Evaluation of Health Status and Quality of Life in Patients Using Intravenous and Subcutaneous Forms of Immunoglobulin Replacement
Yıl: 2022 Cilt: 75 Sayı: 1 Sayfa Aralığı: 77 - 83 Metin Dili: İngilizce DOI: 10.4274/atfm.galenos.2022.55476 İndeks Tarihi: 28-09-2022
Evaluation of Health Status and Quality of Life in Patients Using Intravenous and Subcutaneous Forms of Immunoglobulin Replacement
Öz: Objectives: Health-related quality of life (HRQoL) is an emerging field of research in primary immunodeficiency (PID) patients. PID patients’ quality of life worsens as a result of their considerable disease load causing limited capacity to work and attend school, as well as participation in routine physical activities. The aim of this study was to analyze the demographics, treatment satisfaction, treatment-related side effects, health status and HRQoL of adult PID patients using different immunoglobulin replacement methods. Materials and Methods: In this prospective, cross-sectional research, 53 adult patients, who had been diagnosed with PID and treated with IgRT, were included. The Euro-QOL 5-D (EQ-5D) and Medical Outcomes Study Short Form-36 (SF-36) scales were used to evaluate health status and HRQoL. Results: The study included 53 patients with a median age of 32 (IQR: 24-45) years. Thirty-three (62.2%) patients were female. Twenty-three individuals received intravenous immunoglobulin (IVIG) and 30 subcutaneous immunoglobulin (SCIG). There was no significant difference in side effects between SCIG and IVIG. According to the EQ-5D results, anxiety/depression was the most problematic area to deal with. Patients’ median SF-36 scores were significantly lower (p<0.005) than healthy Turkish population norms in all categories (except for mental health). For physical functioning, physical role difficulty, emotional role difficulty, and vitality, the median scores of the SCIG group were similar to those of the healthy population. Conclusion: Given that individuals receiving SCIG therapy have a comparable quality of life as the general population, employing SCIG in appropriate and chosen patients may improve quality of life by allowing patients to be more independent. Patients with PIDs should have regular HRQoL assessments to ensure that they are receiving sufficient psychosocial care.
Anahtar Kelime: İntravenöz ve Subkütan İmmünoglobulin Replasman Tedavisi Kullanan Hastalarda Sağlık Durumu ve Yaşam Kalitesinin Değerlendirilmesi
Öz: Amaç: Sağlık ilişkili yaşam kalitesi (HRQoL), primer immün yetmezlik (PİY) hastalarında giderek daha çok araştırılan bir konu olarak karşımıza çıkmaktadır. PİY’lere bağlı ortaya çıkan önemli hastalık yükü hastaların çalışma ve okul hayatına dahil olma, rutin fiziksel aktivitelere katılımını olumsuz olarak etkileyerek yaşam kalitelerini düşürmektedir. Bu çalışma ile farklı immünoglobulin replasman tedavisi (IgRT) formlarını kullanan yetişkin PİY hastalarının demografik özelliklerini, tedavi memnuniyetini, tedaviye bağlı yan etkileri, sağlık durumunu ve yaşam kalitesini değerlendirmek amaçlanmıştır. Gereç ve Yöntem: Bu prospektif, kesitsel araştırmaya, PİY tanısı ile takip edilen ve IgRT alan 53 erişkin hasta dahil edilmiştir. Sağlık durumunu ve yaşam kalitesini değerlendirmek için Euro-QOL 5-D (EQ-5D) ve Medical Outcomes Study Short Form-36 (SF-36) ölçeklerinin Türkçe versiyonları kullanıldı. Bulgular: Çalışmaya medyan yaşı 32 (IQR: 24-45) olan 53 hasta dahil edildi. Otuz üç (%62,2) hasta kadındı. Yirmi üç kişiye intravenöz immünogülobin (IVIG) ve 30 subkütan immünoglobulin (SCIG) verildi. SCIG ve IVIG arasında yan etkiler açısından anlamlı bir fark yoktu. EQ-5D sonuçlarına göre kaygı/depresyon en sorunlu alandı. Hastaların medyan SF-36 puanları, tüm kategorilerde (ruh sağlığı hariç) sağlıklı Türk popülasyonu normlarından anlamlı derecede düşüktü (p<0,005). Fiziksel işlevsellik, fiziksel rol güçlüğü, duygusal rol güçlüğü ve canlılık için SCIG grubu medyan puanları sağlıklı popülasyona benzerdi. Sonuç: SCIG tedavisi alan bireylerin genel popülasyonla benzer bir yaşam kalitesine sahip olduğu göz önüne alındığında, uygun ve seçilmiş hastalarda SCIG kullanılması, hastaların daha bağımsız olmasına izin vererek yaşam kalitesini iyileştirebilir. PİY’li hastalarda, yaşam kalitesi düzenli olarak değerlendirilmeli ve yeterli psikososyal bakım sağlanmalıdır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Esenboğa S, Akarsu A, bildik h, Çağdaş D, Tezcan İ (2022). Evaluation of Health Status and Quality of Life in Patients Using Intravenous and Subcutaneous Forms of Immunoglobulin Replacement. , 77 - 83. 10.4274/atfm.galenos.2022.55476 |
| Chicago | Esenboğa Saliha,Akarsu Aysegul,bildik hacer neslihan,Çağdaş Deniz,Tezcan İlhan Evaluation of Health Status and Quality of Life in Patients Using Intravenous and Subcutaneous Forms of Immunoglobulin Replacement. (2022): 77 - 83. 10.4274/atfm.galenos.2022.55476 |
| MLA | Esenboğa Saliha,Akarsu Aysegul,bildik hacer neslihan,Çağdaş Deniz,Tezcan İlhan Evaluation of Health Status and Quality of Life in Patients Using Intravenous and Subcutaneous Forms of Immunoglobulin Replacement. , 2022, ss.77 - 83. 10.4274/atfm.galenos.2022.55476 |
| AMA | Esenboğa S,Akarsu A,bildik h,Çağdaş D,Tezcan İ Evaluation of Health Status and Quality of Life in Patients Using Intravenous and Subcutaneous Forms of Immunoglobulin Replacement. . 2022; 77 - 83. 10.4274/atfm.galenos.2022.55476 |
| Vancouver | Esenboğa S,Akarsu A,bildik h,Çağdaş D,Tezcan İ Evaluation of Health Status and Quality of Life in Patients Using Intravenous and Subcutaneous Forms of Immunoglobulin Replacement. . 2022; 77 - 83. 10.4274/atfm.galenos.2022.55476 |
| IEEE | Esenboğa S,Akarsu A,bildik h,Çağdaş D,Tezcan İ "Evaluation of Health Status and Quality of Life in Patients Using Intravenous and Subcutaneous Forms of Immunoglobulin Replacement." , ss.77 - 83, 2022. 10.4274/atfm.galenos.2022.55476 |
| ISNAD | Esenboğa, Saliha vd. "Evaluation of Health Status and Quality of Life in Patients Using Intravenous and Subcutaneous Forms of Immunoglobulin Replacement". (2022), 77-83. https://doi.org/10.4274/atfm.galenos.2022.55476 |
| APA | Esenboğa S, Akarsu A, bildik h, Çağdaş D, Tezcan İ (2022). Evaluation of Health Status and Quality of Life in Patients Using Intravenous and Subcutaneous Forms of Immunoglobulin Replacement. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 75(1), 77 - 83. 10.4274/atfm.galenos.2022.55476 |
| Chicago | Esenboğa Saliha,Akarsu Aysegul,bildik hacer neslihan,Çağdaş Deniz,Tezcan İlhan Evaluation of Health Status and Quality of Life in Patients Using Intravenous and Subcutaneous Forms of Immunoglobulin Replacement. Ankara Üniversitesi Tıp Fakültesi Mecmuası 75, no.1 (2022): 77 - 83. 10.4274/atfm.galenos.2022.55476 |
| MLA | Esenboğa Saliha,Akarsu Aysegul,bildik hacer neslihan,Çağdaş Deniz,Tezcan İlhan Evaluation of Health Status and Quality of Life in Patients Using Intravenous and Subcutaneous Forms of Immunoglobulin Replacement. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol.75, no.1, 2022, ss.77 - 83. 10.4274/atfm.galenos.2022.55476 |
| AMA | Esenboğa S,Akarsu A,bildik h,Çağdaş D,Tezcan İ Evaluation of Health Status and Quality of Life in Patients Using Intravenous and Subcutaneous Forms of Immunoglobulin Replacement. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2022; 75(1): 77 - 83. 10.4274/atfm.galenos.2022.55476 |
| Vancouver | Esenboğa S,Akarsu A,bildik h,Çağdaş D,Tezcan İ Evaluation of Health Status and Quality of Life in Patients Using Intravenous and Subcutaneous Forms of Immunoglobulin Replacement. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2022; 75(1): 77 - 83. 10.4274/atfm.galenos.2022.55476 |
| IEEE | Esenboğa S,Akarsu A,bildik h,Çağdaş D,Tezcan İ "Evaluation of Health Status and Quality of Life in Patients Using Intravenous and Subcutaneous Forms of Immunoglobulin Replacement." Ankara Üniversitesi Tıp Fakültesi Mecmuası, 75, ss.77 - 83, 2022. 10.4274/atfm.galenos.2022.55476 |
| ISNAD | Esenboğa, Saliha vd. "Evaluation of Health Status and Quality of Life in Patients Using Intravenous and Subcutaneous Forms of Immunoglobulin Replacement". Ankara Üniversitesi Tıp Fakültesi Mecmuası 75/1 (2022), 77-83. https://doi.org/10.4274/atfm.galenos.2022.55476 |
