology, İstanbul, Turkey)

Bağcılar Tıp Bülteni

6 1

Yıl: 2022 Cilt: 7 Sayı: 2 Sayfa Aralığı: 130 - 136 Metin Dili: İngilizce İndeks Tarihi: 26-09-2022

Predictive Factors of Complete Tumor Response to First Line Chemotherapy in Patients with Extensive-stage Small Cell Lung Cancer

Öz:

Objective: We aimed to investigate the factors affecting the complete response (CR) rate and the effect of treatment response on survival in patients with extensive stage-small cell lung cancer (ES-SCLC) who received a combination of cisplatin and etoposide as first-line therapy. Method: This retrospective analysis included 140 ES-SCLC patients, who were followed in an oncology clinic. Patients were divided into two groups as CR and non-CR according to radiological evaluation after first line chemotherapy. Clinical and demographic characteristics and pretreatment hemogram parameters were obtained from electronic medical record system. Results: While CR was seen in 34 (24.3%) of all patients after the first line chemotherapy, 106 (75.7%) patients were in the non-CR group. On univariate analysis, predictors for CR to treatment were the absence of brain metastasis, receiving 6 chemotherapy cycles and good performance status (p<0.001; p=0.020; p=0.001, respectively). In multivariate analysis, the absence of brain metastasis and good performance status were independent predictive factors for CR (p=0.033; p=0.019, respectively). Better treatment response rate to first-line chemotherapy was found to be associated with improved disease-free survival, and overall survival (log-rank p<0.001; log-rank p<0.001, respectively). Conclusion: Good performance status and the absence of brain metastases were identified as independent predictive factors for CR in ES-SCLC patients at the time of diagnosis. Patients who achieved CR had a significantly longer survival rate than patients with lower treatment response.

Anahtar Kelime:

Yaygın Evreli Küçük Hücreli Akciğer Kanseri Tanılı Hastalarda İlk Kemoterapiye Tam Yanıtı Etkileyen Faktörler

Öz:

Amaç: Yaygın evre-küçük hücreli akciğer kanseri (ES-SCLC) tanılı olup, ilk basamakta sisplatin ve etoposid kombinasyon kemoterapisi alan hastalarda tedaviye tam yanıtı (CR) etkileyen faktörleri ve tedaviye yanıt düzeyinin sağkalıma etkisini araştırdık. Yöntem: Bu retrospektif çalışmada ES-SCLC tanılı 140 hasta incelendi. İlk basamak kemoterapi sonrası radyolojik yanıt değerlendirmesine göre CR ve CR olmayan (non-CR) olarak iki grup belirlendi. Klinik, demografik hasta özellikleri ve tedavi öncesi hemogram parametreleri arşivden elde edildi. Bulgular: Hastaların 34’ü (%24,3) CR, 106 (%75,7) hasta non-CR grubunda yer aldı. Yapılan tek değişkenli analizde tanı anında beyin metastazı yokluğu, 6 kemoterapi siklusu alma ve iyi performans durumu CR için öngörücü faktörler olarak bulundu (sırasıyla p<0,001; p=0,020; p=0,001). Çok değişkenli analizde ise beyin metastaz yokluğu ve iyi performans durumu CR için bağımsız prediktif faktörler olarak saptandı (sırasıyla p=0,033; p=0,019). Ayrıca birinci basamak kemoterapiye verilen yanıt arttıkça hastalıksız sağkalım süresi ve genel sağkalım süresinin uzadığı tespit edildi (sırasıyla log-rank p<0,001; log-rank p<0,001). Sonuç: Tanı anında beyin metastaz yokluğu ve iyi performans durumu birinci basamak tedaviye tam yanıt için bağımsız prediktif faktörlerdir. Tam yanıta ulaşan hastalar, daha düşük tedavi yanıtına göre önemli ölçüde daha uzun sağkalıma sahiptir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Çavdar E, iriagac Y, SEBER S, SAKİN A (2022). Predictive Factors of Complete Tumor Response to First Line Chemotherapy in Patients with Extensive-stage Small Cell Lung Cancer. , 130 - 136.
Chicago	Çavdar Eyyüp,iriagac Yakup,SEBER SELCUK,SAKİN Abdullah Predictive Factors of Complete Tumor Response to First Line Chemotherapy in Patients with Extensive-stage Small Cell Lung Cancer. (2022): 130 - 136.
MLA	Çavdar Eyyüp,iriagac Yakup,SEBER SELCUK,SAKİN Abdullah Predictive Factors of Complete Tumor Response to First Line Chemotherapy in Patients with Extensive-stage Small Cell Lung Cancer. , 2022, ss.130 - 136.
AMA	Çavdar E,iriagac Y,SEBER S,SAKİN A Predictive Factors of Complete Tumor Response to First Line Chemotherapy in Patients with Extensive-stage Small Cell Lung Cancer. . 2022; 130 - 136.
Vancouver	Çavdar E,iriagac Y,SEBER S,SAKİN A Predictive Factors of Complete Tumor Response to First Line Chemotherapy in Patients with Extensive-stage Small Cell Lung Cancer. . 2022; 130 - 136.
IEEE	Çavdar E,iriagac Y,SEBER S,SAKİN A "Predictive Factors of Complete Tumor Response to First Line Chemotherapy in Patients with Extensive-stage Small Cell Lung Cancer." , ss.130 - 136, 2022.
ISNAD	Çavdar, Eyyüp vd. "Predictive Factors of Complete Tumor Response to First Line Chemotherapy in Patients with Extensive-stage Small Cell Lung Cancer". (2022), 130-136.

APA	Çavdar E, iriagac Y, SEBER S, SAKİN A (2022). Predictive Factors of Complete Tumor Response to First Line Chemotherapy in Patients with Extensive-stage Small Cell Lung Cancer. Bağcılar Tıp Bülteni, 7(2), 130 - 136.
Chicago	Çavdar Eyyüp,iriagac Yakup,SEBER SELCUK,SAKİN Abdullah Predictive Factors of Complete Tumor Response to First Line Chemotherapy in Patients with Extensive-stage Small Cell Lung Cancer. Bağcılar Tıp Bülteni 7, no.2 (2022): 130 - 136.
MLA	Çavdar Eyyüp,iriagac Yakup,SEBER SELCUK,SAKİN Abdullah Predictive Factors of Complete Tumor Response to First Line Chemotherapy in Patients with Extensive-stage Small Cell Lung Cancer. Bağcılar Tıp Bülteni, vol.7, no.2, 2022, ss.130 - 136.
AMA	Çavdar E,iriagac Y,SEBER S,SAKİN A Predictive Factors of Complete Tumor Response to First Line Chemotherapy in Patients with Extensive-stage Small Cell Lung Cancer. Bağcılar Tıp Bülteni. 2022; 7(2): 130 - 136.
Vancouver	Çavdar E,iriagac Y,SEBER S,SAKİN A Predictive Factors of Complete Tumor Response to First Line Chemotherapy in Patients with Extensive-stage Small Cell Lung Cancer. Bağcılar Tıp Bülteni. 2022; 7(2): 130 - 136.
IEEE	Çavdar E,iriagac Y,SEBER S,SAKİN A "Predictive Factors of Complete Tumor Response to First Line Chemotherapy in Patients with Extensive-stage Small Cell Lung Cancer." Bağcılar Tıp Bülteni, 7, ss.130 - 136, 2022.
ISNAD	Çavdar, Eyyüp vd. "Predictive Factors of Complete Tumor Response to First Line Chemotherapy in Patients with Extensive-stage Small Cell Lung Cancer". Bağcılar Tıp Bülteni 7/2 (2022), 130-136.