Novel Fumarate Derivatives Synthesis and Investigation of Acetylcholinesterase Inhibitor Properties
Yıl: 2021 Cilt: 8 Sayı: 2 Sayfa Aralığı: 544 - 551 Metin Dili: İngilizce DOI: 10.31202/ecjse.819956 İndeks Tarihi: 05-10-2022
Novel Fumarate Derivatives Synthesis and Investigation of Acetylcholinesterase Inhibitor Properties
Öz: n this study, new fumarate compounds (I-IV) containing some natural phenols (eugenol, guaiacol, isoeugenol and vanillin) were synthesized and characterized. The single crystal X-ray diffraction technique was used to determine the crystal structures of all compounds. All compounds were evaluated as acetylcholinesterase (AChE) inhibitory, especially compound IV (IC50 = 5.25±0.51 μg/mL), can be identified as a promising anti- acetylcholinesterase agent due to its good inhibitory effect, when compared with donepezil hydrochloride (IC50 =16.02±0.66 μg/mL) as used standard acetylcholinesterase inhibitory agent.
Anahtar Kelime: Yeni Fumarat Türevlerinin Sentezi ve Asetilkolinesteraz Inhibitörü Etkilerinin Araştırılması
Öz: Bu çalışmada, bazı doğal fenolleri (öjenol, guayakol, izoöjenol ve vanilin) içeren yeni fumarat bileşikleri (I- IV) sentezlenmiş ve karakterize edilmiştir. Tüm bileşiklerin kristal yapılarını belirlemek için tek kristal X-Işını kırınım tekniği kullanıldı. Tüm bileşikler asetilkolinesteraz (AChE) inhibitörü olabilecekmiş gibi değerlendirildi, özellikle bileşik IV (IC50 = 5.25±0.51 μg/mL), donepezil hidroklorür (IC50 = 16.02±0.66 μg/mL) ile karşılaştırıldığında, iyi inhibe edici etkisinden dolayı umut verici anti-asetilkolinesteraz ajanı olarak tanımlanabilir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | KAYA KANTAR G (2021). Novel Fumarate Derivatives Synthesis and Investigation of Acetylcholinesterase Inhibitor Properties. , 544 - 551. 10.31202/ecjse.819956 |
| Chicago | KAYA KANTAR GÜNAY Novel Fumarate Derivatives Synthesis and Investigation of Acetylcholinesterase Inhibitor Properties. (2021): 544 - 551. 10.31202/ecjse.819956 |
| MLA | KAYA KANTAR GÜNAY Novel Fumarate Derivatives Synthesis and Investigation of Acetylcholinesterase Inhibitor Properties. , 2021, ss.544 - 551. 10.31202/ecjse.819956 |
| AMA | KAYA KANTAR G Novel Fumarate Derivatives Synthesis and Investigation of Acetylcholinesterase Inhibitor Properties. . 2021; 544 - 551. 10.31202/ecjse.819956 |
| Vancouver | KAYA KANTAR G Novel Fumarate Derivatives Synthesis and Investigation of Acetylcholinesterase Inhibitor Properties. . 2021; 544 - 551. 10.31202/ecjse.819956 |
| IEEE | KAYA KANTAR G "Novel Fumarate Derivatives Synthesis and Investigation of Acetylcholinesterase Inhibitor Properties." , ss.544 - 551, 2021. 10.31202/ecjse.819956 |
| ISNAD | KAYA KANTAR, GÜNAY. "Novel Fumarate Derivatives Synthesis and Investigation of Acetylcholinesterase Inhibitor Properties". (2021), 544-551. https://doi.org/10.31202/ecjse.819956 |
| APA | KAYA KANTAR G (2021). Novel Fumarate Derivatives Synthesis and Investigation of Acetylcholinesterase Inhibitor Properties. El-Cezerî Journal of Science and Engineering, 8(2), 544 - 551. 10.31202/ecjse.819956 |
| Chicago | KAYA KANTAR GÜNAY Novel Fumarate Derivatives Synthesis and Investigation of Acetylcholinesterase Inhibitor Properties. El-Cezerî Journal of Science and Engineering 8, no.2 (2021): 544 - 551. 10.31202/ecjse.819956 |
| MLA | KAYA KANTAR GÜNAY Novel Fumarate Derivatives Synthesis and Investigation of Acetylcholinesterase Inhibitor Properties. El-Cezerî Journal of Science and Engineering, vol.8, no.2, 2021, ss.544 - 551. 10.31202/ecjse.819956 |
| AMA | KAYA KANTAR G Novel Fumarate Derivatives Synthesis and Investigation of Acetylcholinesterase Inhibitor Properties. El-Cezerî Journal of Science and Engineering. 2021; 8(2): 544 - 551. 10.31202/ecjse.819956 |
| Vancouver | KAYA KANTAR G Novel Fumarate Derivatives Synthesis and Investigation of Acetylcholinesterase Inhibitor Properties. El-Cezerî Journal of Science and Engineering. 2021; 8(2): 544 - 551. 10.31202/ecjse.819956 |
| IEEE | KAYA KANTAR G "Novel Fumarate Derivatives Synthesis and Investigation of Acetylcholinesterase Inhibitor Properties." El-Cezerî Journal of Science and Engineering, 8, ss.544 - 551, 2021. 10.31202/ecjse.819956 |
| ISNAD | KAYA KANTAR, GÜNAY. "Novel Fumarate Derivatives Synthesis and Investigation of Acetylcholinesterase Inhibitor Properties". El-Cezerî Journal of Science and Engineering 8/2 (2021), 544-551. https://doi.org/10.31202/ecjse.819956 |
