Association analysis of two polymorphisms in neuregulin-1 gene in a Turkish schizophrenia sample

SÖZENA, Mustafa Mert; KARTALCI, ŞÜKRÜ; Saygılı, Ayşenur

doi:10.5455/annalsmedres.2022.03.104

Association analysis of two polymorphisms in neuregulin-1 gene in a Turkish schizophrenia sample

Aysenur Saygili, (İnönü Üniversitesi, Fen Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, Malatya, Türkiye)

Şükrü KARTALCI, (İnönü Üniversitesi, Fen Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, Malatya, Türkiye)

Mustafa Mert SÖZENA (İnönü Üniversitesi, Fen Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, Malatya, Türkiye)

Annals of Medical Research

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Yıl: 2022 Cilt: 29 Sayı: 9 Sayfa Aralığı: 1005 - 1008 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2022.03.104 İndeks Tarihi: 11-10-2022

Association analysis of two polymorphisms in neuregulin-1 gene in a Turkish schizophrenia sample

Öz:

Aim: NRG1 is one of the genes that was reported to have susceptibility alleles effecting the phenotype of schizophrenia. There are many SNPs (single nucleotide polymorphisms) located in the NRG1 gene with suspected alleles which were associated to schizophrenia. In this study, we investigated the potential associations between schizophrenia and NRG1 polymorphisms rs4560751 and rs3802160. Materials and Methods: We collected DNA samples of 96 patients diagnosed for schizophrenia and 100 healthy controls living in Malatya-Turkey. We genotyped two NRG1 SNPs mentioned above and compared case and control groups for distributions of alleles and genotypes. We also tested the potential associations in dominant models. We used Chi-Squared test for hypothesis testing. Results: No significant differences were seen between the groups of patients and controls for the distributions of alleles and genotypes of two NRG1 SNPs we have screened. Conclusion: The results of our experiments and statistical tests we have done indicated that in the population we have screened there was no sufficient evidence to support the association of NRG1 SNPs rs4560751 and rs3802160 with schizophrenia.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Saygılı A, KARTALCI Ş, SÖZENA M (2022). Association analysis of two polymorphisms in neuregulin-1 gene in a Turkish schizophrenia sample. , 1005 - 1008. 10.5455/annalsmedres.2022.03.104
Chicago	Saygılı Ayşenur,KARTALCI ŞÜKRÜ,SÖZENA Mustafa Mert Association analysis of two polymorphisms in neuregulin-1 gene in a Turkish schizophrenia sample. (2022): 1005 - 1008. 10.5455/annalsmedres.2022.03.104
MLA	Saygılı Ayşenur,KARTALCI ŞÜKRÜ,SÖZENA Mustafa Mert Association analysis of two polymorphisms in neuregulin-1 gene in a Turkish schizophrenia sample. , 2022, ss.1005 - 1008. 10.5455/annalsmedres.2022.03.104
AMA	Saygılı A,KARTALCI Ş,SÖZENA M Association analysis of two polymorphisms in neuregulin-1 gene in a Turkish schizophrenia sample. . 2022; 1005 - 1008. 10.5455/annalsmedres.2022.03.104
Vancouver	Saygılı A,KARTALCI Ş,SÖZENA M Association analysis of two polymorphisms in neuregulin-1 gene in a Turkish schizophrenia sample. . 2022; 1005 - 1008. 10.5455/annalsmedres.2022.03.104
IEEE	Saygılı A,KARTALCI Ş,SÖZENA M "Association analysis of two polymorphisms in neuregulin-1 gene in a Turkish schizophrenia sample." , ss.1005 - 1008, 2022. 10.5455/annalsmedres.2022.03.104
ISNAD	Saygılı, Ayşenur vd. "Association analysis of two polymorphisms in neuregulin-1 gene in a Turkish schizophrenia sample". (2022), 1005-1008. https://doi.org/10.5455/annalsmedres.2022.03.104

APA	Saygılı A, KARTALCI Ş, SÖZENA M (2022). Association analysis of two polymorphisms in neuregulin-1 gene in a Turkish schizophrenia sample. Annals of Medical Research, 29(9), 1005 - 1008. 10.5455/annalsmedres.2022.03.104
Chicago	Saygılı Ayşenur,KARTALCI ŞÜKRÜ,SÖZENA Mustafa Mert Association analysis of two polymorphisms in neuregulin-1 gene in a Turkish schizophrenia sample. Annals of Medical Research 29, no.9 (2022): 1005 - 1008. 10.5455/annalsmedres.2022.03.104
MLA	Saygılı Ayşenur,KARTALCI ŞÜKRÜ,SÖZENA Mustafa Mert Association analysis of two polymorphisms in neuregulin-1 gene in a Turkish schizophrenia sample. Annals of Medical Research, vol.29, no.9, 2022, ss.1005 - 1008. 10.5455/annalsmedres.2022.03.104
AMA	Saygılı A,KARTALCI Ş,SÖZENA M Association analysis of two polymorphisms in neuregulin-1 gene in a Turkish schizophrenia sample. Annals of Medical Research. 2022; 29(9): 1005 - 1008. 10.5455/annalsmedres.2022.03.104
Vancouver	Saygılı A,KARTALCI Ş,SÖZENA M Association analysis of two polymorphisms in neuregulin-1 gene in a Turkish schizophrenia sample. Annals of Medical Research. 2022; 29(9): 1005 - 1008. 10.5455/annalsmedres.2022.03.104
IEEE	Saygılı A,KARTALCI Ş,SÖZENA M "Association analysis of two polymorphisms in neuregulin-1 gene in a Turkish schizophrenia sample." Annals of Medical Research, 29, ss.1005 - 1008, 2022. 10.5455/annalsmedres.2022.03.104
ISNAD	Saygılı, Ayşenur vd. "Association analysis of two polymorphisms in neuregulin-1 gene in a Turkish schizophrenia sample". Annals of Medical Research 29/9 (2022), 1005-1008. https://doi.org/10.5455/annalsmedres.2022.03.104