Biological and physical treatment in wastewater treatment plants appears to be one of the most important variables in water quality management and planning. This crucial characteristic, on the other hand, is difficult to quantify and takes a long time to obtain precise results. Scientists have sought to devise several solutions to address these issues. Artificial intelligence models are one technique to monitor the pollutant parameters more consistently and economically at treatment plants and regulate these pollution elements during processing. This study proposes using an adaptive network-based fuzzy inference system (ANFIS) model to regulate primary and biological wastewater treatment and used it to model the nonlinear interactions between influent pollutant factors and effluent variables in a wastewater treatment facility. Models for the prediction of removal efficiency of biological oxygen demand (BOD), total nitrogen (TN), total phosphorus (TP), and total suspended solids (TSS) in a wastewater treatment plant were developed using ANFIS. Hydraulic retention time (HRT), temperature (T), and dissolved oxygen (DO) were input variables for BOD, TN, TP, and TSS models, as determined by linear correlation matrices between input and output variables. The findings reveal that the developed system is capable of accurately predicting and controlling outcomes. For BOD, TN, TP, and TSS, ANFIS was able to achieve minimum mean square errors of 0.1673, 0.0266, 0.0318, and 0.0523, respectively. The correlation coefficients for BOD, TN, TP, and TSS are all quite strong. In the wastewater treatment plant, ANFIS' prediction performance was satisfactory and the ANFIS model can be used to predict the efficiency of removing pollutants from wastewater.