Aim: This study was conducted using a prospective randomized single-blind clinical trial model to examine the effect of neuro-linguistic programming (NLP) on depression, anxiety, and stress in liver transplant patients.Materials and Methods: This study was conducted with liver transplant patients at a university’s Liver Transplant Institute between June 2021 and December 2021. The sample size of the study was determined as 84 (Experimental group: 42, control group: 42). Personal information form and Depression, Anxiety, and Stress Scale (DASS-21) were used to collect data. The data obtained from the research were evaluated with SPSS 25.Results: In the experimental group, the mean score of DASS-21 was found to be 38.95 ± 11.96 before the NLP application and 25.21 ± 5.43 after the NLP application. It was found statistically significant that the value obtained in the second measurement was lower than the value obtained in the first measurement (p<0.05). It was determined that NLP application significantly decreased all parameters of depression, anxiety, and stress (p<0.05). In the control group, the mean score of DASS-21 was determined as 51.05 ± 7.53 in the first measurement and 52.57 ± 7.92 in the second measurement. It was found statistically significant that the value obtained in the second measurement was higher than the value obtained in the first measurement (p<0.05).Conclusion: This study found that NLP reduced depression, anxiety, and stress in liver transplant patients. In line with this result, it can be suggested that nurse’s benefit from NLP practice and receive training on NLP in managing the depression, anxiety, and stress experienced by liver transplant patients.