TY  - JOUR
TI  - Evaluation of Potential Inflammatory Markers for Cystic Echinococcosis: P-selectin and Resistin
AB  - Objective: Cystic echinococcosis (CE) is one of the most common zoonotic diseases  worldwide. Diagnosis of CE is predominantly based on imaging techniques and serological tests are used in cases of non-characteristic imaging findings as diagnostic reference.  However, serological test results cannot be completely reliable as they are affected by multi-factors.  P-selectin and resistin are inflammatory markers that are altered during the acute stages of infection. In this purpose, inflammatory markers as P-selectin and resistin have been investigated for a potential diagnostic reference for CE diagnosis. Methods: A total of 60 patients who were diagnosed with CE and twenty-five healthy individuals were included in this study. Blood samples were obtained from all participants. Obtained sera were evaluated using the P-selectin and resistin ELISA kits for protein levels. Additionally, the relative expression of SELP (P-selectin) and RETN (resistin) genes were determined using the comparative CT (∆∆CT) method between groups as CE patients with active and inactive cysts, CE patients and healthy controls. Results: SELP (13.9-fold change, p<0.05) and RETN (8.1-fold change, p<0.05) were differentially expressed in CE patients compared in the control group. Whereas resistin protein levels were significantly higher in CE patients than the healthy controls (p<0.001), the difference in P-selectin protein levels was not significant (p>0.05). There was no difference between active and inactive CE patients in terms of P-selectin and resistin in gene and protein levels (p>0.05). Conclusion: Although there was no difference between the active and inactive CE patients, the good differentiation between the healthy controls and the CE patients suggested that resistin is a potential inflammatory diagnostic reference
AU  - Baysal, ipek
AU  - Yabanoglu-ciftci, samiye
AU  - ÜNAL, Emre
AU  - AKINCI, Devrim
AU  - Akhan, Okan
AU  - Akyön Yilmaz, Yakut
AU  - Örsten, Serra
AU  - ÇİFTÇİ, Türkmen
AU  - Doğrul, Ahmet Bülent
DO  - 10.4274/tpd.galenos.2022.55265
PY  - 2022
JO  - Türkiye Parazitoloji Dergisi
VL  - 46
IS  - 3
SN  - 1300-6320
SP  - 195
EP  - 200
DB  - TRDizin
UR  - http://search/yayin/detay/1128228
ER  -