In vitro Evaluation of Antigenotoxic Effects of Phloridzin

Mehmet Sarimahmut, (Bursa Uludağ Üniversitesi, Fen-Edebiyat Fakültesi, Biyoloji Bölümü, Bursa, Türkiye)
Sindi Vekshari, (Bursa Uludağ Üniversitesi, Fen-Edebiyat Fakültesi, Biyoloji Bölümü, Bursa, Türkiye)
Merve DEMİRBAĞ KARAALİ, (Bursa Uludağ Üniversitesi, Fen-Edebiyat Fakültesi, Biyoloji Bölümü, Bursa, Türkiye)
Serap ÇELİKLER (Bursa Uludağ Üniversitesi, Fen-Edebiyat Fakültesi, Biyoloji Bölümü, Bursa, Türkiye)
Cumhuriyet Science Journal
1 0
Yıl: 2022 Cilt: 43 Sayı: 3 Sayfa Aralığı: 358 - 364 Metin Dili: İngilizce DOI: 10.17776/csj.1035449 İndeks Tarihi: 14-10-2022

In vitro Evaluation of Antigenotoxic Effects of Phloridzin

Öz:
Phytochemicals have a vast number of properties contributing to human health by acting on numerous different mechanisms. Phloridzin, a phytochemical mainly found in Malus species, possesses diverse biological activities including anti-diabetic and antioxidative activities. Here, our aim is to explore antigenotoxic potential and proliferative effects of phloridzin on human lymphocytes in vitro by employing chromosome aberration, micronucleus and comet assays. Mitomycin C, both an anticancer and genotoxic agent, was utilized to induce genotoxicity. Phloridzin significantly suppressed the genotoxic effects of mitomycin C at 125-500 µg/mL concentrations in all assays used (p < 0.05). We also revealed that phloridzin and mitomycin C combination had a significantly negative effect on mitotic index (p < 0.05), whereas in general, gender differences did not play a role in manifestation of neither antigenotoxic nor antiproliferative activities of the combination.These results suggest that phloridzin is an antigenotoxic compound and its consumption may interfere with the activity of anticancer drugs that exert their effects based on genotoxic mechanisms.
Anahtar Kelime: Phlorizin Genotoxicity Mitomycin C Chromosome aberration.

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APA Sarimahmut M, Vekshari S, Demirbağ Karaali M, Çelikler S (2022). In vitro Evaluation of Antigenotoxic Effects of Phloridzin. , 358 - 364. 10.17776/csj.1035449
Chicago Sarimahmut Mehmet,Vekshari Sindi,Demirbağ Karaali Merve,Çelikler Serap In vitro Evaluation of Antigenotoxic Effects of Phloridzin. (2022): 358 - 364. 10.17776/csj.1035449
MLA Sarimahmut Mehmet,Vekshari Sindi,Demirbağ Karaali Merve,Çelikler Serap In vitro Evaluation of Antigenotoxic Effects of Phloridzin. , 2022, ss.358 - 364. 10.17776/csj.1035449
AMA Sarimahmut M,Vekshari S,Demirbağ Karaali M,Çelikler S In vitro Evaluation of Antigenotoxic Effects of Phloridzin. . 2022; 358 - 364. 10.17776/csj.1035449
Vancouver Sarimahmut M,Vekshari S,Demirbağ Karaali M,Çelikler S In vitro Evaluation of Antigenotoxic Effects of Phloridzin. . 2022; 358 - 364. 10.17776/csj.1035449
IEEE Sarimahmut M,Vekshari S,Demirbağ Karaali M,Çelikler S "In vitro Evaluation of Antigenotoxic Effects of Phloridzin." , ss.358 - 364, 2022. 10.17776/csj.1035449
ISNAD Sarimahmut, Mehmet vd. "In vitro Evaluation of Antigenotoxic Effects of Phloridzin". (2022), 358-364. https://doi.org/10.17776/csj.1035449
APA Sarimahmut M, Vekshari S, Demirbağ Karaali M, Çelikler S (2022). In vitro Evaluation of Antigenotoxic Effects of Phloridzin. Cumhuriyet Science Journal, 43(3), 358 - 364. 10.17776/csj.1035449
Chicago Sarimahmut Mehmet,Vekshari Sindi,Demirbağ Karaali Merve,Çelikler Serap In vitro Evaluation of Antigenotoxic Effects of Phloridzin. Cumhuriyet Science Journal 43, no.3 (2022): 358 - 364. 10.17776/csj.1035449
MLA Sarimahmut Mehmet,Vekshari Sindi,Demirbağ Karaali Merve,Çelikler Serap In vitro Evaluation of Antigenotoxic Effects of Phloridzin. Cumhuriyet Science Journal, vol.43, no.3, 2022, ss.358 - 364. 10.17776/csj.1035449
AMA Sarimahmut M,Vekshari S,Demirbağ Karaali M,Çelikler S In vitro Evaluation of Antigenotoxic Effects of Phloridzin. Cumhuriyet Science Journal. 2022; 43(3): 358 - 364. 10.17776/csj.1035449
Vancouver Sarimahmut M,Vekshari S,Demirbağ Karaali M,Çelikler S In vitro Evaluation of Antigenotoxic Effects of Phloridzin. Cumhuriyet Science Journal. 2022; 43(3): 358 - 364. 10.17776/csj.1035449
IEEE Sarimahmut M,Vekshari S,Demirbağ Karaali M,Çelikler S "In vitro Evaluation of Antigenotoxic Effects of Phloridzin." Cumhuriyet Science Journal, 43, ss.358 - 364, 2022. 10.17776/csj.1035449
ISNAD Sarimahmut, Mehmet vd. "In vitro Evaluation of Antigenotoxic Effects of Phloridzin". Cumhuriyet Science Journal 43/3 (2022), 358-364. https://doi.org/10.17776/csj.1035449
Sayfa Oluşturulma Tarihi
24-04-2024 18:44

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