TY  - JOUR
TI  - Novel Fumarate Derivatives Synthesis and Investigation of Acetylcholinesterase Inhibitor Properties
AB  - n this study, new fumarate compounds (I-IV) containing some natural phenols (eugenol, guaiacol, isoeugenol and vanillin) were synthesized and characterized. The single crystal X-ray diffraction technique was used to determine the crystal structures of all compounds. All compounds were evaluated as acetylcholinesterase (AChE) inhibitory, especially compound IV (IC50 = 5.25±0.51 μg/mL), can be identified as a promising anti- acetylcholinesterase agent due to its good inhibitory effect, when compared with donepezil hydrochloride (IC50 =16.02±0.66 μg/mL) as used standard acetylcholinesterase inhibitory agent.
AU  - KAYA KANTAR, GÜNAY
DO  - 10.31202/ecjse.819956
PY  - 2021
JO  - El-Cezerî Journal of Science and Engineering
VL  - 8
IS  - 2
SN  - 2148-3736
SP  - 544
EP  - 551
DB  - TRDizin
UR  - http://search/yayin/detay/1128844
ER  -