Characteristics of the patients with asthma- rhinitis multimorbidity
Yıl: 2022 Cilt: 70 Sayı: 3 Sayfa Aralığı: 242 - 251 Metin Dili: İngilizce DOI: 10.5578/tt.20229703 İndeks Tarihi: 10-10-2022
Characteristics of the patients with asthma- rhinitis multimorbidity
Öz: Characteristics of the patients with asthma-rhinitis multimorbidity Introduction: Asthma and allergic rhinitis frequently coexist and have been regarded as a single airway disease. Clinical features of patients with asthma- rhinitis multimorbidity may change depending on the allergic sensitization pattern. The aim of our study is to determine the frequency, type, and charac- teristics of the patients with asthma-rhinitis multimorbidity. Materials and Methods: Patients who were followed up with a diagnosis of asthma between 2015 and 2020 in our clinic were included in our cross- sectional study. Sociodemographic and clinical characteristics of the patients, rhinitis symptoms, and atopy status according to the results of the skin prick test, and sp IgE were recorded from the patient files. Results: Asthma-rhinitis multimorbidity was seen in 138 (113 F/25 M) out of 405 asthmatics and the mean age was 45.51 ± 13.56 years. They were youn- ger and the age of onset of asthma was earlier than asthma patients without rhinitis. The rate of concomitant allergic rhinitis (AR) was 25.9%, and the rate of non-allergic rhinitis (NAR) was 8.1% in the entire group. There was no difference between patients with AR and NAR in terms of comorbidities such as NSAID sensitivity, nasal polyps, chronic rhinosinusitis, and bronchiectasis but, gastroesophageal reflux disease was more common in those with NAR than in those with AR (39.4%, 18.1%, respectively, p= 0.01). Of 105 asthma- tic patients accompanied by allergic rhinitis, 41 (39.09%) were monosensiti- zed, and 64 (60.95%) were polysensitized. House dust mites were found to be the most common responsible allergen in monosensitized patients. Sensitization to two allergens was the most common pattern among polysen- sitized patients, and mites and mold association was the most frequent. Patients with monosensitized allergic rhinitis had more severe asthma and a higher rate of NSAID sensitivity than polysensitized patients (p= 0.03, p= 0.04, respectively). There was no difference in the control level, frequency of eosinophilia, and other comorbidities. Conclusion: Our patients with asthma-rhinitis multimorbidity were mostly polysensitized. The most responsible allergen for the sensitization was house dust mites, regardless of whether the patient was monosensitized or polysen- sitized.
Anahtar Kelime: Characteristics of the patients with asthma- rhinitis multimorbidity
Öz: Astım-rinit multimorbiditeli hastaların özellikleri Giriş: Astım ve alerjik rinit birlikteliğinin sık olduğu bilinmektir ve artık tek hava yolu hastalığı kavramı benimsenmiştir. Bu iki hastalı- ğın birlikteliği astım kontrolünü ve yaşam kalitesini olumsuz etkilemektedir. Alerjik rinit hastalarının duyarlanma paternine göre hem astım ile birliktelikleri hem de klinik özellikleri değişebilmektedir. Çalışmamızın amacı, astımlı hastalarımızda rinit sıklığını, tipini ve özelliklerini belirlemekti. Materyal ve Metod: Kesitsel tipte olan çalışmamıza 2015-2020 yılları arasında astım tanısıyla takip ettiğimiz hastalar dahil edildi. Hasta dosyalarından, hastaların sosyodemografik ve klinik özellikleri, rinit semptomları ve atopi durumlarını değerlendiren deri prick testi ve sp IgE sonuçları kaydedildi. Bulgular: Kliniğimizde 2015-2020 yılları arasında astım tanısıyla izlediğimiz toplam 405 hastanın yaş ortalaması 45,51 ± 13,56 olan 138’inde (113 K/25 E) rinit eşlik ediyordu. Rinit eşlik eden astımlılar diğerlerinden daha gençti ve astım daha erken başlıyordu. Bu hastaların 105’i atopik, 33’ü nonatopikti. Dolayısıyla, astımlı hastalarımızda alerjik rinit (AR) eşlik etme oranı %25,9 iken, nonalerjik rinit (NAR) oranı %8,1 bulundu. Alerjik rinit ve NAR olan hastalar arasında NSAII duyarlılığı, nazal polip, kronik sinüzit, bronşektazi gibi komorbiditeler açısından fark yoktu; gastroözefageal reflü hastalığı NAR’lilerde AR’lilere göre daha sıktı (sırasıyla, %39,4, %18,1, p= 0,01). İki grup arasında eşlik eden astım fenotipi, kontrolü ve ağırlığı yönünden fark bulunmadı (p> 0,05). Alerjik rinitli hastaların NAR’lilerden daha genç olduğu görüldü. Alerjik rinitin astıma eşlik ettiği 105 astımlı hastanın 41’i (%39,09) monosensitize, 64’ü (%60,95) polisensitize idi. Monosensitize olan hastalarda ev tozu en sık sorumlu alerjen olarak bulunurken, polisensitize hastalar arasında sıklıkla iki alerjene duyarlanmanın olduğu ve ev tozu akarı ve küf mantarı birlikteliğinin en sık görüldüğü, çimen, ağaç ve tahıl polenlerinin ikili kombinasyonlarının bunu izlediği saptandı. Monosensitize alerjik rinitli hastalar polisensitize hastalara göre daha fazla ağır astıma sahipti (p= 0,03) ve NSAI duyarlılığı daha fazlaydı (p= 0,04). Monosensitize ve polisensitize hastalar arasında astım kontrol düzeyi, eozinofili ve komorbiditelerin sıklığı açısından fark saptanmadı (p> 0,05). Sonuç: Astım ve alerjik rinit birlikteliğinin olduğu hastalarımız çoğunlukla polisensitizeydi ve monosensitize ya da polisensitize olma- sı farketmeksizin duyarlanmadan en fazla sorumlu alerjen ev tozu olarak görülmektedir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | ÇELEBI SOZENER Z, Özdel Öztürk B, Demirel Y, Mungan D (2022). Characteristics of the patients with asthma- rhinitis multimorbidity. , 242 - 251. 10.5578/tt.20229703 |
| Chicago | ÇELEBI SOZENER ZEYNEP,Özdel Öztürk Betül,Demirel Yavuz Selim,Mungan Dilşad Characteristics of the patients with asthma- rhinitis multimorbidity. (2022): 242 - 251. 10.5578/tt.20229703 |
| MLA | ÇELEBI SOZENER ZEYNEP,Özdel Öztürk Betül,Demirel Yavuz Selim,Mungan Dilşad Characteristics of the patients with asthma- rhinitis multimorbidity. , 2022, ss.242 - 251. 10.5578/tt.20229703 |
| AMA | ÇELEBI SOZENER Z,Özdel Öztürk B,Demirel Y,Mungan D Characteristics of the patients with asthma- rhinitis multimorbidity. . 2022; 242 - 251. 10.5578/tt.20229703 |
| Vancouver | ÇELEBI SOZENER Z,Özdel Öztürk B,Demirel Y,Mungan D Characteristics of the patients with asthma- rhinitis multimorbidity. . 2022; 242 - 251. 10.5578/tt.20229703 |
| IEEE | ÇELEBI SOZENER Z,Özdel Öztürk B,Demirel Y,Mungan D "Characteristics of the patients with asthma- rhinitis multimorbidity." , ss.242 - 251, 2022. 10.5578/tt.20229703 |
| ISNAD | ÇELEBI SOZENER, ZEYNEP vd. "Characteristics of the patients with asthma- rhinitis multimorbidity". (2022), 242-251. https://doi.org/10.5578/tt.20229703 |
| APA | ÇELEBI SOZENER Z, Özdel Öztürk B, Demirel Y, Mungan D (2022). Characteristics of the patients with asthma- rhinitis multimorbidity. Tüberküloz ve Toraks, 70(3), 242 - 251. 10.5578/tt.20229703 |
| Chicago | ÇELEBI SOZENER ZEYNEP,Özdel Öztürk Betül,Demirel Yavuz Selim,Mungan Dilşad Characteristics of the patients with asthma- rhinitis multimorbidity. Tüberküloz ve Toraks 70, no.3 (2022): 242 - 251. 10.5578/tt.20229703 |
| MLA | ÇELEBI SOZENER ZEYNEP,Özdel Öztürk Betül,Demirel Yavuz Selim,Mungan Dilşad Characteristics of the patients with asthma- rhinitis multimorbidity. Tüberküloz ve Toraks, vol.70, no.3, 2022, ss.242 - 251. 10.5578/tt.20229703 |
| AMA | ÇELEBI SOZENER Z,Özdel Öztürk B,Demirel Y,Mungan D Characteristics of the patients with asthma- rhinitis multimorbidity. Tüberküloz ve Toraks. 2022; 70(3): 242 - 251. 10.5578/tt.20229703 |
| Vancouver | ÇELEBI SOZENER Z,Özdel Öztürk B,Demirel Y,Mungan D Characteristics of the patients with asthma- rhinitis multimorbidity. Tüberküloz ve Toraks. 2022; 70(3): 242 - 251. 10.5578/tt.20229703 |
| IEEE | ÇELEBI SOZENER Z,Özdel Öztürk B,Demirel Y,Mungan D "Characteristics of the patients with asthma- rhinitis multimorbidity." Tüberküloz ve Toraks, 70, ss.242 - 251, 2022. 10.5578/tt.20229703 |
| ISNAD | ÇELEBI SOZENER, ZEYNEP vd. "Characteristics of the patients with asthma- rhinitis multimorbidity". Tüberküloz ve Toraks 70/3 (2022), 242-251. https://doi.org/10.5578/tt.20229703 |
