TY  - JOUR
TI  - Prognostic Value of Tissue-Resident Memory T Cells and Tumor  Microenvironmental Features in Resected Pancreatic Adenocarcinoma
AB  - Background: Pancreatic ductal adenocarcinoma differs from other  solid tumors with its unique immunosuppressive microenvironment  and non-immunogenic feature. There are not many studies in the  literature investigating the effect of these features on prognosis. Aims: To investigate the prognostic value of tissue-resident memory  T cells, tumor microenvironment features, and tumor-associated  immune cells in resected pancreatic ductal adenocarcinomas. Study Design: Retrospective cross-sectional study. Methods: Of 138 patients diagnosed with pancreatic ductal  adenocarcinoma between 2011 and 2018, 81 were included in the  study. Specimens from operated patients were reassessed separately  as peritumoral and intratumoral areas for tissue resident memory  cells and tumor microenvironmental elements (tumor infiltrating  lymphocytes, tumor stroma, CD204+ macrophages, PDL1+ immune  cells). Disease-free survival and overall survival were defined from  the date of operation to the date of recurrence and the date of first  diagnosis to the date of death, respectively. If the patient was alive, the  last visit date was taken into account. Results: The median age at diagnosis was 63 (range: 40-78). The  median follow-up period was 18.9 months (range: 1.4-80.4 months).  Median overall survival was 23.7 months (1.4-80.4 months) and  median disease-free survival was 10.8 months (1.4-74.4 months). Patients with higher intra-tumoral tissue-resident memory cell  counts had a longer survival trend than those having lower values  (25.6 months vs. 18 months, respectively, P = .84). According to  microenvironmental evaluations, lower stromal score (defined as  stroma having less desmoplasia and rich in cells) and presence of  peritumoral Crohn’s-like inflammatory response were associated with  higher survival (29.2 months vs. 19.7 months for low vs. high stromal  scores, respectively, P = .16 and 30.2 months vs. 18.1 months for the  presence of Crohn’s-like inflammatory response P = .13). Decreased  survival was observed in tumors with increased CD204+ tumor associated macrophages which were immunosuppressive elements of  the microenvironment (12 months vs. 26.3 months for intra-tumoral  assessment, P = .29). Conclusion: Tissue-resident memory T cells and other  microenvironmental features may be prognostic in resectable pancreatic  ductal adenocarcinomas. Further studies with larger cohorts are needed  for validation.
AU  - Öztürk, Fatih emin
AU  - bagci, pelin
AU  - ARIKAN, RUKİYE
AU  - Dane, Faysal
AU  - Yumuk, Perran Fulden
AU  - Demircan, Nazım Can
AU  - Basoglu tuylu, Tugba
AU  - OZTURK, MEHMET AKIF
AU  - akgul babacan, nalan
AU  - Ercelep, Özlem
AU  - Akar, Kadriye Ebru
AU  - Akın Telli, Tugba
DO  - 10.5152/balkanmedj.2021.21122
PY  - 2022
JO  - Balkan Medical Journal
VL  - 39
IS  - 1
SN  - 2146-3123
SP  - 12
EP  - 20
DB  - TRDizin
UR  - http://search/yayin/detay/1130363
ER  -