The Possible Useful Effectiveness of Sinapic Acid Sepsis-Induced Secondary Organ Damage in Rats

Ayhan TANYELİ, (Atatürk Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Erzurum, Türkiye)
Fazile Nur EKİNCİ AKDEMİR, (Ağrı İbrahim Çeçen Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü, Ağrı, Türkiye)
Ersen ERASLAN, (Bozok Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Yozgat, Türkiye)
Mustafa Can GÜLER, (Atatürk Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Erzurum, Türkiye)
SAIME OZBEK SEBIN, (Atatürk Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Erzurum, Türkiye)
Selim ÇOMAKLI, (Atatürk Üniversitesi, Veteriner Fakültesi, Patoloji Anabilim Dalı, Erzurum, Türkiye)
İlhami GÜLÇİN (Atatürk Üniversitesi, Fen Fakültesi, Kimya Bölümü, Erzurum, Türkiye)
Clinical and Experimental Health Sciences
4 1
Yıl: 2022 Cilt: 12 Sayı: 1 Sayfa Aralığı: 134 - 140 Metin Dili: İngilizce DOI: 10.33808/clinexphealthsci.864015 İndeks Tarihi: 03-10-2022

The Possible Useful Effectiveness of Sinapic Acid Sepsis-Induced Secondary Organ Damage in Rats

Öz:
Objectives: In this study, we investigated the possible useful effectiveness of Sinapic acid on rat kidney and lung tissues in an experimental cecal ligation puncture (CLP) model. Methods: CLP model was created for the rats in the CLP group. 20 mg/kg of Sinapic acid was given in the CLP-Sinapic acid group. At the end of the experiment, lung and kidney tissues were collected and biochemical analyzes were evaluated. Results: For the lung and kidney tissue samples; antioxidant levels decreased, and oxidant levels increased in the CLP group. When the immunohistochemical parameters were evaluated, IL-1β, caspase-3, and TNF-α immunopositivity were severe levels in CLP group. But immunopositivity of these parameters have been observed as attenuated in CLP-Sinapic acid group compared to CLP group. Conclusion: The results of our study showed that Sinapic acid has useful effectiveness on the sepsis model caused by CLP in the lung and kidney tissues.
Anahtar Kelime: Cecal ligation puncture sinapic acid lung kidney rat

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • [1] Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA. Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis. Chest. 1992;101(6):1644- 1655.
  • [2] Newland A, Provan D, Myint S. Preventing severe infection after splenectomy. BMJ. 2005;331(7514):417-418.
  • [3] Liu MW, Su MX, Wang YH, Wei W, Qin LF, Liu X. Effect of melilotus extract on lung injury by upregulating the expression of cannabinoid CB2 receptors in septic rats. BMC Complement Altern Med. 2014;14:94.
  • [4] Ritter C, Andrades M, Frota Junior ML, Bonatto F, Pinho RA, Polydoro M. Oxidative parameters and mortality in sepsis induced by cecal ligation and perforation. Intensive Care Med. 2003;29(10):1782-1789.
  • [5] Bone RC. Gram-negative sepsis – Background, clinical-features, and intervention. Chest. 1991;100(3):802-808.
  • [6] Otero-Anton E, Gonzalez-Quintela A, Lopez-Soto A, Lopez-Ben S, Llovo J, Perez LF. Cecal ligation and puncture as a model of sepsis in the rat: Influence of the puncture size on mortality, bacteremia, endotoxemia and tumor necrosis factor alpha levels. Eur Surg Res. 2001;33(2):77-79.
  • [7] Gulcin I. Antioxidant and antiradical activities of L-carnitine. Life Sci. 2006;78(8):803-811.
  • [8] Gulcin I. Antioxidant properties of resveratrol: A structure- activity insight. Innov Food Sci Emerg. 2010;11(1):210-218.
  • [9] Abd El-Latif AA, Sayed AA, Soliman AM, Fahmy SR. Exploration of the therapeutic potential effect of Sepia officinalis in animal model of sepsis induced by cecal ligation and puncture. Injury. 2016;47(12):2709-2717.
  • [10] GulcinI.Antioxidantactivityofcaffeicacid(3,4-dihydroxycinnamic acid). Toxicology. 2006;217(2-3):213-220.
  • [11] Hoste E, Bagshaw S, Bellomo R, Cely C, Colman R, Cruz D. Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intens Care Med. 2015;41(8):1411- 1423.
  • [12] Zhai Y, Zhou X, Dai Q, Fan Y, Huang X. Hydrogen-rich saline ameliorates lung injury associated with cecal ligation and puncture-induced sepsis in rats. Exp Mol Pathol. 2015;98(2):268-276.
  • [13] Gulcin I. Antioxidant activity of food constituents: an overview. Arch Toxicol. 2012;86(3):345-391.
  • [14] Gulcin I. Antioxidants and antioxidant methods: an updated overview. Arch Toxicol. 2020;94(3):651-715.
  • [15] Ansari MA. Sinapic acid modulates Nrf2/HO-1 signaling pathway in cisplatin-induced nephrotoxicity in rats. Biomed Pharmacother. 2017;93:646-653.
  • [16] Ansari MA, Raish M, Ahmad A, Ahmad SF, Mudassar S, Mohsin K. Sinapic acid mitigates gentamicin-induced nephrotoxicity and associated oxidative/nitrosative stress, apoptosis, and inflammation in rats. Life Sci. 2016;165:1-8.
  • [17] Roy SJ, Stanely Mainzen Prince P. Protective effects of sinapic acid on lysosomal dysfunction in isoproterenol induced myocardial infarcted rats. Food Chem Toxicol. 2012;50(11):3984-3989.
  • [18] Yun KJ, Koh DJ, Kim SH, Park SJ, Ryu JH, Kim DG. Anti- inflammatory effects of sinapic acid through the suppression of inducible nitric oxide synthase, cyclooxygase-2, and proinflammatory cytokines expressions via nuclear factor- kappaB inactivation. J Agric Food Chem. 2008;56(21):10265- 10272.
  • [19] Silambarasan T, Manivannan J, Priya MK, Suganya N, Chatterjee S, Raja B. Sinapic acid protects heart against ischemia/ reperfusion injury and H9c2 cardiomyoblast cells against oxidative stress. Biochem Bioph Res Co. 2015;456(4):853-859.
  • [20] Fazile Nur Ekinci Akdemir, Ayhan Tanyeri, Mustafa Can Güler, Ersen Eraslan, Emsal Pınar Topdağı Yılmaz, Yunus Emre Topdağı. Brusatol Mitigates Ovarian Tissue Oxidatif Injury Induced by Ovarian Ischemia Reperfusion. Akdeniz Medical Journal. 2021;7(2):206.
  • [21] Altindag F, Ragbetli MC, Ozdek U, Koyun N, Ismael Alhalboosi JK, Elasan S. Combined treatment of sinapic acid and ellagic acid attenuates hyperglycemia in streptozotocin-induced diabetic rats. Food Chem Toxicol. 2021;156:112443.
  • [22] Raish M, Ahmad A, Ansari MA, Alkharfy KM, Ahad A, Al-Jenoobi FI. Effects of sinapic acid on hepatic cytochrome P450 3A2, 2C11, and intestinal P-glycoprotein on the pharmacokinetics of oral carbamazepine in rats: Potential food/herb-drug interaction. Epilepsy Res. 2019;153:14-18.
  • [23] Hilal Kızıltunç Özmen, Fazile Nur Ekinci Akdemir, Ayhan Tanyeli, Serkan Yıldırım, Yasin Bayır, Yılmaz Şahin, Gizem Eser, Ayşenur Kahramanlar. Thymol May be an Effective Agent in the Treatment of Liver and Kidney Damages Caused by Ionizing Radiation. Turkish Journal of Oncology. 2021;36(1):575-82.
  • [24] Ohkawa H, Ohishi N, Yagi K. Assay for Lipid Peroxides in Animal-Tissues by Thiobarbituric Acid Reaction. Anal Biochem. 1979;95(2):351-8.
  • [25] Sun Y, Oberley LW, Li Y. A Simple Method for Clinical Assay of Superoxide-Dismutase. Clin Chem. 1988;34(3):497-500.
  • [26] Bradley PP, Priebat DA, Christensen RD, Rothstein G. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol. 1982;78(3):206-9.
  • [27] Topdağı Ö, Tanyeli A, Ekinci Akdemir FN, Eraslan E, Güler MC. Barbaloin attenuates oxidative testicular injury induced by ischemia reperfusion via antioxidant effects. Turkish Journal of Science 2020;5(1):28-33.
  • [28] Topdağı Ö, Tanyeli A, Ekinci Akdemir FN, Güzel Erdoğan D, Güler MC, Eraslan E. The effects of higenamine on testicular damage injured by ischemia reperfusion: A biochemical study. Turkish Journal of Science 2019;4(2):92-99.
  • [29] Celik H, Kandemir FM, Caglayan C, Ozdemir S, Comakli S, Kucukler S. Neuroprotective effect of rutin against colistin- induced oxidative stress, inflammation and apoptosis in rat brain associated with the CREB/BDNF expressions. Mol Biol Rep. 2020;47(3):2023-2034.
  • [30] Ozdemir S, Kucukler S, Comakli S, Kandemir FM. The protective effect of Morin against ifosfamide-induced acute liver injury in rats associated with the inhibition of DNA damage and apoptosis. Drug Chem Toxicol. 2020; 22:1-10.
  • [31] Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001;29(7):1303-1310.
  • [32] Vincent JL, Abraham E. The last 100 years of sepsis. Am J Respir Crit Care Med. 2006;173(3):256-263.
  • [33] Almog Y. Statins, inflammation, and sepsis: hypothesis. Chest. 2003;124(2):740-743.
  • [34] Cohen J. The immunopathogenesis of sepsis. Nature. 2002;420(6917):885-891.
  • [35] Gao F, Linhartova L, Johnston AM, Thickett DR. Statins and sepsis. Br J Anaesth. 2008;100(3):288-298.
  • [36] Goode HF, Webster NR. Free-radicals and antioxidants in sepsis. Crit Care Med. 1993;21(11):1770-1776.
  • [37] Nguyen HB, Rivers EP, Abrahamian FM, Moran GJ, Abraham E, Trzeciak S. Severe sepsis and septic shock: review of the literature and emergency department management guidelines. Ann Emerg Med. 2006;48(1):28-54.
  • [38] Babayigit H, Kucuk C, Sozuer E, Yazici C, Kose K, Akgun H. Protective effect of beta-glucan on lung injury after cecal ligation and puncture in rats. Intensive Care Med. 2005;31(6):865-870.
  • [39] Lee HT, Xu H, Siegel CD, Krichevsky IE. Local anesthetics induce human renal cell apoptosis. Am J Nephrol. 2003;23(3):129-139.
  • [40] Bursal E, Gulcin I. Polyphenol contents and in vitro antioxidant activities of lyophilised aqueous extract of kiwifruit (Actinidia deliciosa). Food Res Int. 2011;44(5):1482-1489.
  • [41] Gulcin I. Antioxidant activity of eugenol: A structure- activity relationship study. J Med Food. 2011;14(9):975- 985.
  • [42] Ak T, Gulcin I. Antioxidant and radical scavenging properties of curcumin. Chem Biol Interact. 2008;174(1):27-37.
  • [43] Halliwell B, Gutteridge JM. Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol. 1990;186:1-85.
  • [44] Kacmaz A, Polat A, User Y, Tilki M, Ozkan S, Sener G. Octreotide improves reperfusion-induced oxidative injury in acute abdominal hypertension in rats. J Gastrointest Surg. 2004;8(1):113-119.
  • [45] Aksoy AN, Toker A, Celik M, Aksoy M, Halici Z, Aksoy H. The effect of progesterone on systemic inflammation and oxidative stress in the rat model of sepsis. Indian J Pharmacol. 2014;46(6):622-626.
  • [46] Taner G, Aydin S, Bacanli M, Sarigol Z, Sahin T, Basaran AA, et al. Modulating effects of pycnogenol(R) on oxidative stress and DNA damage induced by sepsis in rats. Phytother Res. 2014;28(11):1692-1700.
  • [47] Cohen M, Lippman M, Chabner B. Role of pineal gland in aetiology and treatment of breast cancer. Lancet. 1978;2(8094):814-816.
  • [48] Xie K, Fu W, Xing W, Li A, Chen H, Han H. Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis. Shock. 2012;38(6):656-663.
  • [49] Cheng B, Zhang Y, Wang A, Dong Y, Xie Z. Vitamin C Attenuates isoflurane-induced caspase-3 activation and cognitive impairment. Mol Neurobiol. 2015;52(3):1580-1589.
  • [50] Nakagawa A, Sullivan KD, Xue D. Caspase-activated phosphoinositide binding by CNT-1 promotes apoptosis by inhibiting the AKT pathway. Nat Struct Mol Biol. 2014;21(12):1082-1090.
  • [51] Cho SY, Choi JH. Biomarkers of sepsis. Infect Chemother. 2014;46(1):1-12.
  • [52] Qiu R, Yao W, Ji H, Yuan D, Gao X, Sha W. Dexmedetomidine restores septic renal function via promoting inflammation resolution in a rat sepsis model. Life Sci. 2018;204:1-8.
  • [53] Wang B, Jiang J, Yang J, Chen J, Zhu Z, Liu J. Pharmacologic studies on ET-26 hydrochloride in a rat model of lipopolysaccharide- induced sepsis. Eur J Pharm Sci. 2017;109:441-445.
  • [54] Ekinci Akdemir FN, Tanyeli A. The antioxidant effect of Ffaxin against acute organ damage in polymicrobial sepsis model induced by cecal ligation and puncture. Turkish Journal of Science 2019;4:22-29.
  • [55] Sato Y, Itagaki S, Kurokawa T, Ogura J, Kobayashi M, Hirano T. In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid. Int J Pharmaceut. 2011;403(1-2):136-138.
  • [56] Kim DH, Yoon BH, Jung WY, Kim JM, Park SJ, Park DH. Sinapic acid attenuates kainic acid-induced hippocampal neuronal damage in mice. Neuropharmacology 2010;59(1- 2):20-30.
  • [57] Pari L, Jalaludeen AM. Protective role of sinapic acid against arsenic – Induced toxicity in rats. Chem-Biol Interact. 2011;194(1):40-47.
APA tanyeli a, Ekinci Akdemir F, Eraslan E, guler m, OZBEK SEBIN S, ÇOMAKLI S, Gulcin i (2022). The Possible Useful Effectiveness of Sinapic Acid Sepsis-Induced Secondary Organ Damage in Rats. , 134 - 140. 10.33808/clinexphealthsci.864015
Chicago tanyeli ayhan,Ekinci Akdemir Fazile Nur,Eraslan Ersen,guler mustafa can,OZBEK SEBIN SAIME,ÇOMAKLI Selim,Gulcin ilhami The Possible Useful Effectiveness of Sinapic Acid Sepsis-Induced Secondary Organ Damage in Rats. (2022): 134 - 140. 10.33808/clinexphealthsci.864015
MLA tanyeli ayhan,Ekinci Akdemir Fazile Nur,Eraslan Ersen,guler mustafa can,OZBEK SEBIN SAIME,ÇOMAKLI Selim,Gulcin ilhami The Possible Useful Effectiveness of Sinapic Acid Sepsis-Induced Secondary Organ Damage in Rats. , 2022, ss.134 - 140. 10.33808/clinexphealthsci.864015
AMA tanyeli a,Ekinci Akdemir F,Eraslan E,guler m,OZBEK SEBIN S,ÇOMAKLI S,Gulcin i The Possible Useful Effectiveness of Sinapic Acid Sepsis-Induced Secondary Organ Damage in Rats. . 2022; 134 - 140. 10.33808/clinexphealthsci.864015
Vancouver tanyeli a,Ekinci Akdemir F,Eraslan E,guler m,OZBEK SEBIN S,ÇOMAKLI S,Gulcin i The Possible Useful Effectiveness of Sinapic Acid Sepsis-Induced Secondary Organ Damage in Rats. . 2022; 134 - 140. 10.33808/clinexphealthsci.864015
IEEE tanyeli a,Ekinci Akdemir F,Eraslan E,guler m,OZBEK SEBIN S,ÇOMAKLI S,Gulcin i "The Possible Useful Effectiveness of Sinapic Acid Sepsis-Induced Secondary Organ Damage in Rats." , ss.134 - 140, 2022. 10.33808/clinexphealthsci.864015
ISNAD tanyeli, ayhan vd. "The Possible Useful Effectiveness of Sinapic Acid Sepsis-Induced Secondary Organ Damage in Rats". (2022), 134-140. https://doi.org/10.33808/clinexphealthsci.864015
APA tanyeli a, Ekinci Akdemir F, Eraslan E, guler m, OZBEK SEBIN S, ÇOMAKLI S, Gulcin i (2022). The Possible Useful Effectiveness of Sinapic Acid Sepsis-Induced Secondary Organ Damage in Rats. Clinical and Experimental Health Sciences, 12(1), 134 - 140. 10.33808/clinexphealthsci.864015
Chicago tanyeli ayhan,Ekinci Akdemir Fazile Nur,Eraslan Ersen,guler mustafa can,OZBEK SEBIN SAIME,ÇOMAKLI Selim,Gulcin ilhami The Possible Useful Effectiveness of Sinapic Acid Sepsis-Induced Secondary Organ Damage in Rats. Clinical and Experimental Health Sciences 12, no.1 (2022): 134 - 140. 10.33808/clinexphealthsci.864015
MLA tanyeli ayhan,Ekinci Akdemir Fazile Nur,Eraslan Ersen,guler mustafa can,OZBEK SEBIN SAIME,ÇOMAKLI Selim,Gulcin ilhami The Possible Useful Effectiveness of Sinapic Acid Sepsis-Induced Secondary Organ Damage in Rats. Clinical and Experimental Health Sciences, vol.12, no.1, 2022, ss.134 - 140. 10.33808/clinexphealthsci.864015
AMA tanyeli a,Ekinci Akdemir F,Eraslan E,guler m,OZBEK SEBIN S,ÇOMAKLI S,Gulcin i The Possible Useful Effectiveness of Sinapic Acid Sepsis-Induced Secondary Organ Damage in Rats. Clinical and Experimental Health Sciences. 2022; 12(1): 134 - 140. 10.33808/clinexphealthsci.864015
Vancouver tanyeli a,Ekinci Akdemir F,Eraslan E,guler m,OZBEK SEBIN S,ÇOMAKLI S,Gulcin i The Possible Useful Effectiveness of Sinapic Acid Sepsis-Induced Secondary Organ Damage in Rats. Clinical and Experimental Health Sciences. 2022; 12(1): 134 - 140. 10.33808/clinexphealthsci.864015
IEEE tanyeli a,Ekinci Akdemir F,Eraslan E,guler m,OZBEK SEBIN S,ÇOMAKLI S,Gulcin i "The Possible Useful Effectiveness of Sinapic Acid Sepsis-Induced Secondary Organ Damage in Rats." Clinical and Experimental Health Sciences, 12, ss.134 - 140, 2022. 10.33808/clinexphealthsci.864015
ISNAD tanyeli, ayhan vd. "The Possible Useful Effectiveness of Sinapic Acid Sepsis-Induced Secondary Organ Damage in Rats". Clinical and Experimental Health Sciences 12/1 (2022), 134-140. https://doi.org/10.33808/clinexphealthsci.864015
Sayfa Oluşturulma Tarihi
24-04-2024 14:33

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