TY  - JOUR
TI  - Investigation of CD40 -1C>T Genetic Variant and sCD40 Levels in Colorectal  Cancer
AB  - Introduction: Functional studies have shown that cancer cells inactivate CD40-CD40L costimulators, which contribute to immune escape by inhibiting CD40L expression. CD40 -1C>T (rs1883832) is a 5′ UTR variant and may cause changes in  protein level or function in the posttranslational process. In this article, we aimed to determine the importance of CD40 - 1C>T variant in terms of histopathological criteria and its effect on sCD40 levels in patients with CRC (colorectal cancer). Methods: In peripheral blood samples of ninety-three CRC and one hundred sixty-three controls, sCD40 level was detected by ELISA, and CD40-1C>T variant was detected by PCR-RFLP. Results: 1.48 times higher sCD40 level was found in CRC with CT compared to those with CC (p=0.007). The frequency of CT and TT genotypes was found to be higher in early tumor stage than in advanced tumor stage (p=0.041). It was observed that the frequency of CT genotype was higher in patients with distant organ metastases compared to those without. (p=0.02). Dsicussion and Conclusion: We do not think that the CD40-1C>T variant is an important part of CRC initiation. On the  other hand, our findings in favor of metastasis suggest that CD40 is a factor that may be effective in the progression stages.
AU  - arıkan, soykan
AU  - DEMİRKOL, ŞEYDA
AU  - Horozoğlu, Cem
AU  - HAKAN, Mehmet Tolgahan
AU  - KÜÇÜKHÜSEYİN, Özlem
AU  - SÖNMEZ, Dilara
AU  - KARADAĞ, Hazal
AU  - Yaylim, Ilhan
AU  - Yılmaz, Ümit
DO  - 10.5505/ktd.2022.62343
PY  - 2022
JO  - Kocaeli Tıp Dergisi
VL  - 11
IS  - 2
SN  - 2147-0758
SP  - 67
EP  - 73
DB  - TRDizin
UR  - http://search/yayin/detay/1130022
ER  -