Familial Mediterranean fever (FMF) is the most common hereditary autoinflammatory disease worldwide and is characterized by recurrent fever and serositis. Serum soluble receptor for advanced glycation end products (sRAGE) is an isoform of RAGE and sRAGE acts as a trap receptor for ligands and blocks the RAGE–ligand axis. This study aimed to examine the change in sRAGE levels in FMF and to investigate its relationship with inflammation. This study included patients with FMF (n=20) and healthy controls (n=22). Morbidity status, sRAGE levels, demographic and laboratory data were recorded. Pregnant women, individuals aged <18 years, and those with other chronic inflammatory diseases were excluded. Statistical Package for Social Sciences (SPSS) Version 22.0 was used to conduct all statistical analyses and all data are expressed as mean and standard deviation (SD). The serum sRAGE levels were 12.21±6.70 ng/mL and 4.44±2.89 ng/mL in the patient and control groups, respectively. Accordingly, the sRAGE levels of patients with FMF were significantly higher (p<0.001). Comorbidities had no effect on the sRAGE levels of the patient group and no correlation was found between the sRAGE and inflammatory biomarkers. sRAGE levels are elevated in FMF but does not seem to be a promising candidate as a biomarker for FMF.