Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and Dgalactose- induced Alzheimer's disease in rats

Kübra YALMAN, (Yeditepe Üniversitesi, Eczacılık Fakültesi, Farmakoloji Anabilim Dalı, İstanbul, Türkiye)
Ali ŞEN, (Marmara Üniversitesi Eczacılık Fakültesi Farmakognozi Anabilim Dalı, İstanbul, Türkiye)
Özge ÇEVIK, (Aydın Adnan Menderes Üniversitesi Tıp Fakültesi Biyokimya Anabilim Dalı, Aydın, Türkiye)
Beril KADIOĞLU YAMAN, (Yeditepe Üniversitesi, Eczacılık Fakültesi, Farmakoloji Anabilim Dalı, İstanbul, Türkiye)
Büşra ERTAŞ, (Marmara Üniversitesi Eczacılık Fakültesi Farmakoloji Anabilim Dalı, İstanbul, Türkiye)
Sıla YILDIZ, (Marmara Üniversitesi Eczacılık Fakültesi Farmakoloji Anabilim Dalı, İstanbul, Türkiye)
Göksel ŞENER (Fenerbahçe Üniversitesi, Eczacılık Fakültesi, Farmakoloji Anabilim Dalı, İstanbul, Türkiye)
Journal of research in pharmacy (online)
21 0
Yıl: 2022 Cilt: 26 Sayı: 5 Sayfa Aralığı: 1363 - 1374 Metin Dili: İngilizce DOI: 10.29228/jrp.242 İndeks Tarihi: 29-09-2022

Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and Dgalactose- induced Alzheimer's disease in rats

Öz:
This study investigated the possible protective and therapeutic effects of Myrtus communis subsp. communis ethanol extract (MC) in aluminum chloride (AlCl3) and D-galactose (D-Gal) induced Alzheimer's disease in rats. MC was orally given to rats as a protective treatment for 90 days and, in other two groups starting from the 60th day MC (100-200 mg/kg) was administered, concomitantly with AlCl3 and D-Gal. Learning and memory functions were evaluated by the behavioral tests. Biological activities of MC treatment were examined in hippocampal tissues by ELISA tests. D-Gal and AlCl3-treated rats showed increased amyloid beta (Aβ) and 8-hydroxy-2-deoxyguanosine (8- OHdG) levels, acetylcholinesterase activity and decreased neprilysin, Na+-K+ATPase and SOD levels in parallel with a decrease in Novel Object Recognition Test, Morris Water Maze and Passive Avoidance Test scores. On the other hand, MC administration reversed the behavioral impairments and improved learning and memory. Moreover, MC treatment decreased Aβ and 8-OHdG levels and acetylcholinesterase activity and increased neprilysin levels, Na+-K+ATPase and SOD levels. Our results suggest that MC has beneficial effects on cognitive and neuronal functions through its anticholinesterase and antioxidant properties.
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APA YALMAN K, ŞEN A, ÇEVIK Ö, YAMAN B, ERTAS B, YILDIZ S, ŞENER G (2022). Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and Dgalactose- induced Alzheimer's disease in rats. , 1363 - 1374. 10.29228/jrp.242
Chicago YALMAN Kübra,ŞEN ALİ,ÇEVIK Özge,YAMAN Beril KADIOĞLU,ERTAS BÜSRA,YILDIZ Sıla,ŞENER Göksel Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and Dgalactose- induced Alzheimer's disease in rats. (2022): 1363 - 1374. 10.29228/jrp.242
MLA YALMAN Kübra,ŞEN ALİ,ÇEVIK Özge,YAMAN Beril KADIOĞLU,ERTAS BÜSRA,YILDIZ Sıla,ŞENER Göksel Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and Dgalactose- induced Alzheimer's disease in rats. , 2022, ss.1363 - 1374. 10.29228/jrp.242
AMA YALMAN K,ŞEN A,ÇEVIK Ö,YAMAN B,ERTAS B,YILDIZ S,ŞENER G Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and Dgalactose- induced Alzheimer's disease in rats. . 2022; 1363 - 1374. 10.29228/jrp.242
Vancouver YALMAN K,ŞEN A,ÇEVIK Ö,YAMAN B,ERTAS B,YILDIZ S,ŞENER G Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and Dgalactose- induced Alzheimer's disease in rats. . 2022; 1363 - 1374. 10.29228/jrp.242
IEEE YALMAN K,ŞEN A,ÇEVIK Ö,YAMAN B,ERTAS B,YILDIZ S,ŞENER G "Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and Dgalactose- induced Alzheimer's disease in rats." , ss.1363 - 1374, 2022. 10.29228/jrp.242
ISNAD YALMAN, Kübra vd. "Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and Dgalactose- induced Alzheimer's disease in rats". (2022), 1363-1374. https://doi.org/10.29228/jrp.242
APA YALMAN K, ŞEN A, ÇEVIK Ö, YAMAN B, ERTAS B, YILDIZ S, ŞENER G (2022). Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and Dgalactose- induced Alzheimer's disease in rats. Journal of research in pharmacy (online), 26(5), 1363 - 1374. 10.29228/jrp.242
Chicago YALMAN Kübra,ŞEN ALİ,ÇEVIK Özge,YAMAN Beril KADIOĞLU,ERTAS BÜSRA,YILDIZ Sıla,ŞENER Göksel Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and Dgalactose- induced Alzheimer's disease in rats. Journal of research in pharmacy (online) 26, no.5 (2022): 1363 - 1374. 10.29228/jrp.242
MLA YALMAN Kübra,ŞEN ALİ,ÇEVIK Özge,YAMAN Beril KADIOĞLU,ERTAS BÜSRA,YILDIZ Sıla,ŞENER Göksel Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and Dgalactose- induced Alzheimer's disease in rats. Journal of research in pharmacy (online), vol.26, no.5, 2022, ss.1363 - 1374. 10.29228/jrp.242
AMA YALMAN K,ŞEN A,ÇEVIK Ö,YAMAN B,ERTAS B,YILDIZ S,ŞENER G Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and Dgalactose- induced Alzheimer's disease in rats. Journal of research in pharmacy (online). 2022; 26(5): 1363 - 1374. 10.29228/jrp.242
Vancouver YALMAN K,ŞEN A,ÇEVIK Ö,YAMAN B,ERTAS B,YILDIZ S,ŞENER G Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and Dgalactose- induced Alzheimer's disease in rats. Journal of research in pharmacy (online). 2022; 26(5): 1363 - 1374. 10.29228/jrp.242
IEEE YALMAN K,ŞEN A,ÇEVIK Ö,YAMAN B,ERTAS B,YILDIZ S,ŞENER G "Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and Dgalactose- induced Alzheimer's disease in rats." Journal of research in pharmacy (online), 26, ss.1363 - 1374, 2022. 10.29228/jrp.242
ISNAD YALMAN, Kübra vd. "Investigation of the protective and therapeutic efficacy of Myrtus communis extract in aluminum chloride and Dgalactose- induced Alzheimer's disease in rats". Journal of research in pharmacy (online) 26/5 (2022), 1363-1374. https://doi.org/10.29228/jrp.242
Sayfa Oluşturulma Tarihi
24-04-2024 3:33

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