Effects of Acupuncture on Cholesterol, Antioxidant and Oxidant Parameters in Obese Women: Clinical Trials

Geçioğlu, Ersel; güçel, funda; mit, setenay; ÇEVIK, CEMAL; Çaycı, Banu; YILMAZ, CANAN; SEVERCAN, Cinar

doi:10.5336/jtracom.2021-87383

Effects of Acupuncture on Cholesterol, Antioxidant and Oxidant Parameters in Obese Women: Clinical Trials

setenay mit, (Gazi Üniversitesi Tıp Fakültesi, Akupunktur ve Tamamlayıcı Tıp Merkezi, Ankara, Türkiye)

Çınar SEVERCAN, (Zonguldak Bülent Ecevit Üniversitesi Eczacılık Fakültesi, Biyokimya Anabilim Dalı, Zonguldak, Türkiye)

Ersel GEÇİOĞLU, (Gazi Üniversitesi Tıp Fakültesi, Akupunktur ve Tamamlayıcı Tıp Merkezi, Ankara, Türkiye)

Banu Çaycı, (Gazi Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Ankara, Türkiye)

Canan YILMAZ, (Gazi Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Ankara, Türkiye)

Funda GÜÇEL, (Gazi Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Ankara, Türkiye)

CEMAL ÇEVIK (Lokman Hekim Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Ankara, Türkiye)

Geleneksel ve Tamamlayıcı Tıp Dergisi

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Yıl: 2022 Cilt: 5 Sayı: 2 Sayfa Aralığı: 96 - 105 Metin Dili: İngilizce DOI: 10.5336/jtracom.2021-87383 İndeks Tarihi: 05-10-2022

Effects of Acupuncture on Cholesterol, Antioxidant and Oxidant Parameters in Obese Women: Clinical Trials

Öz:

Objective: Obesity has a profound adverse impact on health care systems. Acupuncture has been shown to have beneficial effects on obesity. The aim of this study is to investigate the effects of acupuncture on serum oxidative stress parameters in obese women. Material and Methods: During the study, 20 obese patients had acupuncture treatment, and as a control group, 20 obese patients had sham acupuncture treatment. Serum samples were taken from each patient before the first session and at the end of the 10th session and serum levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL) cholesterol and low-density lipoprotein (LDL) cholesterol, malondialdehyde (MDA), advanced oxidation protein products (AOPP), the serum activity of superoxide dismutase enzyme (SOD) and glutathione peroxidase enzyme (GPx) were measured. Results: Changes in the serum levels of TG, HDL, MDA, AOPP and activity of SOD after the treatment compared to before the treatment in both acupuncture and sham acupuncture treated groups were found insignificant (p>0.05). On the other hand, the TC and LDL levels were observed to decrease significantly in comparison to the before-treatment values in both the acupuncture and sham acupuncture groups (p<0.05). In addition to this, the GPx activity significantly increased only as a result of the acupuncture treatment (p<0.05). Conclusion: The results of our study indicated that acupuncture treatment may be effective in reducing cholesterol levels and increasing the activity of antioxidant enzymes.

Anahtar Kelime:

Akupunkturun, Obez Kadınlardaki Kolesterol, Antioksidan ve Oksidan Parametreler Üzerine Etkileri: Klinik Deneyler

Öz:

Amaç: Obezite, bireyin sağlığı üzerinde olumsuz etkiye sahiptir. Akupunktur tedavisinin obezite üzerinde olumlu etkileri olduğu gösterilmiştir. Bu çalışmanın amacı, obez kadınlarda akupunkturun serum oksidatif stres parametreleri üzerindeki etkilerini araştırmaktır. Gereç ve Yöntemler: Çalışma süresince 20 obez bireye akupunktur tedavisi, kontrol grubu olarak 20 obez bireye sham akupunktur tedavisi uygulanmıştır. Her hastadan ilk seans öncesi ve 10. seans sonunda serum örnekleri alınarak toplam kolesterol [total cholesterol (TC)], trigliseridler (TG), yüksek yoğunluklu lipoprotein [high-density lipoprotein (HDL)] kolesterol ve düşük yoğunluklu lipoprotein [low-density lipoprotein (LDL)] kolesterol serum seviyeleri alınmıştır. Alınan serum örnekleri üzerinden kolesterol, malondialdehit (MDA), ileri oksidasyon protein ürünleri [advanced oxidation protein products (AOPP)], süperoksit dismutaz enzimi (SOD) ve glutatyon peroksidaz enzimi (GPx) serum aktivitesi ölçülmüştür. Bulgular: Hem akupunktur hem de sham akupunktur uygulanan gruplarda tedavi öncesi ile karşılaştırıldığında, tedavi sonrası serum TG, HDL, MDA, AOPP ve SOD aktivitesindeki farkın anlamlılığı bulunamamıştır (p>0,05). Buna rağmen hem akupunktur hem de sham akupunktur gruplarında TC ve LDL düzeylerinin tedavi öncesi değerlere göre anlamlı derecede düştüğü gözlenmiştir (p<0,05). Ek olarak, GPx aktivitesi sadece akupunktur tedavisi sonucunda anlamlı olarak artmıştır (p<0,05). Sonuç: Çalışmamızın sonuçları, akupunktur tedavisinin kolesterol düzeylerini düşürmede ve antioksidan enzimlerin aktivitesini artırmada etkili olabileceğini göstermiştir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	mit s, SEVERCAN C, Geçioğlu E, Çaycı B, YILMAZ C, güçel f, ÇEVIK C (2022). Effects of Acupuncture on Cholesterol, Antioxidant and Oxidant Parameters in Obese Women: Clinical Trials. , 96 - 105. 10.5336/jtracom.2021-87383
Chicago	mit setenay,SEVERCAN Cinar,Geçioğlu Ersel,Çaycı Banu,YILMAZ CANAN,güçel funda,ÇEVIK CEMAL Effects of Acupuncture on Cholesterol, Antioxidant and Oxidant Parameters in Obese Women: Clinical Trials. (2022): 96 - 105. 10.5336/jtracom.2021-87383
MLA	mit setenay,SEVERCAN Cinar,Geçioğlu Ersel,Çaycı Banu,YILMAZ CANAN,güçel funda,ÇEVIK CEMAL Effects of Acupuncture on Cholesterol, Antioxidant and Oxidant Parameters in Obese Women: Clinical Trials. , 2022, ss.96 - 105. 10.5336/jtracom.2021-87383
AMA	mit s,SEVERCAN C,Geçioğlu E,Çaycı B,YILMAZ C,güçel f,ÇEVIK C Effects of Acupuncture on Cholesterol, Antioxidant and Oxidant Parameters in Obese Women: Clinical Trials. . 2022; 96 - 105. 10.5336/jtracom.2021-87383
Vancouver	mit s,SEVERCAN C,Geçioğlu E,Çaycı B,YILMAZ C,güçel f,ÇEVIK C Effects of Acupuncture on Cholesterol, Antioxidant and Oxidant Parameters in Obese Women: Clinical Trials. . 2022; 96 - 105. 10.5336/jtracom.2021-87383
IEEE	mit s,SEVERCAN C,Geçioğlu E,Çaycı B,YILMAZ C,güçel f,ÇEVIK C "Effects of Acupuncture on Cholesterol, Antioxidant and Oxidant Parameters in Obese Women: Clinical Trials." , ss.96 - 105, 2022. 10.5336/jtracom.2021-87383
ISNAD	mit, setenay vd. "Effects of Acupuncture on Cholesterol, Antioxidant and Oxidant Parameters in Obese Women: Clinical Trials". (2022), 96-105. https://doi.org/10.5336/jtracom.2021-87383

APA	mit s, SEVERCAN C, Geçioğlu E, Çaycı B, YILMAZ C, güçel f, ÇEVIK C (2022). Effects of Acupuncture on Cholesterol, Antioxidant and Oxidant Parameters in Obese Women: Clinical Trials. Geleneksel ve Tamamlayıcı Tıp Dergisi, 5(2), 96 - 105. 10.5336/jtracom.2021-87383
Chicago	mit setenay,SEVERCAN Cinar,Geçioğlu Ersel,Çaycı Banu,YILMAZ CANAN,güçel funda,ÇEVIK CEMAL Effects of Acupuncture on Cholesterol, Antioxidant and Oxidant Parameters in Obese Women: Clinical Trials. Geleneksel ve Tamamlayıcı Tıp Dergisi 5, no.2 (2022): 96 - 105. 10.5336/jtracom.2021-87383
MLA	mit setenay,SEVERCAN Cinar,Geçioğlu Ersel,Çaycı Banu,YILMAZ CANAN,güçel funda,ÇEVIK CEMAL Effects of Acupuncture on Cholesterol, Antioxidant and Oxidant Parameters in Obese Women: Clinical Trials. Geleneksel ve Tamamlayıcı Tıp Dergisi, vol.5, no.2, 2022, ss.96 - 105. 10.5336/jtracom.2021-87383
AMA	mit s,SEVERCAN C,Geçioğlu E,Çaycı B,YILMAZ C,güçel f,ÇEVIK C Effects of Acupuncture on Cholesterol, Antioxidant and Oxidant Parameters in Obese Women: Clinical Trials. Geleneksel ve Tamamlayıcı Tıp Dergisi. 2022; 5(2): 96 - 105. 10.5336/jtracom.2021-87383
Vancouver	mit s,SEVERCAN C,Geçioğlu E,Çaycı B,YILMAZ C,güçel f,ÇEVIK C Effects of Acupuncture on Cholesterol, Antioxidant and Oxidant Parameters in Obese Women: Clinical Trials. Geleneksel ve Tamamlayıcı Tıp Dergisi. 2022; 5(2): 96 - 105. 10.5336/jtracom.2021-87383
IEEE	mit s,SEVERCAN C,Geçioğlu E,Çaycı B,YILMAZ C,güçel f,ÇEVIK C "Effects of Acupuncture on Cholesterol, Antioxidant and Oxidant Parameters in Obese Women: Clinical Trials." Geleneksel ve Tamamlayıcı Tıp Dergisi, 5, ss.96 - 105, 2022. 10.5336/jtracom.2021-87383
ISNAD	mit, setenay vd. "Effects of Acupuncture on Cholesterol, Antioxidant and Oxidant Parameters in Obese Women: Clinical Trials". Geleneksel ve Tamamlayıcı Tıp Dergisi 5/2 (2022), 96-105. https://doi.org/10.5336/jtracom.2021-87383