TY  - JOUR
TI  - Effects of stem cells and amniotic fluid on uterus and ovaries in a rat model of abdominal adhesions: a controlled study
AB  - Objective: This study aimed to compare the effects of human umbilical cord mesenchymal stem cells (hUCMSCs), amniotic fluid (AF), and a combination of both on the uterus and ovaries in a rat model of abdominal adhesions. Material and Methods: This study was designed as a controlled study. Four groups, each consisting of six rats, were randomly formed. One group was designated as the control (CNT). hUCMSCs - applied (hUCSC), AF-applied (AMN), and a combination of both (hUCSC + AMN) were the experimental groups. All rats were given intraperitoneal talc powder to create adhesions. After 21 days, animals in experimental groups were further treated with hUCMSC, AF or a combination of these. Results: There was a statistically significant difference in primordial follicle count, endometrial gland number, and endometrial blood vessel count (p<0.05). AMN provided the best results in the endometrial vessel and primordial follicle count. The average endometrial gland count in AMN and hUCSC + AMN was similarly higher than CNT and hUCSC alone. Conclusion: There were significantly higher for counts for endometrial glands, endometrial blood vessels, and primordial follicles in the hUCSC, AMN and hUCSC + AMN groups compared to controls. Animals in the AMN group had the best result for endometrial vessel and highest primordial follicle count. (J Turk Ger Gynecol Assoc 2022; 23: 154-66)
AU  - Tümentemur, Gamze
AU  - Aygün, Elif Ganime
DO  - 10.4274/jtgga.galenos.2022.2022-1-14
PY  - 2022
JO  - Journal of the Turkish-German Gynecological Association
VL  - 23
IS  - 3
SN  - 1309-0399
SP  - 154
EP  - 166
DB  - TRDizin
UR  - http://search/yayin/detay/1130105
ER  -