Brain in metabolic syndrome model: The effect of exercises and caloric restriction

Burcin ALEV-TUZUNER, (İstanbul Gelişim Üniversitesi Diş Hekimliği Fakültesi Temel Tıp Bilimleri Anabilim Dalı, İstanbul, Türkiye)
Nevin GENC-KAHRAMAN, (Bursa Halk Sağlığı Laboratuvarı, Tıbbi Biyokimya, Bursa, Türkiye)
Hazal IPEKCI, (Marmara Üniversitesi Diş Hekimliği Fakültesi, Temel Tıp Bilimleri Anabilim Dalı, İstanbul, Türkiye)
Unsal Veli USTUNDAG, (Marmara Üniversitesi Diş Hekimliği Fakültesi, Temel Tıp Bilimleri Anabilim Dalı, İstanbul, Türkiye)
Tugba TUNALI AKBAY, (Marmara Üniversitesi Diş Hekimliği Fakültesi, Temel Tıp Bilimleri Anabilim Dalı, İstanbul, Türkiye)
Ebru EMEKLI ALTURFAN, (Marmara Üniversitesi Diş Hekimliği Fakültesi, Temel Tıp Bilimleri Anabilim Dalı, İstanbul, Türkiye)
Goksel SENER, (Fenerbahçe Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, İstanbul, Türkiye)
Aysen YARAT (Marmara Üniversitesi Diş Hekimliği Fakültesi, Temel Tıp Bilimleri Anabilim Dalı, İstanbul, Türkiye)
Journal of research in pharmacy (online)
2 0
Yıl: 2022 Cilt: 26 Sayı: 5 Sayfa Aralığı: 1352 - 1362 Metin Dili: İngilizce DOI: 10.29228/jrp.227 İndeks Tarihi: 29-09-2022

Brain in metabolic syndrome model: The effect of exercises and caloric restriction

Öz:
Caloric restriction (CR) and exercise (EX) have impacts on improving metabolic risk factors. This study aimed to investigate the changes in the brain after EX and/or CR in metabolic syndrome (MeS) induced by a high fructose diet in rats. Sprague-Dawley male rats were divided into five groups. Drinking water including 10% fructose solution was given to rats for 12 weeks to develop a MeS rat model. Animals with MeS were submitted to EX and/or CR for 6 weeks. Blood glucose, and brain tissue damage and antioxidant parameters were measured. Brain lipid peroxidation, sialic acid, mucin, fucose levels increased in the MeS group compared to the control (C) group. These parameters reduced significantly in the metabolic syndrome with caloric restriction (MeS+CR) group, and more significantly in the metabolic syndrome with exercise and caloric restriction group (MeS+EXCR), compared to the MeS group. Glutathione levels, superoxide dismutase and catalase activities decreased in the MeS group compared to the C group, increased both in the MeS+CR group, and MeS+EXCR group compared to the MeS group. High fructose diet consumption can lead to brain tissue damage and decreased antioxidant levels were found to be improved best in the MeS+EXCR group.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA ALEV-TUZUNER B, GENC-KAHRAMAN N, IPEKCI H, USTUNDAG U, AKBAY T, ALTURFAN E, SENER G, YARAT A (2022). Brain in metabolic syndrome model: The effect of exercises and caloric restriction. , 1352 - 1362. 10.29228/jrp.227
Chicago ALEV-TUZUNER Burcin,GENC-KAHRAMAN Nevin,IPEKCI Hazal,USTUNDAG Unsal Veli,AKBAY Tugba Tunalı,ALTURFAN Ebru EMEKLI,SENER Goksel,YARAT Aysen Brain in metabolic syndrome model: The effect of exercises and caloric restriction. (2022): 1352 - 1362. 10.29228/jrp.227
MLA ALEV-TUZUNER Burcin,GENC-KAHRAMAN Nevin,IPEKCI Hazal,USTUNDAG Unsal Veli,AKBAY Tugba Tunalı,ALTURFAN Ebru EMEKLI,SENER Goksel,YARAT Aysen Brain in metabolic syndrome model: The effect of exercises and caloric restriction. , 2022, ss.1352 - 1362. 10.29228/jrp.227
AMA ALEV-TUZUNER B,GENC-KAHRAMAN N,IPEKCI H,USTUNDAG U,AKBAY T,ALTURFAN E,SENER G,YARAT A Brain in metabolic syndrome model: The effect of exercises and caloric restriction. . 2022; 1352 - 1362. 10.29228/jrp.227
Vancouver ALEV-TUZUNER B,GENC-KAHRAMAN N,IPEKCI H,USTUNDAG U,AKBAY T,ALTURFAN E,SENER G,YARAT A Brain in metabolic syndrome model: The effect of exercises and caloric restriction. . 2022; 1352 - 1362. 10.29228/jrp.227
IEEE ALEV-TUZUNER B,GENC-KAHRAMAN N,IPEKCI H,USTUNDAG U,AKBAY T,ALTURFAN E,SENER G,YARAT A "Brain in metabolic syndrome model: The effect of exercises and caloric restriction." , ss.1352 - 1362, 2022. 10.29228/jrp.227
ISNAD ALEV-TUZUNER, Burcin vd. "Brain in metabolic syndrome model: The effect of exercises and caloric restriction". (2022), 1352-1362. https://doi.org/10.29228/jrp.227
APA ALEV-TUZUNER B, GENC-KAHRAMAN N, IPEKCI H, USTUNDAG U, AKBAY T, ALTURFAN E, SENER G, YARAT A (2022). Brain in metabolic syndrome model: The effect of exercises and caloric restriction. Journal of research in pharmacy (online), 26(5), 1352 - 1362. 10.29228/jrp.227
Chicago ALEV-TUZUNER Burcin,GENC-KAHRAMAN Nevin,IPEKCI Hazal,USTUNDAG Unsal Veli,AKBAY Tugba Tunalı,ALTURFAN Ebru EMEKLI,SENER Goksel,YARAT Aysen Brain in metabolic syndrome model: The effect of exercises and caloric restriction. Journal of research in pharmacy (online) 26, no.5 (2022): 1352 - 1362. 10.29228/jrp.227
MLA ALEV-TUZUNER Burcin,GENC-KAHRAMAN Nevin,IPEKCI Hazal,USTUNDAG Unsal Veli,AKBAY Tugba Tunalı,ALTURFAN Ebru EMEKLI,SENER Goksel,YARAT Aysen Brain in metabolic syndrome model: The effect of exercises and caloric restriction. Journal of research in pharmacy (online), vol.26, no.5, 2022, ss.1352 - 1362. 10.29228/jrp.227
AMA ALEV-TUZUNER B,GENC-KAHRAMAN N,IPEKCI H,USTUNDAG U,AKBAY T,ALTURFAN E,SENER G,YARAT A Brain in metabolic syndrome model: The effect of exercises and caloric restriction. Journal of research in pharmacy (online). 2022; 26(5): 1352 - 1362. 10.29228/jrp.227
Vancouver ALEV-TUZUNER B,GENC-KAHRAMAN N,IPEKCI H,USTUNDAG U,AKBAY T,ALTURFAN E,SENER G,YARAT A Brain in metabolic syndrome model: The effect of exercises and caloric restriction. Journal of research in pharmacy (online). 2022; 26(5): 1352 - 1362. 10.29228/jrp.227
IEEE ALEV-TUZUNER B,GENC-KAHRAMAN N,IPEKCI H,USTUNDAG U,AKBAY T,ALTURFAN E,SENER G,YARAT A "Brain in metabolic syndrome model: The effect of exercises and caloric restriction." Journal of research in pharmacy (online), 26, ss.1352 - 1362, 2022. 10.29228/jrp.227
ISNAD ALEV-TUZUNER, Burcin vd. "Brain in metabolic syndrome model: The effect of exercises and caloric restriction". Journal of research in pharmacy (online) 26/5 (2022), 1352-1362. https://doi.org/10.29228/jrp.227
Sayfa Oluşturulma Tarihi
24-04-2024 3:33

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