TY  - JOUR
TI  - Real-Life Experience Regarding Clinical Characteristics and Treatment Outcome in Non-Cutaneous Peripheral T-Cell Lymphomas: A Multicenter Study of the Turkish Hematology Research and Education Group (ThREG)
AB  - Objective: Peripheral T-cell lymphomas (PTCLs) are an uncommon and quite heterogeneous group of disorders, representing only 10%-15% of all non-Hodgkin lymphomas. Although both molecular and clinical studies have increased in recent years, we still have little knowledge regarding real-life practice with PTCLs. In this study, we aimed to investigate the clinical characteristics and treatment outcomes of a large population-based cohort of patients presenting with systemic non-cutaneous PTCL. Materials and Methods: We conducted a multicenter retrospective analysis of 190 patients consecutively diagnosed and treated with non-cutaneous PTCLs between 2008 and 2016. Results: Considering all first-line treatment combinations, the overall response rate was 65.9% with 49.4% complete remission (n=81) and 16.5% partial response (n=27). The 5-year overall survival and event- free survival rates were significantly different between the transplant and non-transplant groups (p<0.01, and p=0.033, respectively). Conclusion: The retrospective analysis of a large volume of real-life data on the Turkish experience regarding non-cutaneous PTCL patients showed consistent results compared to other unselected PTCL cohorts with some minor differences in terms of survival and transplantation outcomes. The long-term outcome of patients who receive autologous hematopoietic cell transplantation as part of upfront consolidation or salvage therapy is favorable compared to patients who are unable to receive high-dose therapy.
AU  - Cetin, Guven
AU  - Demirkan, Fatih
AU  - Buyukasik, Yahya
AU  - YILDIRIM, Rahsan
AU  - Beyan, Cengiz
AU  - Doğu, Mehmet Hilmi
AU  - Yilmaz, Mehmet
AU  - tekgunduz, emre
AU  - Gunduz, Mehmet
AU  - vural, filiz
AU  - Sari, Ismail
AU  - Kayıkçı, Ömür
AU  - Mehtap, Özgür
AU  - Ozkan, Hasan Atilla
AU  - Eser, Bülent
AU  - Öztürk, Erman
AU  - AKPINAR, SEVAL
AU  - Kelkitli, Engin
AU  - Payzin, Bahriye
DO  - 10.4274/tjh.galenos.2022.2022.0052
PY  - 2022
JO  - Turkish Journal of Hematology
VL  - 39
IS  - 3
SN  - 1300-7777
SP  - 170
EP  - 177
DB  - TRDizin
UR  - http://search/yayin/detay/1127363
ER  -