Acupuncture Decreases Attack Frequency and Improves Disability in Patients with Migraine Without Aura: A Randomized Controlled Trial

BİLGE, NURAY; Cayir, Yasemin; Akıncı, Rabia Rukiye

doi:10.5505/amj.2022.41196

Acupuncture Decreases Attack Frequency and Improves Disability in Patients with Migraine Without Aura: A Randomized Controlled Trial

Rabia Rukiye AKINCI, (Kadınhanı Refik Saime Koyuncu Devlet Hastanesi, Aile Hekimliği Anabilim Dalı, Konya, Türkiye)

Yasemin ÇAYIR, (Atatürk Üniversitesi, Tıp Fakültesi, Aile Hekimliği Anabilim Dalı, Erzurum, Türkiye)

Nuray BİLGE (Atatürk Üniversitesi, Tıp Fakültesi, Nöroloji Anabilim Dalı, Erzurum, Türkiye)

Ankara Medical Journal

9 2

Yıl: 2022 Cilt: 22 Sayı: 3 Sayfa Aralığı: 370 - 380 Metin Dili: İngilizce DOI: 10.5505/amj.2022.41196 İndeks Tarihi: 05-10-2022

Acupuncture Decreases Attack Frequency and Improves Disability in Patients with Migraine Without Aura: A Randomized Controlled Trial

Öz:

Objectives: This study investigated the effect of acupuncture treatment on attack frequency, pain intensity, and disability in patients with migraine without aura that received prophylaxis treatment. Materials and Methods: Eighty-four patients with migraine without aura were randomized to the intervention group (IG; n=42) and control group (CG; n=42). IG received 12 sessions of Acupuncture in addition to prophylaxis treatment. CG received only prophylaxis treatment. The primary outcome measures were monthly attack frequency, duration of attacks and pain severity during attacks. The secondary outcome measure included a change of Migraine Disability Assessment (MIDAS) scores from baseline to endpoints. All participants were followed up for three months. Results: A total of 80 participants completed the study. There were no statistically significant differences between the IG and CG for either socio-demographic features or the outcome measures at baseline. VAS score decreased from 8.8±0.9 to 3.9±1.5 in IG, while it decreased from 8.7±0.8 to 4.4±2.4 in CG (p=0.001). After three months mean monthly attack frequency decreased from 7.2±3.0 to 3.3±2.3 in IG, while it decreased from 6.3±3.3 to 4.4±2.4 in CG (p=0.040). The mean duration of attacks was 12.1± 2.6 hours before intervention; it decreased to 3.1±1.7 hours in IG (p=0.002). There was a significantly higher proportion of participants in IG who had MIDAS Grade 2 compared to those with CG (42.50% versus 2.50%) at the end of the study (p=0.001). Conclusion: Acupuncture may be suggested as a complementary treatment option to optimize the clinical management of patients with migraine without aura via decreasing attack frequency and pain severity, also improving disability.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Burch RC, Buse DC, Lipton RB. Migraine: Epidemiology, Burden, and Comorbidity. Neurol Clin. 2019;37(4):631-49 (doi:10.1016/j.ncl.2019.06.001).
2. Group GBDNDC. Global, regional, and national burden of neurological disorders during 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Neurol. 2017;16(11):877-97 (doi:10.1016/S1474-4422(17)30299-5).
3. Buse DC, Rupnow MF, Lipton RB. Assessing and managing all aspects of migraine: migraine attacks, migraine-related functional impairment, common comorbidities, and quality of life. Mayo Clin Proc. 2009;84(5):422-35 (doi:10.1016/S0025-6196(11)60561-2).
4. Gilmore B, Michael M. Treatment of Acute Migraine Headache. Am Fam Physician. 2011;83(3):271-80.
5. Johnston MM, Rapoport AM. Triptans for the management of migraine. Drugs. 2010;70(12):1505-18 (doi:10.2165/11537990-000000000-00000).
6. Modi S, Lowder DM. Medications for migraine prophylaxis. Am Fam Physician. 2006;73(1):72-8.
7. D'Amico D, Tepper SJ. Prophylaxis of migraine: general principles and patient acceptance. Neuropsychiatr Dis Treat. 2008;4(6):1155-67 (doi:10.2147/ndt.s3497).
8. Ha H, Gonzalez A. Migraine Headache Prophylaxis. Am Fam Physician. 2019;99(1):17-24.
9. Cayir Y, Ozdemir G, Celik M, et al. Acupuncture decreases matrix metalloproteinase-2 activity in patients with migraine. Acupunct Med. 2014;32(5):376-80 (doi:10.1136/acupmed-2014-010612).
10. Molsberger A. The role of Acupuncture in the treatment of migraine. CMAJ. 2012;184(4):391-2 (doi:10.1503/cmaj.112032).
11. Linde K, Allais G, Brinkhaus B, Manheimer E, Vickers A, White AR. Acupuncture for migraine prophylaxis. Cochrane Database Syst Rev. 2009(1):CD001218 (doi:10.1002/14651858.CD001218.pub2).
12. Tfelt-Hansen P, Pascual J, Ramadan N, et al. Guidelines for controlled trials of drugs in migraine: third edition. A guide for investigators. Cephalalgia. 2012;32(1):6-38 (doi:10.1177/0333102411417901).
13. Lipton RB, Stewart WF, Sawyer J, Edmeads JG. Clinical utility of an instrument assessing migraine disability: the Migraine Disability Assessment (MIDAS) questionnaire. Headache. 2001;41(9):854-61.
14. Ertaş M, Siva A, Dalkara T, Uzuner N, Dora B, İnan L, et al. Validity and reliability of the Turkish Migraine Disability Assessment (MIDAS) questionnaire. Headache. 2004;44(8):786-93.
15. Wells RE, Bertisch SM, Buettner C, Phillips RS, McCarthy EP. Complementary and alternative medicine use among adults with migraines/severe headaches. Headache. 2011;51(7):1087-97 (doi:10.1111/j.1526-4610.2011.01917.x).
16. Zhao L, Chen J, Li Y, et al. The Long-term Effect of Acupuncture for Migraine Prophylaxis: A Randomized Clinical Trial. JAMA Intern Med. 2017;177(4):508-15 (doi:10.1001/jamainternmed.2016.9378).
17. Linde K, Allais G, Brinkhaus B, et al. Acupuncture for the prevention of episodic migraine. Cochrane Database Syst Rev. 2016(6):CD001218 (doi:10.1002/14651858.CD001218.pub3).
18. Li Y, Zheng H, Witt CM, et al. Acupuncture for migraine prophylaxis: a randomized controlled trial. CMAJ. 2012;184(4):401-10 (doi:10.1503/cmaj.110551).
19. Burke A, Upchurch DM, Dye C, Chyu L. Acupuncture use in the United States: findings from the National Health Interview Survey. J Altern Complement Med. 2006;12(7):639-48 (doi:10.1089/acm.2006.12.639).
20. Alecrim-Andrade J, Maciel-Junior JA, Carne X, Severino Vasconcelos GM, Correa-Filho HR. Acupuncture in migraine prevention: a randomized sham controlled study with 6-months posttreatment follow-up. Clin J Pain. 2008;24(2):98-105 (doi:10.1097/AJP.0b013e3181590d66).
21. Wang LP, Zhang XZ, Guo J, et al. Efficacy of Acupuncture for acute migraine attack: a multicenter single blinded, randomized controlled trial. Pain Med. 2012;13(5):623-30 (doi:10.1111/j.1526- 4637.2012.01376.x).
22. DALYs GBD, Collaborators H. Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990- 2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1859-922 (doi:10.1016/S0140-6736(18)32335-3).
23. Lombard L, Farrar M, Ye W, et al. A global real-world assessment of the impact on health-related quality of life and work productivity of migraine in patients with insufficient versus good response to triptan medication. J Headache Pain. 2020;21(1):41 (doi:10.1186/s10194-020-01110-9).
24. Brandes JL. The migraine cycle: patient burden of migraine during and between migraine attacks. Headache. 2008;48(3):430-41 (doi:10.1111/j.1526-4610.2007.01004.x).
25. Vijayalakshmi I, Shankar N, Saxena A, Bhatia MS. Comparison of effectiveness of acupuncture therapy and conventional drug therapy on psychological profile of migraine patients. Indian J Physiol Pharmacol. 2014;58(1):69-76.
26. Moffet HH. Sham Acupuncture may be as efficacious as true Acupuncture: a systematic review of clinical trials. J Altern Complement Med. 2009;15(3):213-6 (doi:10.1089/acm.2008.0356).

APA	Akıncı R, Cayir Y, BİLGE N (2022). Acupuncture Decreases Attack Frequency and Improves Disability in Patients with Migraine Without Aura: A Randomized Controlled Trial. , 370 - 380. 10.5505/amj.2022.41196
Chicago	Akıncı Rabia Rukiye,Cayir Yasemin,BİLGE NURAY Acupuncture Decreases Attack Frequency and Improves Disability in Patients with Migraine Without Aura: A Randomized Controlled Trial. (2022): 370 - 380. 10.5505/amj.2022.41196
MLA	Akıncı Rabia Rukiye,Cayir Yasemin,BİLGE NURAY Acupuncture Decreases Attack Frequency and Improves Disability in Patients with Migraine Without Aura: A Randomized Controlled Trial. , 2022, ss.370 - 380. 10.5505/amj.2022.41196
AMA	Akıncı R,Cayir Y,BİLGE N Acupuncture Decreases Attack Frequency and Improves Disability in Patients with Migraine Without Aura: A Randomized Controlled Trial. . 2022; 370 - 380. 10.5505/amj.2022.41196
Vancouver	Akıncı R,Cayir Y,BİLGE N Acupuncture Decreases Attack Frequency and Improves Disability in Patients with Migraine Without Aura: A Randomized Controlled Trial. . 2022; 370 - 380. 10.5505/amj.2022.41196
IEEE	Akıncı R,Cayir Y,BİLGE N "Acupuncture Decreases Attack Frequency and Improves Disability in Patients with Migraine Without Aura: A Randomized Controlled Trial." , ss.370 - 380, 2022. 10.5505/amj.2022.41196
ISNAD	Akıncı, Rabia Rukiye vd. "Acupuncture Decreases Attack Frequency and Improves Disability in Patients with Migraine Without Aura: A Randomized Controlled Trial". (2022), 370-380. https://doi.org/10.5505/amj.2022.41196

APA	Akıncı R, Cayir Y, BİLGE N (2022). Acupuncture Decreases Attack Frequency and Improves Disability in Patients with Migraine Without Aura: A Randomized Controlled Trial. Ankara Medical Journal, 22(3), 370 - 380. 10.5505/amj.2022.41196
Chicago	Akıncı Rabia Rukiye,Cayir Yasemin,BİLGE NURAY Acupuncture Decreases Attack Frequency and Improves Disability in Patients with Migraine Without Aura: A Randomized Controlled Trial. Ankara Medical Journal 22, no.3 (2022): 370 - 380. 10.5505/amj.2022.41196
MLA	Akıncı Rabia Rukiye,Cayir Yasemin,BİLGE NURAY Acupuncture Decreases Attack Frequency and Improves Disability in Patients with Migraine Without Aura: A Randomized Controlled Trial. Ankara Medical Journal, vol.22, no.3, 2022, ss.370 - 380. 10.5505/amj.2022.41196
AMA	Akıncı R,Cayir Y,BİLGE N Acupuncture Decreases Attack Frequency and Improves Disability in Patients with Migraine Without Aura: A Randomized Controlled Trial. Ankara Medical Journal. 2022; 22(3): 370 - 380. 10.5505/amj.2022.41196
Vancouver	Akıncı R,Cayir Y,BİLGE N Acupuncture Decreases Attack Frequency and Improves Disability in Patients with Migraine Without Aura: A Randomized Controlled Trial. Ankara Medical Journal. 2022; 22(3): 370 - 380. 10.5505/amj.2022.41196
IEEE	Akıncı R,Cayir Y,BİLGE N "Acupuncture Decreases Attack Frequency and Improves Disability in Patients with Migraine Without Aura: A Randomized Controlled Trial." Ankara Medical Journal, 22, ss.370 - 380, 2022. 10.5505/amj.2022.41196
ISNAD	Akıncı, Rabia Rukiye vd. "Acupuncture Decreases Attack Frequency and Improves Disability in Patients with Migraine Without Aura: A Randomized Controlled Trial". Ankara Medical Journal 22/3 (2022), 370-380. https://doi.org/10.5505/amj.2022.41196