TY  - JOUR
TI  - The Possible Useful Effectiveness of Sinapic Acid Sepsis-Induced Secondary Organ Damage in Rats
AB  - Objectives: In this study, we investigated the possible useful effectiveness of Sinapic acid on rat kidney and lung tissues in an experimental cecal ligation puncture (CLP) model. Methods: CLP model was created for the rats in the CLP group. 20 mg/kg of Sinapic acid was given in the CLP-Sinapic acid group. At the end of the experiment, lung and kidney tissues were collected and biochemical analyzes were evaluated. Results: For the lung and kidney tissue samples; antioxidant levels decreased, and oxidant levels increased in the CLP group. When the immunohistochemical parameters were evaluated, IL-1β, caspase-3, and TNF-α immunopositivity were severe levels in CLP group. But immunopositivity of these parameters have been observed as attenuated in CLP-Sinapic acid group compared to CLP group. Conclusion: The results of our study showed that Sinapic acid has useful effectiveness on the sepsis model caused by CLP in the lung and kidney tissues.
AU  - Ekinci Akdemir, Fazile Nur
AU  - Gulcin, ilhami
AU  - guler, mustafa can
AU  - tanyeli, ayhan
AU  - OZBEK SEBIN, SAIME
AU  - Eraslan, Ersen
AU  - ÇOMAKLI, Selim
DO  - 10.33808/clinexphealthsci.864015
PY  - 2022
JO  - Clinical and Experimental Health Sciences
VL  - 12
IS  - 1
SN  - 2459-1459
SP  - 134
EP  - 140
DB  - TRDizin
UR  - http://search/yayin/detay/1127964
ER  -