Dynamic Thiol/Disulphide Homeostasis a Promising New Marker in the Diagnosis of Acute Appendicitis in Children: A Case Control Study of Acute Appendicitis and Abdominal Pain

Kocyigit, Abdurrahim; Guler, Eray Metin; mirapoglu, semih lutfi; izzettin, fikret vehbi; Bektay, Muhammed Yunus

doi:10.33808/clinexphealthsci.814301

Dynamic Thiol/Disulphide Homeostasis a Promising New Marker in the Diagnosis of Acute Appendicitis in Children: A Case Control Study of Acute Appendicitis and Abdominal Pain

Semih Lütfi MİHRAPOĞLU, (Sağlık Bilimleri Üniversitesi, Ümraniye Eğitim ve Araştırma Hastanesi, Çocuk Cerrahisi Anabilim Dalı, İstanbul, Türkiye)

Eray Metin GÜLER, (Sağlık Bilimleri Üniversitesi, Hamidiye Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, İstanbul, Türkiye)

Muhammed Yunus BEKTAY, (Bezmialem Vakıf Üniversitesi, Eczacılık Fakültesi, Klinik Eczacılık Anabilim Dalı, İstanbul, Türkiye)

Abdurrahim KOÇYİĞİT, (Bezmialem Vakıf Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, İstanbul, Türkiye)

Fikret İZZETTİN (Bezmialem Vakıf Üniversitesi, Eczacılık Fakültesi, Klinik Eczacılık Anabilim Dalı, İstanbul, Türkiye)

Clinical and Experimental Health Sciences

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Yıl: 2022 Cilt: 12 Sayı: 1 Sayfa Aralığı: 82 - 86 Metin Dili: İngilizce DOI: 10.33808/clinexphealthsci.814301 İndeks Tarihi: 03-10-2022

Dynamic Thiol/Disulphide Homeostasis a Promising New Marker in the Diagnosis of Acute Appendicitis in Children: A Case Control Study of Acute Appendicitis and Abdominal Pain

Öz:

Objectives: One of the most common emergency surgery in pediatric surgery is due to acute appendicitis (AA). The diagnosis of AA is usually made using with the clinical score using clinical signs, symptoms, and laboratory tests. But symptoms and signs are not always typical, and this situation put clinician in a compelling situation. The range of misdiagnosis of AA is between 28-57 % between 2-12 years old children. Thiol/ Disulphide homeostasis is an important indicator of oxidative stress and inflammation. This study is aimed to evaluate and compare the feasibility of thiol/disulphide levels in pediatric patients with AA and abdominal pain (AP). Methods: In this case-control study three different group established with 25 healthy participants (NCG), 25 patients with abdominal pain (PCG), and 25 with AA (AAG). Demographics, white blood cell count, neutrophil-lymphocyte counts, hemoglobin, platelet, mean platelet volume, C-reactive protein, total thiol (TT), native thiol, (NT) and disulphide (DS) levels measure through blood samples. Results: According to our result, the level of NT were significantly lower in AAG when compared with NCG and PCG (p<0.001). DS levels were significantly higher in AAG than in NCG (p<0.001). CRP levels were significantly higher in both PCG and AAG than those of NCG p<0.001). Conclusion: Thiol/disulphide homeostasis is a valuable method to examine acute appendicitis in the pediatric patients. Fluctuations of thiol/ disulphide homeostasis could be used as a marker in daily clinical practice for diagnosis of appendicitis.

Anahtar Kelime: Thiol/disulfide homeostasis appendicitis pediatric population pediatric

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	mirapoglu s, Guler E, Bektay M, Kocyigit A, izzettin f (2022). Dynamic Thiol/Disulphide Homeostasis a Promising New Marker in the Diagnosis of Acute Appendicitis in Children: A Case Control Study of Acute Appendicitis and Abdominal Pain. , 82 - 86. 10.33808/clinexphealthsci.814301
Chicago	mirapoglu semih lutfi,Guler Eray Metin,Bektay Muhammed Yunus,Kocyigit Abdurrahim,izzettin fikret vehbi Dynamic Thiol/Disulphide Homeostasis a Promising New Marker in the Diagnosis of Acute Appendicitis in Children: A Case Control Study of Acute Appendicitis and Abdominal Pain. (2022): 82 - 86. 10.33808/clinexphealthsci.814301
MLA	mirapoglu semih lutfi,Guler Eray Metin,Bektay Muhammed Yunus,Kocyigit Abdurrahim,izzettin fikret vehbi Dynamic Thiol/Disulphide Homeostasis a Promising New Marker in the Diagnosis of Acute Appendicitis in Children: A Case Control Study of Acute Appendicitis and Abdominal Pain. , 2022, ss.82 - 86. 10.33808/clinexphealthsci.814301
AMA	mirapoglu s,Guler E,Bektay M,Kocyigit A,izzettin f Dynamic Thiol/Disulphide Homeostasis a Promising New Marker in the Diagnosis of Acute Appendicitis in Children: A Case Control Study of Acute Appendicitis and Abdominal Pain. . 2022; 82 - 86. 10.33808/clinexphealthsci.814301
Vancouver	mirapoglu s,Guler E,Bektay M,Kocyigit A,izzettin f Dynamic Thiol/Disulphide Homeostasis a Promising New Marker in the Diagnosis of Acute Appendicitis in Children: A Case Control Study of Acute Appendicitis and Abdominal Pain. . 2022; 82 - 86. 10.33808/clinexphealthsci.814301
IEEE	mirapoglu s,Guler E,Bektay M,Kocyigit A,izzettin f "Dynamic Thiol/Disulphide Homeostasis a Promising New Marker in the Diagnosis of Acute Appendicitis in Children: A Case Control Study of Acute Appendicitis and Abdominal Pain." , ss.82 - 86, 2022. 10.33808/clinexphealthsci.814301
ISNAD	mirapoglu, semih lutfi vd. "Dynamic Thiol/Disulphide Homeostasis a Promising New Marker in the Diagnosis of Acute Appendicitis in Children: A Case Control Study of Acute Appendicitis and Abdominal Pain". (2022), 82-86. https://doi.org/10.33808/clinexphealthsci.814301

APA	mirapoglu s, Guler E, Bektay M, Kocyigit A, izzettin f (2022). Dynamic Thiol/Disulphide Homeostasis a Promising New Marker in the Diagnosis of Acute Appendicitis in Children: A Case Control Study of Acute Appendicitis and Abdominal Pain. Clinical and Experimental Health Sciences, 12(1), 82 - 86. 10.33808/clinexphealthsci.814301
Chicago	mirapoglu semih lutfi,Guler Eray Metin,Bektay Muhammed Yunus,Kocyigit Abdurrahim,izzettin fikret vehbi Dynamic Thiol/Disulphide Homeostasis a Promising New Marker in the Diagnosis of Acute Appendicitis in Children: A Case Control Study of Acute Appendicitis and Abdominal Pain. Clinical and Experimental Health Sciences 12, no.1 (2022): 82 - 86. 10.33808/clinexphealthsci.814301
MLA	mirapoglu semih lutfi,Guler Eray Metin,Bektay Muhammed Yunus,Kocyigit Abdurrahim,izzettin fikret vehbi Dynamic Thiol/Disulphide Homeostasis a Promising New Marker in the Diagnosis of Acute Appendicitis in Children: A Case Control Study of Acute Appendicitis and Abdominal Pain. Clinical and Experimental Health Sciences, vol.12, no.1, 2022, ss.82 - 86. 10.33808/clinexphealthsci.814301
AMA	mirapoglu s,Guler E,Bektay M,Kocyigit A,izzettin f Dynamic Thiol/Disulphide Homeostasis a Promising New Marker in the Diagnosis of Acute Appendicitis in Children: A Case Control Study of Acute Appendicitis and Abdominal Pain. Clinical and Experimental Health Sciences. 2022; 12(1): 82 - 86. 10.33808/clinexphealthsci.814301
Vancouver	mirapoglu s,Guler E,Bektay M,Kocyigit A,izzettin f Dynamic Thiol/Disulphide Homeostasis a Promising New Marker in the Diagnosis of Acute Appendicitis in Children: A Case Control Study of Acute Appendicitis and Abdominal Pain. Clinical and Experimental Health Sciences. 2022; 12(1): 82 - 86. 10.33808/clinexphealthsci.814301
IEEE	mirapoglu s,Guler E,Bektay M,Kocyigit A,izzettin f "Dynamic Thiol/Disulphide Homeostasis a Promising New Marker in the Diagnosis of Acute Appendicitis in Children: A Case Control Study of Acute Appendicitis and Abdominal Pain." Clinical and Experimental Health Sciences, 12, ss.82 - 86, 2022. 10.33808/clinexphealthsci.814301
ISNAD	mirapoglu, semih lutfi vd. "Dynamic Thiol/Disulphide Homeostasis a Promising New Marker in the Diagnosis of Acute Appendicitis in Children: A Case Control Study of Acute Appendicitis and Abdominal Pain". Clinical and Experimental Health Sciences 12/1 (2022), 82-86. https://doi.org/10.33808/clinexphealthsci.814301