Cytotoxic effect of azole compounds bearing trifluorophenyl ring on MCF-7, MDA-MB-231, and HCT-116 cancer cell line
Yıl: 2022 Cilt: 11 Sayı: 3 Sayfa Aralığı: 1212 - 1216 Metin Dili: İngilizce DOI: 10.5455/medscience.2022.04.085 İndeks Tarihi: 12-10-2022
Cytotoxic effect of azole compounds bearing trifluorophenyl ring on MCF-7, MDA-MB-231, and HCT-116 cancer cell line
Öz: Cancer, a disease defined by rapid proliferation of cells, still remains one of the most feared diseases of the modern world. Many structurally different anti-carcinogenic drugs are used in several tumor types such as bladder, colon, ovary, breast, head and neck, testis, lung and prostate cancer. In this study, cytotoxic effects of the compounds with different linkers (ketone, oxime, alcohol, chlorine) between pyrazole and trifluoromethyl on MCF-7 (human breast adenocarcinoma), MDA-MB-231 (human breast adenocarcinoma), and HCT-116 (human colon cancer) cell lines were investigated. Compound a1 was observed to be the most potent compound with IC50 values of 5.84±0.76, 5.01±0.32, 5.57±0.02 µg.ml-1 against these cell lines, respectively. It was found that all compounds were very effective against all the tested cancer cell lines.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | alagöz m, Özdemir Z, KARAKURT A, hepokur c (2022). Cytotoxic effect of azole compounds bearing trifluorophenyl ring on MCF-7, MDA-MB-231, and HCT-116 cancer cell line. , 1212 - 1216. 10.5455/medscience.2022.04.085 |
| Chicago | alagöz mehmet abdullah,Özdemir Zeynep,KARAKURT Arzu,hepokur ceylan Cytotoxic effect of azole compounds bearing trifluorophenyl ring on MCF-7, MDA-MB-231, and HCT-116 cancer cell line. (2022): 1212 - 1216. 10.5455/medscience.2022.04.085 |
| MLA | alagöz mehmet abdullah,Özdemir Zeynep,KARAKURT Arzu,hepokur ceylan Cytotoxic effect of azole compounds bearing trifluorophenyl ring on MCF-7, MDA-MB-231, and HCT-116 cancer cell line. , 2022, ss.1212 - 1216. 10.5455/medscience.2022.04.085 |
| AMA | alagöz m,Özdemir Z,KARAKURT A,hepokur c Cytotoxic effect of azole compounds bearing trifluorophenyl ring on MCF-7, MDA-MB-231, and HCT-116 cancer cell line. . 2022; 1212 - 1216. 10.5455/medscience.2022.04.085 |
| Vancouver | alagöz m,Özdemir Z,KARAKURT A,hepokur c Cytotoxic effect of azole compounds bearing trifluorophenyl ring on MCF-7, MDA-MB-231, and HCT-116 cancer cell line. . 2022; 1212 - 1216. 10.5455/medscience.2022.04.085 |
| IEEE | alagöz m,Özdemir Z,KARAKURT A,hepokur c "Cytotoxic effect of azole compounds bearing trifluorophenyl ring on MCF-7, MDA-MB-231, and HCT-116 cancer cell line." , ss.1212 - 1216, 2022. 10.5455/medscience.2022.04.085 |
| ISNAD | alagöz, mehmet abdullah vd. "Cytotoxic effect of azole compounds bearing trifluorophenyl ring on MCF-7, MDA-MB-231, and HCT-116 cancer cell line". (2022), 1212-1216. https://doi.org/10.5455/medscience.2022.04.085 |
| APA | alagöz m, Özdemir Z, KARAKURT A, hepokur c (2022). Cytotoxic effect of azole compounds bearing trifluorophenyl ring on MCF-7, MDA-MB-231, and HCT-116 cancer cell line. Medicine Science, 11(3), 1212 - 1216. 10.5455/medscience.2022.04.085 |
| Chicago | alagöz mehmet abdullah,Özdemir Zeynep,KARAKURT Arzu,hepokur ceylan Cytotoxic effect of azole compounds bearing trifluorophenyl ring on MCF-7, MDA-MB-231, and HCT-116 cancer cell line. Medicine Science 11, no.3 (2022): 1212 - 1216. 10.5455/medscience.2022.04.085 |
| MLA | alagöz mehmet abdullah,Özdemir Zeynep,KARAKURT Arzu,hepokur ceylan Cytotoxic effect of azole compounds bearing trifluorophenyl ring on MCF-7, MDA-MB-231, and HCT-116 cancer cell line. Medicine Science, vol.11, no.3, 2022, ss.1212 - 1216. 10.5455/medscience.2022.04.085 |
| AMA | alagöz m,Özdemir Z,KARAKURT A,hepokur c Cytotoxic effect of azole compounds bearing trifluorophenyl ring on MCF-7, MDA-MB-231, and HCT-116 cancer cell line. Medicine Science. 2022; 11(3): 1212 - 1216. 10.5455/medscience.2022.04.085 |
| Vancouver | alagöz m,Özdemir Z,KARAKURT A,hepokur c Cytotoxic effect of azole compounds bearing trifluorophenyl ring on MCF-7, MDA-MB-231, and HCT-116 cancer cell line. Medicine Science. 2022; 11(3): 1212 - 1216. 10.5455/medscience.2022.04.085 |
| IEEE | alagöz m,Özdemir Z,KARAKURT A,hepokur c "Cytotoxic effect of azole compounds bearing trifluorophenyl ring on MCF-7, MDA-MB-231, and HCT-116 cancer cell line." Medicine Science, 11, ss.1212 - 1216, 2022. 10.5455/medscience.2022.04.085 |
| ISNAD | alagöz, mehmet abdullah vd. "Cytotoxic effect of azole compounds bearing trifluorophenyl ring on MCF-7, MDA-MB-231, and HCT-116 cancer cell line". Medicine Science 11/3 (2022), 1212-1216. https://doi.org/10.5455/medscience.2022.04.085 |
