Early Diagnosis of Diabetes Mellitus by Machine Learning Methods According to Plasma Glucose Concentration, Serum Insulin Resistance and Diastolic Blood Pressure Indicators

Yıl: 2022 Cilt: 4 Sayı: 2 Sayfa Aralığı: 191 - 195 Metin Dili: İngilizce DOI: 10.37990/medr.1021148 İndeks Tarihi: 27-09-2022

Early Diagnosis of Diabetes Mellitus by Machine Learning Methods According to Plasma Glucose Concentration, Serum Insulin Resistance and Diastolic Blood Pressure Indicators

Öz:
Aim: It is a known fact that diabetes mellitus is increasing frequently and triggering many different diseases. Therefore, early diagnosis of the disease is important. This study was trying to predict the early diagnosis of the disease, according to machine learning methods by measuring plasma glucose concentration, serum insulin resistance, and diastolic blood pressure.Material and Methods: In the study, the public dataset from a website consists of 768 samples and nine variables. Three different machine learning strategies were used in the early diagnosis of diabetes mellitus (Support Vector Machine, Multilayer Perceptron, and Stochastic Gradient Boosting). 3 repeats and 10 fold cross-validation method was used to optimize the hyperparameters. The model’s performance parameters were evaluated based on accuracy, specificity, sensitivity, confusion matrix, positive predictive value (precision), negative predictive value, and AUC (area under the ROC curve).Results: According to the experimental results (the criteria of accuracy (0.79), sensitivity (0.57), specificity (0.91), positive predictive value (0.79), negative predictive value (0.80), and AUC (0.74)) the Support Vector Machine was more successful than other methods.Conclusion: Plasma glucose concentration, serum insulin resistance, and diastolic blood pressure markers are important indicators in the early diagnosis of diabetes mellitus. In this study, it was seen that these markers make a significant contribution to the early diagnosis of diabetes mellitus. However, it has been observed that these indicators alone will not be sufficient in the early diagnosis of the disease, especially since age, body mass index and pregnancy contribute significantly. 
Anahtar Kelime: Diabetes Mellitus Plasma Glucose Concentration Serum Insulin Resistance Diastolic Blood Pressure Machine Learning

Plazma Glukoz Konsantrasyonu, Serum Insülin Direnci ve Diastolik Kan Basıncı Göstergeleri ile Makine Öğrenme Yöntemleri Kullanılarak Diyabet Hastalığının Erken Tanısı

Öz:
Amaç: Diyabetin sıklıkla arttığı ve bir çok farklı hastalığı tetiklediği bilinen bir gerçektir. Bu nedenle hastalığın erken teşhisi önemlidir. Bu çalışmada plazma glukoz konsantrasyonu, serum insülin direnci ve diyastolik kan basıncı göstergelerinden, makine öğrenmesi yöntemlerine göre hastalığın erken teşhisi öngörülmeye çalışılmıştır.Materyal ve Metot: Çalışmada, bir web sitesinden alınan halka açık veri seti 768 örnek ve dokuz değişkenden oluşmaktadır. Diyabetin erken teşhisinde üç farklı makine öğrenme stratejisi kullanıldı (Destek Vektör Makineleri, Çok Katmanlı Algılayıcılar ve Stokastik Gradyan Artırma). Hiper parametre optimizasyonu için 3 tekrarlı 10 kat tekrarlı çapraz doğrulama yöntemi kullanıldı. Modellerin performansı doğruluk, seçicilik, duyarlılık, karışıklık matrisi, pozitif tahmin değeri (kesinlik), negatif tahmin değeri ve AUC (ROC eğrisi altında kalan alan) temel alınarak değerlendirilmiştir.Bulgular: Deneysel sonuçlara göre (doğruluk (0.79), duyarlılık (0.57), özgüllük (0.91), pozitif tahmin değeri (0.79), negatif tahmin değeri (0.80) ve AUC (0.74) kriterleri), Destek Vektör Makineleri diğer yöntemlere göre daha başarılı çıkmıştır.Sonuç: Diyabet hastalığının erken tanısında plazma glukoz konsantrasyonu, serum insülin direnci ve diastolik kan basinci belirteçleri önemli göstergelerdir. Bu çalışmada da bu belirteçlerin diyabetin erken tanısında önemli katkı sağladığı görülmüştür. Ancak tek başlarına bu göstergelerin hastalığın erken tanısında yeterli olmayacağı özellikle yaş, beden kitle indeksi ve gebeliğin de önemli derecede katkı sağladığı görülmüştür. 
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Said G. Diabetic neuropathy-A Review. Nat Clin Prac Neurol. 2007;3:331-40.
  • 2. Albers JW. Diabetic Neuropathy: Mechanisms, emerging treatment,s and subtypes. Curr Neurol Neurosci Rep. 2014;14:473.
  • 3. Charnogursky G. Neurological complications of diabetes. Curr Neurol Neurosci Rep. 2014;14:457.
  • 4. Prima Indians Diabetes Database (PIDD), ttps://www. kaggle.com/saurabh00007/diabetescsv access date 11.05.2021
  • 5. Platt J. Probabilistic outputs for support vector machines and comparisons to regularized likelihood methods. Advances in Large Margin Classifiers. 1999;10:61-74.6.
  • 6. Birjandi SM, Khasteh SH. A survey on data mining techniques used in medicine. J Diabetes Metab Disord. 2021;20:2055- 71.
  • 7. Nitze I, Schulthess U, Asche H. Comparison of machine learning algorithms random forest, artificial neural network and support vector machine the o maximum likelihood for supervised crop type classification. Proc of the 4th GEOBIA 2012, p. 35.
  • 8. Cortes C, Vapnik V. Support-vector networks. Machine Learning. 1995;20:273-97.
  • 9. Ayhan S, Erdogmus S. Kernel function selection for solving classification problems with support vector machines. Eskisehir Osmangazi University. Journal of economics and administrative sciences. 2014;9:175-201.
  • 10. Arslan A, Sen B. Detection of non-coding RNA’s with optimized support vector machines. 23nd Signal Processing and Communications Applications Conference (SIU) IEEE. 2015:1668-71.
  • 11. Schapire RE. The boosting approach to machine learning: an overview, nonlinear estimation and classification. Springer. 2003, p.149-71.
  • 12. Friedman JH. Stochastic gradient boosting Comput. Stat Data Anal. 2002;38:367-78.
  • 13. Ridgeway G. Generalized Boosted Regression Models: A guide to the gbm package. Update, 2007;1.
  • 14. Rosenblatt, F. Two theorems of statistical separability in the perceptron. United States Department of Commerce. 1958.
  • 15. Yasar S, Arslan A, Colak C. et al. A Developed Interactive Web Application for Statistical Analysis: Statistical Analysis Software. Middle Black Sea J Health Science. 2020;2:227- 39.
  • 16. Campbell, M. RStudio Projects. In Learn RStudio IDE. 2019, p. 39-48.
  • 17. Sarwar MA, Kamal N, Hamid W, et al. Prediction of Diabetes Using Machine Learning Algorithm. ICAC - IEEE. 2018: p. 1-6.
  • 18. Riihimaa, P. Impact of machine learning and feature selection on type 2 diabetes risk prediction. J Med Artif Intell. 2020;3:20-4.
  • 19. Islam MA, Jahan N . Prediction of onset diabetes using machine learning techniques. Int J Computer Applications. 2017;180:7-11.
APA KIVRAK M (2022). Early Diagnosis of Diabetes Mellitus by Machine Learning Methods According to Plasma Glucose Concentration, Serum Insulin Resistance and Diastolic Blood Pressure Indicators. , 191 - 195. 10.37990/medr.1021148
Chicago KIVRAK MEHMET Early Diagnosis of Diabetes Mellitus by Machine Learning Methods According to Plasma Glucose Concentration, Serum Insulin Resistance and Diastolic Blood Pressure Indicators. (2022): 191 - 195. 10.37990/medr.1021148
MLA KIVRAK MEHMET Early Diagnosis of Diabetes Mellitus by Machine Learning Methods According to Plasma Glucose Concentration, Serum Insulin Resistance and Diastolic Blood Pressure Indicators. , 2022, ss.191 - 195. 10.37990/medr.1021148
AMA KIVRAK M Early Diagnosis of Diabetes Mellitus by Machine Learning Methods According to Plasma Glucose Concentration, Serum Insulin Resistance and Diastolic Blood Pressure Indicators. . 2022; 191 - 195. 10.37990/medr.1021148
Vancouver KIVRAK M Early Diagnosis of Diabetes Mellitus by Machine Learning Methods According to Plasma Glucose Concentration, Serum Insulin Resistance and Diastolic Blood Pressure Indicators. . 2022; 191 - 195. 10.37990/medr.1021148
IEEE KIVRAK M "Early Diagnosis of Diabetes Mellitus by Machine Learning Methods According to Plasma Glucose Concentration, Serum Insulin Resistance and Diastolic Blood Pressure Indicators." , ss.191 - 195, 2022. 10.37990/medr.1021148
ISNAD KIVRAK, MEHMET. "Early Diagnosis of Diabetes Mellitus by Machine Learning Methods According to Plasma Glucose Concentration, Serum Insulin Resistance and Diastolic Blood Pressure Indicators". (2022), 191-195. https://doi.org/10.37990/medr.1021148
APA KIVRAK M (2022). Early Diagnosis of Diabetes Mellitus by Machine Learning Methods According to Plasma Glucose Concentration, Serum Insulin Resistance and Diastolic Blood Pressure Indicators. Medical records-international medical journal (Online), 4(2), 191 - 195. 10.37990/medr.1021148
Chicago KIVRAK MEHMET Early Diagnosis of Diabetes Mellitus by Machine Learning Methods According to Plasma Glucose Concentration, Serum Insulin Resistance and Diastolic Blood Pressure Indicators. Medical records-international medical journal (Online) 4, no.2 (2022): 191 - 195. 10.37990/medr.1021148
MLA KIVRAK MEHMET Early Diagnosis of Diabetes Mellitus by Machine Learning Methods According to Plasma Glucose Concentration, Serum Insulin Resistance and Diastolic Blood Pressure Indicators. Medical records-international medical journal (Online), vol.4, no.2, 2022, ss.191 - 195. 10.37990/medr.1021148
AMA KIVRAK M Early Diagnosis of Diabetes Mellitus by Machine Learning Methods According to Plasma Glucose Concentration, Serum Insulin Resistance and Diastolic Blood Pressure Indicators. Medical records-international medical journal (Online). 2022; 4(2): 191 - 195. 10.37990/medr.1021148
Vancouver KIVRAK M Early Diagnosis of Diabetes Mellitus by Machine Learning Methods According to Plasma Glucose Concentration, Serum Insulin Resistance and Diastolic Blood Pressure Indicators. Medical records-international medical journal (Online). 2022; 4(2): 191 - 195. 10.37990/medr.1021148
IEEE KIVRAK M "Early Diagnosis of Diabetes Mellitus by Machine Learning Methods According to Plasma Glucose Concentration, Serum Insulin Resistance and Diastolic Blood Pressure Indicators." Medical records-international medical journal (Online), 4, ss.191 - 195, 2022. 10.37990/medr.1021148
ISNAD KIVRAK, MEHMET. "Early Diagnosis of Diabetes Mellitus by Machine Learning Methods According to Plasma Glucose Concentration, Serum Insulin Resistance and Diastolic Blood Pressure Indicators". Medical records-international medical journal (Online) 4/2 (2022), 191-195. https://doi.org/10.37990/medr.1021148