TY  - JOUR
TI  - In Silico Inhibition Potential of Artemisinin Derivatives Against SARS-CoV-2 Main Protease
AB  - The outbreak of COVID-19 caused by the SARS-CoV-2 virus has recently affected millions worldwide. The natural compounds obtained from medicinal plants have been proven to be the source of many treatments throughout history. Efforts to combat Sars-CoV-2 generally focused on repositioning drugs or finding treatments with natural compounds and have been rapidly ongoing. Main protease (Mpro) is a vital protein of SARS-CoV-2 and an important target of drug research. The present study evaluated seven artemisinin derivatives: artemisinin, artemether, arteether, artesunate, dihydroartemisinic acid, dihydroartemisinin and artemisinic acid. For this purpose, the molecular docking study was carried out to investigate the potency of artemisinin derivatives against the SARS-CoV-2 Mpro. As a result, artesunate, dihydroartemisinic acid and dihydroartemisinin had promising results in Mpro inhibition with the binding energies between -8.42 and -9.35 kcal/mol.
AU  - emirik, mustafa
DO  - 10.31202/ecjse.894617
PY  - 2021
JO  - El-Cezerî Journal of Science and Engineering
VL  - 8
IS  - 2
SN  - 2148-3736
SP  - 809
EP  - 816
DB  - TRDizin
UR  - http://search/yayin/detay/1129319
ER  -