Chemical constituent of Isochrysis galbana microalgae extract and its cytotoxic activities on leukemic cell lines
Yıl: 2022 Cilt: 52 Sayı: 1 Sayfa Aralığı: 64 - 68 Metin Dili: İngilizce DOI: 10.26650/IstanbulJPharm.2022.1057338 İndeks Tarihi: 30-09-2022
Chemical constituent of Isochrysis galbana microalgae extract and its cytotoxic activities on leukemic cell lines
Öz: Background and Aims: This study was aimed to investigate the anti-cancer effect of Isochrysis galbana microalgae extract. Methods: In the study, the chemical composition of Isochrysis galbana microalgae extract was analyzed, and its cytotoxic effect against K562, HL60, U937, MOLT-4, and Raji cancer cells was investigated. ECV304 endothelial cells were used as a healthy cell line for the understanding of its selective cytotoxicity. To determine the effects of Isochrysis galbana extract, an MTT cytotoxicity assay was performed. Results: According to the results of the experiments, the highest cytotoxic effect of Isochrysis galbana microalgae extract was shown at about 24.07±6.48% cytotoxicity against Raji cells. There were a large number of bioactive molecules in the ex- tract, and these molecules showed a specific response to Raji cells when considering the synergistic and antagonistic effects of these molecules on each other. Conclusion: According to the results of GC-MS analysis of Isochrysis galbana microalgae extract, the most intense molecules in the content were Dodecanoic acid, 3-hydroxy- (CAS) Beta-Hydroxy Dodecanoic Acid, and Propanoic acid, 2-methyl-, 1-(1,1-dimethylethyl)-2-methyl-1,3-isonide. The investigation of the effect of these molecules specifically against Raji cells is important to determine the possible anti-leukemic molecules and their combinations that show cytotoxicity against this cell line.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA | Atasever Arslan B, yılancıoğlu k, KUSOGLU S, Albayrak İ (2022). Chemical constituent of Isochrysis galbana microalgae extract and its cytotoxic activities on leukemic cell lines. , 64 - 68. 10.26650/IstanbulJPharm.2022.1057338 |
Chicago | Atasever Arslan Belkıs,yılancıoğlu kaan,KUSOGLU SEDA,Albayrak İrem Gülfem Chemical constituent of Isochrysis galbana microalgae extract and its cytotoxic activities on leukemic cell lines. (2022): 64 - 68. 10.26650/IstanbulJPharm.2022.1057338 |
MLA | Atasever Arslan Belkıs,yılancıoğlu kaan,KUSOGLU SEDA,Albayrak İrem Gülfem Chemical constituent of Isochrysis galbana microalgae extract and its cytotoxic activities on leukemic cell lines. , 2022, ss.64 - 68. 10.26650/IstanbulJPharm.2022.1057338 |
AMA | Atasever Arslan B,yılancıoğlu k,KUSOGLU S,Albayrak İ Chemical constituent of Isochrysis galbana microalgae extract and its cytotoxic activities on leukemic cell lines. . 2022; 64 - 68. 10.26650/IstanbulJPharm.2022.1057338 |
Vancouver | Atasever Arslan B,yılancıoğlu k,KUSOGLU S,Albayrak İ Chemical constituent of Isochrysis galbana microalgae extract and its cytotoxic activities on leukemic cell lines. . 2022; 64 - 68. 10.26650/IstanbulJPharm.2022.1057338 |
IEEE | Atasever Arslan B,yılancıoğlu k,KUSOGLU S,Albayrak İ "Chemical constituent of Isochrysis galbana microalgae extract and its cytotoxic activities on leukemic cell lines." , ss.64 - 68, 2022. 10.26650/IstanbulJPharm.2022.1057338 |
ISNAD | Atasever Arslan, Belkıs vd. "Chemical constituent of Isochrysis galbana microalgae extract and its cytotoxic activities on leukemic cell lines". (2022), 64-68. https://doi.org/10.26650/IstanbulJPharm.2022.1057338 |
APA | Atasever Arslan B, yılancıoğlu k, KUSOGLU S, Albayrak İ (2022). Chemical constituent of Isochrysis galbana microalgae extract and its cytotoxic activities on leukemic cell lines. Istanbul Journal of Pharmacy, 52(1), 64 - 68. 10.26650/IstanbulJPharm.2022.1057338 |
Chicago | Atasever Arslan Belkıs,yılancıoğlu kaan,KUSOGLU SEDA,Albayrak İrem Gülfem Chemical constituent of Isochrysis galbana microalgae extract and its cytotoxic activities on leukemic cell lines. Istanbul Journal of Pharmacy 52, no.1 (2022): 64 - 68. 10.26650/IstanbulJPharm.2022.1057338 |
MLA | Atasever Arslan Belkıs,yılancıoğlu kaan,KUSOGLU SEDA,Albayrak İrem Gülfem Chemical constituent of Isochrysis galbana microalgae extract and its cytotoxic activities on leukemic cell lines. Istanbul Journal of Pharmacy, vol.52, no.1, 2022, ss.64 - 68. 10.26650/IstanbulJPharm.2022.1057338 |
AMA | Atasever Arslan B,yılancıoğlu k,KUSOGLU S,Albayrak İ Chemical constituent of Isochrysis galbana microalgae extract and its cytotoxic activities on leukemic cell lines. Istanbul Journal of Pharmacy. 2022; 52(1): 64 - 68. 10.26650/IstanbulJPharm.2022.1057338 |
Vancouver | Atasever Arslan B,yılancıoğlu k,KUSOGLU S,Albayrak İ Chemical constituent of Isochrysis galbana microalgae extract and its cytotoxic activities on leukemic cell lines. Istanbul Journal of Pharmacy. 2022; 52(1): 64 - 68. 10.26650/IstanbulJPharm.2022.1057338 |
IEEE | Atasever Arslan B,yılancıoğlu k,KUSOGLU S,Albayrak İ "Chemical constituent of Isochrysis galbana microalgae extract and its cytotoxic activities on leukemic cell lines." Istanbul Journal of Pharmacy, 52, ss.64 - 68, 2022. 10.26650/IstanbulJPharm.2022.1057338 |
ISNAD | Atasever Arslan, Belkıs vd. "Chemical constituent of Isochrysis galbana microalgae extract and its cytotoxic activities on leukemic cell lines". Istanbul Journal of Pharmacy 52/1 (2022), 64-68. https://doi.org/10.26650/IstanbulJPharm.2022.1057338 |