Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity

Fatih TOK, (Marmara Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, İstanbul, Türkiye)
Muhammed Oğuzhan DOĞAN, (Marmara Üniversitesi, Eczacılık Fakültesi, İstanbul, Türkiye)
Burçak GÜRBÜZ, (Marmara Üniversitesi, Eczacılık Fakültesi, Farmasötik Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye)
Bedia KOÇYİĞİT KAYMAKÇIOĞLU (Marmara Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, İstanbul, Türkiye)
Journal of research in pharmacy (online)
3 0
Yıl: 2022 Cilt: 26 Sayı: 5 Sayfa Aralığı: 1453 - 1460 Metin Dili: İngilizce DOI: 10.29228/jrp.238 İndeks Tarihi: 29-09-2022

Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity

Öz:
In this study, new nine pyrazoline derivatives were synthesized from chalcone derivatives. The antimicrobial activity of nine pyrazoline derivatives to four standard bacterial strains (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis) and four standard yeast strains (Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis) was investigated by the microdilution method for in accordance with the Clinical and Laboratory Standards Institute (CLSI) standard, and the Minimal Inhibitory Concentration (MIC) values of these derivatives were determined. Among these derivatives; compounds 7 and 8 against bacterial strains and compounds 2 and 3 against yeast strains exhibited good antimicrobial activity.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • [1] Mitcheltree MJ, Pisipati A, Syroegin EA, Silvestre KJ, Klepacki D, Mason JD, Terwilliger DW, Testolin G, Pote AR, Wu KJY, Ladley RP, Chatman K, Mankin AS, Polikanov YS, Myers AG. A synthetic antibiotic class overcoming bacterial multidrug resistance. Nature. 2021; 599: 507-512. [CrossRef]
  • [2] Yılancıoğlu K. Antimicrobial drug interactions: systematic evaluation of protein and nucleic acid synthesis inhibitors. Antibiotics. 2019; 8(3): 1-8. [CrossRef]
  • [3] Sroor FM, Othman AM, Tantawy MA, Mahrous KF, El-Naggar ME. Synthesis, antimicrobial, anti-cancer and in silico studies of new urea derivatives. Bioorg Chem. 2021; 112: 1-15. [CrossRef]
  • [4] Prestinaci F, Pezzotti P, Pantosti A. Antimicrobial resistance: a global multifaceted phenomenon. Pathog Glob Health. 2015; 109(7): 309–318. [CrossRef]
  • [5] Ahmad A, Husain A, Khan SA, Mujeeb M, Bhandari A. Synthesis, antimicrobial and antitubercular activities of some novel pyrazoline derivatives. J Saudi Chem Soc. 2016; 20(5): 577-584. [CrossRef]
  • [6] Siddiqui ZN, Musthafa TNM, Ahmad A, Khan AU. Thermal solvent-free synthesis of novel pyrazolyl chalcones and pyrazolines as potential antimicrobial agents. Bioorg Med Chem Lett. 2011; 21(10): 2860-2865. [CrossRef]
  • [7] Shaik AB, Yejella RP, Shaik S. Synthesis, Antimicrobial, and Computational Evaluation of Novel Isobutylchalcones as Antimicrobial Agents. Int J Med Chem. 2017; 2017: 1-14. [CrossRef]
  • [8] Tok F, Koçyiğit-Kaymakçıoğlu B, Sağlık BN, Levent S, Özkay Y, Kaplancıklı ZA. Synthesis and biological evaluation of new pyrazolone Schiff bases as monoamine oxidase and cholinesterase inhibitors. Bioorg Chem. 2019; 84: 41-50. [CrossRef]
  • [9] Kaplancıklı ZA, Özdemir A, Turan-Zitouni G, Altıntop MD, Can ÖD. New pyrazoline derivatives and their antidepressant activity. Eur J Med Chem. 2010; 45(9): 4383-4387. [CrossRef]
  • [10] Kaplancıklı ZA, Turan-Zitouni G, Özdemir A, Can ÖD, Chevallet P. Synthesis and antinociceptive activities of some pyrazoline derivatives. Eur J Med Chem. 2009; 44(6): 2606-2610. [CrossRef]
  • [11] Naim MJ, Alam O, Nawaz F, Alam MJ, Alam P. Current status of pyrazole and its biological activities. J Pharm Bioall Sci. 2016; 8(1): 2-17. [CrossRef]
  • [12] Sağlık BN, Kaya Çavuşoğlu B, Acar Çevik U, Osmaniye D, Levent S, Özkay Y, Kaplancıklı ZA. Novel 1,3,4-thiadiazole compounds as potential MAO-A inhibitors – design, synthesis, biological evaluation and molecular modelling. RSC Med Chem. 2020; 11: 1063-1074. [CrossRef]
  • [13] Tok F, Koçyiğit-Kaymakçıoğlu B. Design, synthesis and biological screening of novel 1,5-diphenyl-3-(4- (trifluoromethyl)phenyl)-2-pyrazoline derivatives. Acta Chim Slov. 2020; 67: 1139–1147. [CrossRef]
  • [14] Tok F, Baltaş N, Tatar G, Koçyiğit-Kaymakçıoğlu B. Synthesis, biological evaluation and in silico studies of new pyrazoline derivatives bearing benzo[d]thiazol-2(3h)-one moiety as potential urease ınhibitors. Chem Biodiversity. 2022; 19: 1-11. [CrossRef]
  • [15] Clinical and Laboratory Standards Institute (CLSI), Performance Standarts for Antimicrobial Susceptibility Testing. 30th Ed, January CLSI supplement M100 Wayne, PA: Clinical and Laboratory Standarts Institue; 2020.
  • [16] Clinical and Laboratory Standards Institute (CLSI), Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; 4th Informational Supplement, M27-S4. CLSI, Wayne PA, USA. 2012.
  • [17] Berkow EL, Lockhart SR, Ostrosky-Zeichner L. Antifungal susceptibility testing: current approaches. Clin Microbiol Rev. 2020; 33(3). e00069-19. [CrossRef]
APA TOK F, DOĞAN M, GÜRBÜZ B, KOÇYİĞİT KAYMAKÇIOĞLU B (2022). Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity. , 1453 - 1460. 10.29228/jrp.238
Chicago TOK FATİH,DOĞAN Muhammed Oğuzhan,GÜRBÜZ Burçak,KOÇYİĞİT KAYMAKÇIOĞLU Bedia Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity. (2022): 1453 - 1460. 10.29228/jrp.238
MLA TOK FATİH,DOĞAN Muhammed Oğuzhan,GÜRBÜZ Burçak,KOÇYİĞİT KAYMAKÇIOĞLU Bedia Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity. , 2022, ss.1453 - 1460. 10.29228/jrp.238
AMA TOK F,DOĞAN M,GÜRBÜZ B,KOÇYİĞİT KAYMAKÇIOĞLU B Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity. . 2022; 1453 - 1460. 10.29228/jrp.238
Vancouver TOK F,DOĞAN M,GÜRBÜZ B,KOÇYİĞİT KAYMAKÇIOĞLU B Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity. . 2022; 1453 - 1460. 10.29228/jrp.238
IEEE TOK F,DOĞAN M,GÜRBÜZ B,KOÇYİĞİT KAYMAKÇIOĞLU B "Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity." , ss.1453 - 1460, 2022. 10.29228/jrp.238
ISNAD TOK, FATİH vd. "Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity". (2022), 1453-1460. https://doi.org/10.29228/jrp.238
APA TOK F, DOĞAN M, GÜRBÜZ B, KOÇYİĞİT KAYMAKÇIOĞLU B (2022). Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity. Journal of research in pharmacy (online), 26(5), 1453 - 1460. 10.29228/jrp.238
Chicago TOK FATİH,DOĞAN Muhammed Oğuzhan,GÜRBÜZ Burçak,KOÇYİĞİT KAYMAKÇIOĞLU Bedia Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity. Journal of research in pharmacy (online) 26, no.5 (2022): 1453 - 1460. 10.29228/jrp.238
MLA TOK FATİH,DOĞAN Muhammed Oğuzhan,GÜRBÜZ Burçak,KOÇYİĞİT KAYMAKÇIOĞLU Bedia Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity. Journal of research in pharmacy (online), vol.26, no.5, 2022, ss.1453 - 1460. 10.29228/jrp.238
AMA TOK F,DOĞAN M,GÜRBÜZ B,KOÇYİĞİT KAYMAKÇIOĞLU B Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity. Journal of research in pharmacy (online). 2022; 26(5): 1453 - 1460. 10.29228/jrp.238
Vancouver TOK F,DOĞAN M,GÜRBÜZ B,KOÇYİĞİT KAYMAKÇIOĞLU B Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity. Journal of research in pharmacy (online). 2022; 26(5): 1453 - 1460. 10.29228/jrp.238
IEEE TOK F,DOĞAN M,GÜRBÜZ B,KOÇYİĞİT KAYMAKÇIOĞLU B "Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity." Journal of research in pharmacy (online), 26, ss.1453 - 1460, 2022. 10.29228/jrp.238
ISNAD TOK, FATİH vd. "Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity". Journal of research in pharmacy (online) 26/5 (2022), 1453-1460. https://doi.org/10.29228/jrp.238
Sayfa Oluşturulma Tarihi
24-04-2024 3:33

İLETİŞİM

TÜBİTAK ULAKBİM TR Dizin

Yüzüncüyıl, İşçi Blokları Mahallesi

Muhsin Yazıcıoğlu Caddesi No:51/C

06530 Çankaya / ANKARA +90 (312) 298 92 00

trdizin@tubitak.gov.tr

TÜBİTAK ULAKBİM Ulusal Akademik Ağ ve Bilgi Merkezi Cahit Arf Bilgi Merkezi © Tüm Hakları Saklıdır. Gizlilik Politikası Kullanım Şartları