Yıl: 2022 Cilt: 22 Sayı: 3 Sayfa Aralığı: 444 - 450 Metin Dili: İngilizce DOI: 10.5505/amj.2022.48344 İndeks Tarihi: 05-10-2022

Sjögren’s Syndrome: Is it Just Dryness?

Öz:
Objectives: Sjögren's syndrome (SS) is the most common autoimmune, multisystemic rheumatic disease. The wide spectrum of the signs and symptoms of SS often causes difficulties in diagnosis. Patients can apply with different complaints to general practitioners and many different specialists, apart from internists and ophthalmologists, who frequently encounter the disease. Our aim in this study was to evaluate the initial complaints of the patients who have been diagnosed with SS. Materials and Methods: Sixty-six patients who were diagnosed with primary SS according to 2012 or 2016 classification criteria were included in the study. The clinical and laboratory features were retrospectively evaluated. Results: The female/male ratio was 60/6. The initial complaint of most patients (n:34) was arthralgia or arthritis (51.51%). ANA was positive in 56 patients (84.84%), RF in 19 (28.78%), but not evaluated in 7 (10.6%), anti-SS-A in 29 (43.93%), and anti-SS-B in 16 (24.24%). Sixty-three patients had a positive Schirmer test. Minor salivary gland biopsy was obtained in 42 patients, and 28 had biopsy findings consistent with SS. Conclusion: SS is a common disease with a wide variety of clinical presentations. A detailed evaluation of patients is necessary to provide an accurate diagnosis and proper care.
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  • 1. Fox RI. Sjogren's Syndrome. Lancet 2005;366:321-31.
  • 2. Ramos-Casals M, Tzioufas AG, Font J. Primary Sjögren's syndrome: new clinical and therapeutic concepts. Ann Rheum Dis 2005;64:347.
  • 3. Kollert F, Fisher BA. Equal rights in autoimmunity: is Sjögren's syndrome ever 'secondary'? Rheumatology (Oxford) 2020;59:1218.
  • 4. Manthorpe R. Sjogren's syndrome criteria. Ann Rheum Dis 2002;61:482–4.
  • 5. Manthorpe R, Asmussen K, Oxholm P. Primary Sjogren's syndrome: diagnostic criteria, clinical features, and disease activity. J Rheumatol 1997;24, (Suppl 50):8–11.
  • 6. Manfrè V, Cafaro G, Riccucci I, et al. One year in review 2020: comorbidities, diagnosis and treatment of primary Sjögren's syndrome. Clin Exp Rheumatol. 2020;38 Suppl 126(4):10-22.
  • 7. Komori K, Komori M, Horino T, Nishiyama S, Takei M, Suganuma N. Factors associated with delayed diagnosis of Sjögren's syndrome among members of the Japanese Sjögren's Association for Patients. Clin Exp Rheumatol. 2021;39 Suppl 133(6):146-52.
  • 8. Shiboski CH, Shiboski SC, Seror R, et al. 2016 American College of Rheuma tology/European League Against Rheumatism classification criteria for primary Sjögren's syndrome: a consensus and datadriven methodology involving three international patient cohorts. Arthritis Rheumatol 2017;69:35–45.
  • 9. Shiboski SC, Shiboski CH, Criswell L, et al. Sjögren's International Collaborative Clinical Alliance (SICCA) Research Groups. American College of Rheumatology classification criteria for Sjögren's syndrome: a data-driven, expert consensus approach in the Sjögren's International Collaborative Clinical Alliance cohort. Arthritis Care Res (Hoboken). 2012;64(4):475-87.
  • 10. Ramos-Casals M, Brito-Zerón P, Kostov B, et al. Google-driven search for big data in autoimmune geoepidemiology: analysis of 394,827 patients with systemic autoimmune diseases. Autoimmun Rev. 2015 Aug;14(8):670-9.
  • 11. Brito-Zerón P, Baldini C, Bootsma H, et al. Sjögren syndrome. Nat Rev Dis Primers. 2016:7;2:16047.
  • 12. Ramos-Casals M, Brito-Zeron P, Solans R, et al. Systemic involvement in primary Sjögren's syndrome evaluated by the EULAR-SS disease activity index: analysis of 921 Spanish patients (GEAS-SS Registry). Rheumatology (Oxford) 2014; 53: 321–31.
  • 13. Baer AN. Diagnosis and classification of Sjögren's syndrome. In: Post TW, editor. UpToDate. Waltham (MA): UpToDate. [Internet] https://www.uptodate.com/contents/diagnosis-and-classification-of- sjogrens- syndrome?search=Diagnosis%20and%20classification%20of%20Sj%C3%B6gren%27s%20syndrome&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1 (Accessed 2022 Jun 24).
  • 14. Stefanski AL, Tomiak C, Pleyer U, Dietrich T, Burmester GR, Dörner T. The Diagnosis and Treatment of Sjögren's Syndrome. Dtsch Arztebl Int. 2017: 26;114(20):354-61.
  • 15. Baimpa E, Dahabreh IJ, Voulgarelis M, Moutsopoulos HM. Hematologic manifestations and predictors of lymphoma development in primary Sjögren syndrome: clinical and pathophysiologic aspects. Medicine (Baltimore) 2009; 88:284.
  • 16. Theander E, Henriksson G, Ljungberg O, et al. Lymphoma and other malignancies in primary Sjögren's syndrome: a cohort study on cancer incidence and lymphoma predictors. Ann Rheum Dis 2006; 65:796.
APA Şahin Tekin M, YILDIZ P, Yasar Bilge N (2022). Sjögren’s Syndrome: Is it Just Dryness?. , 444 - 450. 10.5505/amj.2022.48344
Chicago Şahin Tekin Melisa,YILDIZ PINAR,Yasar Bilge Nazife Sule Sjögren’s Syndrome: Is it Just Dryness?. (2022): 444 - 450. 10.5505/amj.2022.48344
MLA Şahin Tekin Melisa,YILDIZ PINAR,Yasar Bilge Nazife Sule Sjögren’s Syndrome: Is it Just Dryness?. , 2022, ss.444 - 450. 10.5505/amj.2022.48344
AMA Şahin Tekin M,YILDIZ P,Yasar Bilge N Sjögren’s Syndrome: Is it Just Dryness?. . 2022; 444 - 450. 10.5505/amj.2022.48344
Vancouver Şahin Tekin M,YILDIZ P,Yasar Bilge N Sjögren’s Syndrome: Is it Just Dryness?. . 2022; 444 - 450. 10.5505/amj.2022.48344
IEEE Şahin Tekin M,YILDIZ P,Yasar Bilge N "Sjögren’s Syndrome: Is it Just Dryness?." , ss.444 - 450, 2022. 10.5505/amj.2022.48344
ISNAD Şahin Tekin, Melisa vd. "Sjögren’s Syndrome: Is it Just Dryness?". (2022), 444-450. https://doi.org/10.5505/amj.2022.48344
APA Şahin Tekin M, YILDIZ P, Yasar Bilge N (2022). Sjögren’s Syndrome: Is it Just Dryness?. Ankara Medical Journal, 22(3), 444 - 450. 10.5505/amj.2022.48344
Chicago Şahin Tekin Melisa,YILDIZ PINAR,Yasar Bilge Nazife Sule Sjögren’s Syndrome: Is it Just Dryness?. Ankara Medical Journal 22, no.3 (2022): 444 - 450. 10.5505/amj.2022.48344
MLA Şahin Tekin Melisa,YILDIZ PINAR,Yasar Bilge Nazife Sule Sjögren’s Syndrome: Is it Just Dryness?. Ankara Medical Journal, vol.22, no.3, 2022, ss.444 - 450. 10.5505/amj.2022.48344
AMA Şahin Tekin M,YILDIZ P,Yasar Bilge N Sjögren’s Syndrome: Is it Just Dryness?. Ankara Medical Journal. 2022; 22(3): 444 - 450. 10.5505/amj.2022.48344
Vancouver Şahin Tekin M,YILDIZ P,Yasar Bilge N Sjögren’s Syndrome: Is it Just Dryness?. Ankara Medical Journal. 2022; 22(3): 444 - 450. 10.5505/amj.2022.48344
IEEE Şahin Tekin M,YILDIZ P,Yasar Bilge N "Sjögren’s Syndrome: Is it Just Dryness?." Ankara Medical Journal, 22, ss.444 - 450, 2022. 10.5505/amj.2022.48344
ISNAD Şahin Tekin, Melisa vd. "Sjögren’s Syndrome: Is it Just Dryness?". Ankara Medical Journal 22/3 (2022), 444-450. https://doi.org/10.5505/amj.2022.48344