TY  - JOUR
TI  - Evaluation of Health Status and Quality of Life in Patients  Using Intravenous and Subcutaneous Forms of Immunoglobulin  Replacement
AB  - Objectives: Health-related quality of life (HRQoL) is an emerging field of research in primary immunodeficiency (PID) patients. PID patients’ quality  of life worsens as a result of their considerable disease load causing limited capacity to work and attend school, as well as participation in routine  physical activities. The aim of this study was to analyze the demographics, treatment satisfaction, treatment-related side effects, health status and  HRQoL of adult PID patients using different immunoglobulin replacement methods. Materials and Methods: In this prospective, cross-sectional research, 53 adult patients, who had been diagnosed with PID and treated with IgRT,  were included. The Euro-QOL 5-D (EQ-5D) and Medical Outcomes Study Short Form-36 (SF-36) scales were used to evaluate health status and  HRQoL. Results: The study included 53 patients with a median age of 32 (IQR: 24-45) years. Thirty-three (62.2%) patients were female. Twenty-three  individuals received intravenous immunoglobulin (IVIG) and 30 subcutaneous immunoglobulin (SCIG). There was no significant difference in side  effects between SCIG and IVIG. According to the EQ-5D results, anxiety/depression was the most problematic area to deal with. Patients’ median  SF-36 scores were significantly lower (p<0.005) than healthy Turkish population norms in all categories (except for mental health). For physical  functioning, physical role difficulty, emotional role difficulty, and vitality, the median scores of the SCIG group were similar to those of the healthy  population. Conclusion: Given that individuals receiving SCIG therapy have a comparable quality of life as the general population, employing SCIG in appropriate  and chosen patients may improve quality of life by allowing patients to be more independent. Patients with PIDs should have regular HRQoL  assessments to ensure that they are receiving sufficient psychosocial care.
AU  - Tezcan, İlhan
AU  - Akarsu, Aysegul
AU  - bildik, hacer neslihan
AU  - Çağdaş, Deniz
AU  - Esenboğa, Saliha
DO  - 10.4274/atfm.galenos.2022.55476
PY  - 2022
JO  - Ankara Üniversitesi Tıp Fakültesi Mecmuası
VL  - 75
IS  - 1
SN  - 0365-8104
SP  - 77
EP  - 83
DB  - TRDizin
UR  - http://search/yayin/detay/1125255
ER  -