Objective: Treatment of multidrug-resistant Gram-negative bacteria is a global public health problem. Klebsiella pneumoniae resistant to carbapenems is one of the most important pathogens in this group. In this study, it was aimed to compare the resistance status of carbapenem-resistant and susceptible K. pneumoniae isolates to various antibiotics and to guide the treatment. Methods: The resistance rates of 709 carbapenem-resistant and 3029 carbapenem-susceptible 3738 K. pneumoniae isolates isolated from various clinical specimens were retrospectively analysed and their resistance to various antibiotics were compared. Identification of isolated microorganisms and antibiotic susceptibility tests were performed with the VITEK 2 (bioMérieux, France) automated system, and the results were interpreted according to European Committee on Antimicrobial Susceptibility Testing (EUCAST) standards. Ceftazidime/ avibactam susceptibility was also studied by disc diffusion method in isolates resistant to carbapenems. Broth microdilution method was used to determine the sensitivity of colistin. Those who were moderately susceptible as a result of the antibiogram were accepted as susceptible and one isolate from each patient was included in the study. Results: In carbapenem-resistant K. pneumoniae isolates, amikacin, amoxicillin/ clavulanate, aztreonam, cefazolin, cefepime, cefixime, cefoxitin, ceftazidime, ceftriaxone, cefuroxime, ciprofloxacin, colistin, fosfomycin, gentamicin, levofloxacin, netilmicin, nitrofurantoin, piperacillin/ tazobactam, trimethoprim/ sulfamethoxazole resistance rates respectively; 53.12%, 99.78%, 98.33%, 100%, 98.26%, 97.90%, 98.68%, 98.57%, 98.35%, 98.77%, 94.63%, 16.74%, 41.36%, 59.32%, 92.53%, 79.9%, 67.02%, 99.45%, 72.23% and it was found to be significantly higher than K. pneumoniae isolates susceptible to carbapenems (p<0.001). Ceftazidime/ avibactam resistance was found in 22.5% of isolates resistant to carbapenems. Conclusion: It is observed that carbapenem-resistant K. pneumoniae isolates are more resistant to non- carbapenem antimicrobials than carbapenem- susceptible isolates. It is thought that colistin, which seems to be the most effective, can be kept as a last option due to its nephrotoxic effects, ceftazidime/ avibactam can be used in appropriate cases, aminoglycosides can be used in combination therapy and fosfomycin may be a suitable option in urinary tract infections.