TY  - JOUR
TI  - Cytotoxic effect of azole compounds bearing trifluorophenyl ring on MCF-7, MDA-MB-231, and HCT-116 cancer cell line
AB  - Cancer, a disease defined by rapid proliferation of cells, still remains one of the most feared diseases of the modern world. Many structurally different anti-carcinogenic drugs are used in several tumor types such as bladder, colon, ovary, breast, head and neck, testis, lung and prostate cancer. In this study, cytotoxic effects of the compounds with different linkers (ketone, oxime, alcohol, chlorine) between pyrazole and trifluoromethyl on MCF-7 (human breast adenocarcinoma), MDA-MB-231 (human breast adenocarcinoma), and HCT-116 (human colon cancer) cell lines were investigated. Compound a1 was observed to be the most potent compound with IC50 values of 5.84±0.76, 5.01±0.32, 5.57±0.02 µg.ml-1 against these cell lines, respectively. It was found that all compounds were very effective against all the tested cancer cell lines.
AU  - alagöz, mehmet abdullah
AU  - Özdemir, Zeynep
AU  - hepokur, ceylan
AU  - KARAKURT, Arzu
DO  - 10.5455/medscience.2022.04.085
PY  - 2022
JO  - Medicine Science
VL  - 11
IS  - 3
SN  - 2147-0634
SP  - 1212
EP  - 1216
DB  - TRDizin
UR  - http://search/yayin/detay/1131323
ER  -