The Effect of Convalescent Plasma Infusion in the Intensive Care Unit on Mortality of COVID-19 Patients: A Retrospective Cohort Study

Bilgili, Beliz; Oktay, Burçin Doruk; Cinel, Ismail; Sabaz, Mehmet Süleyman; Kaplan, Safiye Tuba; Gul, Fethi

doi:10.4274/tybd.galenos.2022.63634

The Effect of Convalescent Plasma Infusion in the Intensive Care Unit on Mortality of COVID-19 Patients: A Retrospective Cohort Study

Süleyman SABAZ, (Marmara Üniversitesi Pendik Eğitim ve Araştırma Hastane, Anesteziyoloji ve Reanimasyon Kliniği, Yoğun Bakım Anabilim Dalı, İstanbul, Türkiye)

Fethi GÜL, (Marmara Üniversitesi Tıp Fakültesi Anabilim Dalı Anesteziyoloji ve Reanimasyon Anabilim Dalı Yoğun Bakım Tıbbı, İstanbul, Türkiye)

Beliz BİLGİLİ, (Marmara Üniversitesi Pendik Eğitim ve Araştırma Hastane, Anesteziyoloji ve Reanimasyon Kliniği, Yoğun Bakım Anabilim Dalı, İstanbul, Türkiye)

Safiye Tuba KAPLAN, (Marmara Üniversitesi Pendik Eğitim ve Araştırma Hastane, Anesteziyoloji ve Reanimasyon Kliniği, Yoğun Bakım Anabilim Dalı, İstanbul, Türkiye)

Burçin DORUK OKTAY, (Marmara Üniversitesi Pendik Eğitim ve Araştırma Hastane, Anesteziyoloji ve Reanimasyon Kliniği, Yoğun Bakım Anabilim Dalı, İstanbul, Türkiye)

İsmail CİNEL (Marmara Üniversitesi Pendik Eğitim ve Araştırma Hastane, Anesteziyoloji ve Reanimasyon Kliniği, Yoğun Bakım Anabilim Dalı, İstanbul, Türkiye)

Türk Yoğun Bakım Dergisi

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Yıl: 2022 Cilt: 20 Sayı: Ek 1 Sayfa Aralığı: 135 - 146 Metin Dili: İngilizce DOI: 10.4274/tybd.galenos.2022.63634 İndeks Tarihi: 11-10-2022

The Effect of Convalescent Plasma Infusion in the Intensive Care Unit on Mortality of COVID-19 Patients: A Retrospective Cohort Study

Öz:

Objective: This study investigates the effect of convalescent plasma (CP) addition to the standard treatment on mortality in critical coronavirus disease-2019 (COVID-19) patients. Materials and Methods: This retrospective cohort study was conducted by evaluating the data of 255 critical COVID-19 patients in Marmara University Medical Faculty Hospital, Pandemic Intensive Care Unit (ICU), between April and November 2020. Results: The patients were divided into two groups, a control group that received standard treatment (153; 60.0%) versus a second group that received CP in addition to standard treatment (102; 40.0%). The ICU mortality rate was found to be lower (p<0.05) in patients receiving CP (38; 37.3%) compared to patients not receiving CP (79; 51.6%). The use of CP was found to reduce the probability of ICU mortality in patients with Acute Physiology and Chronic Health Evaluation-II (APACHE-II) score ≤10 [odds ratio (OR): 0.251; confidence interval (CI) 95%: 0.063-0.994, p=0.049) and APACHE-II score 11-14 (OR: 0.237; CI 95%: 0.066-0.844, p=0.026). CP transfusion, however, did not reduce the mortality in patients with an APACHE-II score of 15 and above. Furthermore, each day of delay in CP transfusion was found to increase the probability of mortality by 1.3 times (OR: 1.369; CI 95%: 1.155-1.622, p<0.001). Conclusion: The addition of CP to standard treatment in COVID-19 patients followed in ICU reduces mortality.

Anahtar Kelime:

Yoğun Bakım Ünitesinde Konvelesan Plazma İnfüzyonunun COVİD-19 Hastalarının Mortalitesi Üzerinde Etkisi: Retrospektif Bir Kohort Çalışması

Öz:

Amaç: Bu çalışmada yoğun bakım ünitesinde (YBÜ) kritik koronavirüs hastalığı-2019 (COVİD- 19) hastalarında standart tedaviye eklenen konvelesan plazma (CP) uygulamasının mortaliteye olan etkisi araştırıldı. Gereç ve Yöntem: Retrospektif kohort şeklinde planlanan bu çalışma 1 Nisan 2020-1 Kasım 2020 tarihleri arasında Marmara Üniversitesi Tıp Fakültesi Hastanesi, Pandemi YBÜ’de, 255 kritik COVİD- 19 hastasının verileri değerlendirilerek gerçekleştirildi. Bulgular: Hastalar standart tedavi alan hastalar (153; %60,0) ve CP alan hastalar (102; %40,0) olarak 2 gruba ayrıldılar. YBÜ mortalite oranı CP alan hastalarda (38; %37,3), almayanlara göre (79; %51,6) daha düşük bulundu (p<0,05). Akut Fizyoloji ve Kronik Sağlık Değerlendirmesi-II (APACHE-II) skoru ≤10 olan [olasılık oranı (OR): 0,251; güven aralığı (CI) %95: 0,063-0,994, p=0,049)] ve APACHE-II skoru 11-14 olan (OR): 0,237; %95: 0,066-0,844, p=0,026 hastalarda CP tedavisinin YBÜ mortalite olasılığını düşürdüğü belirlendi. APACHE-II skoru 15 ve üzerinde olan hastalarda CP transfüzyonunun mortaliteyi düşürmediği saptandı. Ayrıca CP transfüzyonundaki her bir günlük gecikmenin mortalite olasılığını 1,3 kat arttırdığı (OR: 1,369; CI %95: 1,155-1,622, p<0,001) belirlendi. Sonuç: YBÜ’de takip edilen COVİD-19 hastalarında standart tedaviye ek olarak CP kullanımı mortaliteyi düşürmektedir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Sabaz M, Gul F, Bilgili B, Kaplan S, Oktay B, Cinel I (2022). The Effect of Convalescent Plasma Infusion in the Intensive Care Unit on Mortality of COVID-19 Patients: A Retrospective Cohort Study. , 135 - 146. 10.4274/tybd.galenos.2022.63634
Chicago	Sabaz Mehmet Süleyman,Gul Fethi,Bilgili Beliz,Kaplan Safiye Tuba,Oktay Burçin Doruk,Cinel Ismail The Effect of Convalescent Plasma Infusion in the Intensive Care Unit on Mortality of COVID-19 Patients: A Retrospective Cohort Study. (2022): 135 - 146. 10.4274/tybd.galenos.2022.63634
MLA	Sabaz Mehmet Süleyman,Gul Fethi,Bilgili Beliz,Kaplan Safiye Tuba,Oktay Burçin Doruk,Cinel Ismail The Effect of Convalescent Plasma Infusion in the Intensive Care Unit on Mortality of COVID-19 Patients: A Retrospective Cohort Study. , 2022, ss.135 - 146. 10.4274/tybd.galenos.2022.63634
AMA	Sabaz M,Gul F,Bilgili B,Kaplan S,Oktay B,Cinel I The Effect of Convalescent Plasma Infusion in the Intensive Care Unit on Mortality of COVID-19 Patients: A Retrospective Cohort Study. . 2022; 135 - 146. 10.4274/tybd.galenos.2022.63634
Vancouver	Sabaz M,Gul F,Bilgili B,Kaplan S,Oktay B,Cinel I The Effect of Convalescent Plasma Infusion in the Intensive Care Unit on Mortality of COVID-19 Patients: A Retrospective Cohort Study. . 2022; 135 - 146. 10.4274/tybd.galenos.2022.63634
IEEE	Sabaz M,Gul F,Bilgili B,Kaplan S,Oktay B,Cinel I "The Effect of Convalescent Plasma Infusion in the Intensive Care Unit on Mortality of COVID-19 Patients: A Retrospective Cohort Study." , ss.135 - 146, 2022. 10.4274/tybd.galenos.2022.63634
ISNAD	Sabaz, Mehmet Süleyman vd. "The Effect of Convalescent Plasma Infusion in the Intensive Care Unit on Mortality of COVID-19 Patients: A Retrospective Cohort Study". (2022), 135-146. https://doi.org/10.4274/tybd.galenos.2022.63634

APA	Sabaz M, Gul F, Bilgili B, Kaplan S, Oktay B, Cinel I (2022). The Effect of Convalescent Plasma Infusion in the Intensive Care Unit on Mortality of COVID-19 Patients: A Retrospective Cohort Study. Türk Yoğun Bakım Dergisi, 20(Ek 1), 135 - 146. 10.4274/tybd.galenos.2022.63634
Chicago	Sabaz Mehmet Süleyman,Gul Fethi,Bilgili Beliz,Kaplan Safiye Tuba,Oktay Burçin Doruk,Cinel Ismail The Effect of Convalescent Plasma Infusion in the Intensive Care Unit on Mortality of COVID-19 Patients: A Retrospective Cohort Study. Türk Yoğun Bakım Dergisi 20, no.Ek 1 (2022): 135 - 146. 10.4274/tybd.galenos.2022.63634
MLA	Sabaz Mehmet Süleyman,Gul Fethi,Bilgili Beliz,Kaplan Safiye Tuba,Oktay Burçin Doruk,Cinel Ismail The Effect of Convalescent Plasma Infusion in the Intensive Care Unit on Mortality of COVID-19 Patients: A Retrospective Cohort Study. Türk Yoğun Bakım Dergisi, vol.20, no.Ek 1, 2022, ss.135 - 146. 10.4274/tybd.galenos.2022.63634
AMA	Sabaz M,Gul F,Bilgili B,Kaplan S,Oktay B,Cinel I The Effect of Convalescent Plasma Infusion in the Intensive Care Unit on Mortality of COVID-19 Patients: A Retrospective Cohort Study. Türk Yoğun Bakım Dergisi. 2022; 20(Ek 1): 135 - 146. 10.4274/tybd.galenos.2022.63634
Vancouver	Sabaz M,Gul F,Bilgili B,Kaplan S,Oktay B,Cinel I The Effect of Convalescent Plasma Infusion in the Intensive Care Unit on Mortality of COVID-19 Patients: A Retrospective Cohort Study. Türk Yoğun Bakım Dergisi. 2022; 20(Ek 1): 135 - 146. 10.4274/tybd.galenos.2022.63634
IEEE	Sabaz M,Gul F,Bilgili B,Kaplan S,Oktay B,Cinel I "The Effect of Convalescent Plasma Infusion in the Intensive Care Unit on Mortality of COVID-19 Patients: A Retrospective Cohort Study." Türk Yoğun Bakım Dergisi, 20, ss.135 - 146, 2022. 10.4274/tybd.galenos.2022.63634
ISNAD	Sabaz, Mehmet Süleyman vd. "The Effect of Convalescent Plasma Infusion in the Intensive Care Unit on Mortality of COVID-19 Patients: A Retrospective Cohort Study". Türk Yoğun Bakım Dergisi 20/Ek 1 (2022), 135-146. https://doi.org/10.4274/tybd.galenos.2022.63634