Effectiveness of laparoscopic gastrectomy in elderly patients with locally advanced gastric cancer

Serdar ÇULCU, (Ankara Üniversitesi,Tıp Fakültesi, Cerrahi Onkoloji Anabilim Dalı, Ankara, Türkiye)
Selim TAMAM, (Ankara Üniversitesi,Tıp Fakültesi, Cerrahi Onkoloji Anabilim Dalı, Ankara, Türkiye)
Cem AZILI, (Ankara Üniversitesi,Tıp Fakültesi, Cerrahi Onkoloji Anabilim Dalı, Ankara, Türkiye)
Zeynep KOCA, (Ankara Üniversitesi,Tıp Fakültesi, Ankara, Türkiye)
Ali Ekrem ÜNAL, (Ankara Üniversitesi,Tıp Fakültesi, Cerrahi Onkoloji Anabilim Dalı, Ankara, Türkiye)
Salim DEMİRCİ (Ankara Üniversitesi,Tıp Fakültesi, Cerrahi Onkoloji Anabilim Dalı, Ankara, Türkiye)
Laparoscopic Endoscopic Surgical Science
6 2
Yıl: 2022 Cilt: 29 Sayı: 3 Sayfa Aralığı: 161 - 170 Metin Dili: İngilizce DOI: 10.14744/less.2022.25991 İndeks Tarihi: 16-10-2022

Effectiveness of laparoscopic gastrectomy in elderly patients with locally advanced gastric cancer

Öz:
Introduction: The benefits of laparoscopic gastrectomy in elderly patients with locally advanced gastric cancer remain unclear. The aim of this study was to evaluate the results and feasibility of laparoscopic gastrectomy in patients with locally advanced gastric cancer. Materials and Methods: We retrospectively reviewed that 461 consecutive patient mean survival follow-up times in elderly patients who underwent laparoscopic gastrectomy were similar to those who underwent open gastrectomy and younger patients who underwent laparoscopic gastrectomy those who underwent curative gastrectomy for locally advanced gastric cancer in our institution between January 2010 and December 2020. Short-term outcomes and mean survival follow-up times were compared between the elderly – young and open – laparoscopic groups. Results: Except for the length of stay in the hospital and intensive care unit, all outcomes were similar in elderly patients who underwent laparoscopic gastrectomy to those who underwent open gastrectomy. Length of stay in hospital and intensive care unit was significantly shorter in patients who underwent laparoscopic gastrectomy. No significant difference was observed in terms of intensive care unit length of stay, total length of hospital stay, complication rates, mortality rates, and oncologic outcomes between elderly and young patients who underwent laparoscopy. Conclusion: Laparoscopic surgery is a feasible and safe procedure with acceptable postoperative morbidity and survival rates in elderly patients with locally advanced gastric cancer.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • -Konishi H, Ichikawa D, Itoh H, Fukuda K, Kakihara N, Take mura M, et al. Surgery for gastric cancer patients of age 85 and older: Multicenter survey. World J Gastroenterol 2017;23:1215–23.
  • Liu KT, Wan JF, Yu GH, Bei YP, Chen X, Lu MZ. The recommended treatment strategy for locally advanced gastric cancer in elderly patients aged 75 years and older: a surveillance, epidemiology, and end results database analysis. J Cancer Res Clin Oncol 2017;143:313–20.
  • Kim MS, Kim S. Outcome of gastric cancer surgery in elderly patients. J Gastric Cancer 2016;16:254–9.
  • Shimada S, Sawada N, Oae S, Seki J, Takano Y, Ishiyama Y, et al. Safety and curability of laparoscopic gastrectomy in elderly patients with gastric cancer. Surg Endosc 2018;32:4277–83.
  • Liu P, Li C, Wang Y, Zeng W, Wang H, Wu H, et al. The impact of the major causes of death on life expectancy in China: a 60-year longitudinal study. BMC Public Health 2014;14:1193.
  • Tekesin K, Emin Gunes M, Tural D, Akar E, Zirtiloglu A, Karaca M, et al. Clinicopathological characteristics, prognosis and survival outcome of gastric cancer in young patients: A large cohort retrospective study. J BUON 2019;24:672–8.
  • Nienhueser H, Kunzmann R, Sisic L, Blank S, Strowitzk MJ, Bruckner T, et al. Surgery of gastric cancer and esophageal cancer: Does age matter? J Surg Oncol 2015;112:387–95.
  • Pan Y, Chen K, Yu WH, Maher H, Wang SH, Zhao HF, et al. Laparoscopic gastrectomy for elderly patients with gastric cancer: A systematic review with meta-analysis. Medicine (Baltimore) 2018;97:e0007.
  • Suematsu H, Kunisaki C, Miyamato H, Sato K, Sato S, Tanaka Y, et al. Laparoscopic total gastrectomy for gastric cancer in elderly patients. In Vivo 2020;34:2933–9.
  • Saito H, Osaki T, Murakami D, Sakamoto T, Kanaji S, Tatebe S, et al. Effect of age on prognosis in patients with gastric cancer. ANZ J Surg 2006;76:458–61.
  • Kim W, Kim HH, Han SU, Kim MC, Hyung WJ, Ryu SW, et al. Decreased morbidity of laparoscopic distal gastrectomy compared with open distal gastrectomy for stage I gastric Cancer short- term outcomes from a multicenter randomized controlled trial (KLASS-01). Ann Surg 2016;263:28–35.
  • Hu YF, Ying MG, Huang CM, Wei HB, Jiang ZW, Peng X, et al. Oncologic outcomes of laparoscopy-assisted gastrectomy for advanced gastric cancer: a large scale multicenter retrospective cohort study from China. Surg Endosc 2014;28:2048–56.
  • HuYF, Huang CM, Sun YH, Su XQ, Cao H, Hu JK, et al. Morbidity and mortality of laparoscopic versus open D2 distal gastrectomy for advanced gastric Cancer: a randomized controlled trial. J Clin Oncol 2016;34:1350.
  • Otsuji E, Fujiyama J, Takagi T, Ito T, Kuriu Y, Toma A, et al. Results of total gastrectomy with extended lymphadenectomy for gastric cancer in elderly patients. J Surg Oncol 2005;91:232–6.
  • Hager ES, Abdollahi H, Crawford AG, Moudgill N, Rosato EL, Chojnacki KA, et al. Is gastrectomy safe in the elderly? A single institution review. Am Surg 2011;77:488–92.
  • Zhou CJ, Chen FF, Zhuang CL, Pang WY, Zhang FY, Huang DD, et al. Feasibility of radical gastrectomy for elderly patients with gastric cancer. Eur J Surg Oncol 2016;42:303–11.
  • Jung HS, Park YK, Ryu SY, Jeong O. Laparoscopic total gastrectomy in elderly patients (≥70 years) with gastric carcinoma: a retrospective study. J Gastric Cancer 2015;15:176– 82.
  • Lu J, Huang CM, Zheng CH, Li P, Xie JW, Wang JB, et al. Short- and long-term outcomes after laparoscopic versus open total gastrectomy for elderly gastric cancer patients: a propensity score-matched analysis. J Gastrointest Surg 2015;19:1949–57.
  • Clavien PA, Barkun J, de Oliveira ML, Vauthey JN, Dindo D, Schulick RD, et al. The Clavien-Dindo classification of surgical complications: five-year experience. Ann Surg 2009;250:187–96.
  • Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 2004;240:205–13.
  • Cainap C, Vlad C, Seicean A, Balacescu O, Seicean R, Constantin AM, et al. Gastric cancer: adjuvant chemotherapy versus chemoradiation. A clinical point of view. J BUON 2019;24:2209–19.
  • Saif MW, Makrilia N, Zalonis A, Merikas M, Syrigos K. Gastric cancer in the elderly: an overview. Eur J Surg Oncol 2010;36:709–17.
  • Katai H, Mizusawa J, Katayama H, Morita S, Yamada T, Bando E, et al. Survival outcomes after laparoscopy-assisted distal gastrectomy versus open distal gastrectomy with nodal dissection for clinical stage IA or IB gastric cancer (JCOG0912): a multicentre, non-inferiority, phase 3 randomised controlled trial. Lancet Gastroenterol Hepatol 2020;5:142–51.
  • Kim HH, Han SU, Kim MC, Kim W, Lee HJ, Ryu SW, et al; Korean Laparoendoscopic Gastrointestinal Surgery Study (KLASS) Group. Effect of laparoscopic distal gastrectomy vs open distal gastrectomy on long-term survival among patients with stage I gastric cancer: The KLASS-01 randomized clinical trial. JAMA Oncol 2019;5:506–13.
  • Yamada H, Kojima K, Inokuchi M, Kawano T, Sugihara K. Laparoscopy-assisted gastrectomy in patients older than 80. J Surg Res 2010;161:259–63.
  • Mikami R, Tanaka E, Murakami T, Ishida S, Matsui Y, Horita K, et al. The safety and feasibility of laparoscopic gastrectomy for gastric cancer in very elderly patients: short-and longterm outcomes. Surg Today 2021;51:219–25.
  • Anegawa G, Nakashima Y, Fujinaka Y, Takahashi I. Laparoscopy-assisted distal gastrectomy for early gastric cancer poses few limitations for selected elderly patients: a single-center experience. Surg Case Rep 2016;2:56.
  • Hiki N, Katai H, Mizusawa J, Nakamura K, Nakamori M, Yoshikawa T, et al; Stomach Cancer Study Group of Japan Clinical Oncology Group. Long-term outcomes of laparoscopy-assisted distal gastrectomy with suprapancreatic nodal dissection for clinical stage I gastric cancer: a multicenter phase II trial (JCOG0703). Gastric Cancer 2018;21:155–61.
  • Shi Y, Xu X, Zhao Y, Qian F, Tang B, Hao Y, et al. Short-term surgical outcomes of a randomized controlled trial comparing laparoscopic versus open gastrectomy with D2 lymph node dissection for advanced gastric cancer. Surg Endosc 2018;32:2427–33.
  • Cai J, Wei D, Gao CF, Zhang CS, Zhang H, Zhao T. A prospective randomized study comparing open versus laparoscopyassisted D2 radical gastrectomy in advanced gastric cancer. Dig Surg 2011;28:331–7.
  • Inaki N, Etoh T, Ohyama T, Uchiyama K, Katada N, Koeda K, et al. A Multi-institutional, prospective, phase II feasibility study of laparoscopy-assisted distal gastrectomy with D2 lymph node dissection for locally advanced gastric cancer (JLSSG0901). World J Surg 2015;39:2734–41.
  • Park YK, Yoon HM, Kim YW, Park JY, Ryu KW, Lee YJ, et al; COACT group. Laparoscopy-assisted versus Open D2 distal gastrectomy for advanced gastric cancer: results from a randomized phase II multicenter clinical trial (COACT 1001). Ann Surg 2018;267:638–45.
  • Zeng YK, Yang ZL, Peng JS, Lin HS, Cai L. Laparoscopy-assisted versus open distal gastrectomy for early gastric cancer: evidence from randomized and nonrandomized clinical trials. Ann Surg 2012;256:39–52.
  • Zong L, Wu A, Wang W, Deng J, Aikou S, Yamashita H, et al. Feasibility of laparoscopic gastrectomy for elderly gastric cancer patients: meta-analysis of non-randomized controlled studies. Oncotarget 2017;8:51878–87.
  • Cuschieri A, Fayers P, Fielding J, Craven J, Bancewicz J, Joypaul V, et al. Postoperative morbidity and mortality after D1 and D2 resections for gastric cancer: preliminary results of the MRC randomised controlled surgical trial. The Surgical Cooperative Group. Lancet 1996;347:995–9.
  • Liang YX, Deng JY, Guo HH, Ding XW, Wang XN, Wang BG, et al. Characteristics and prognosis of gastric cancer in patients aged ≥ 70 years. World J Gastroenterol 2013;19:6568– 78.
  • Rausei S, Ruspi L, Rosa F, Morgagni P, Marrelli D, Cossu A, et al; Italian Research Group for Gastric Cancer (IRGGC). Extended lymphadenectomy in elderly and/or highly co-morbid gastric cancer patients: A retrospective multicenter study. Eur J Surg Oncol 2016;42:1881–9.
  • Takeshita H, Ichikawa D, Komatsu S, Kubota T, Okamoto K, Shiozaki A, et al. Surgical outcomes of gastrectomy for elderly patients with gastric cancer. World J Surg 2013;37:2891–8.
  • Aratani K, Sakuramoto S, Chuman M, Kasuya M, Wakata M, Miyawaki Y, et al. Laparoscopy-assisted Distal Gastrectomy for Gastric Cancer in Elderly Patients: Surgical Outcomes and Prognosis. Anticancer Res 2018;38:1721–5.
  • Zheng L, Lu L, Jiang X, Jian W, Liu Z, Zhou D. Laparoscopyassisted versus open distal gastrectomy for gastric cancer in elderly patients: a retrospective comparative study. Surg Endosc 2016;30:4069–77.
APA Culcu S, tamam s, Azılı C, Koca Z, Ünal A, Demirci S (2022). Effectiveness of laparoscopic gastrectomy in elderly patients with locally advanced gastric cancer. , 161 - 170. 10.14744/less.2022.25991
Chicago Culcu Serdar,tamam selim,Azılı Cem,Koca Zeynep,Ünal Ali Ekrem,Demirci Salim Effectiveness of laparoscopic gastrectomy in elderly patients with locally advanced gastric cancer. (2022): 161 - 170. 10.14744/less.2022.25991
MLA Culcu Serdar,tamam selim,Azılı Cem,Koca Zeynep,Ünal Ali Ekrem,Demirci Salim Effectiveness of laparoscopic gastrectomy in elderly patients with locally advanced gastric cancer. , 2022, ss.161 - 170. 10.14744/less.2022.25991
AMA Culcu S,tamam s,Azılı C,Koca Z,Ünal A,Demirci S Effectiveness of laparoscopic gastrectomy in elderly patients with locally advanced gastric cancer. . 2022; 161 - 170. 10.14744/less.2022.25991
Vancouver Culcu S,tamam s,Azılı C,Koca Z,Ünal A,Demirci S Effectiveness of laparoscopic gastrectomy in elderly patients with locally advanced gastric cancer. . 2022; 161 - 170. 10.14744/less.2022.25991
IEEE Culcu S,tamam s,Azılı C,Koca Z,Ünal A,Demirci S "Effectiveness of laparoscopic gastrectomy in elderly patients with locally advanced gastric cancer." , ss.161 - 170, 2022. 10.14744/less.2022.25991
ISNAD Culcu, Serdar vd. "Effectiveness of laparoscopic gastrectomy in elderly patients with locally advanced gastric cancer". (2022), 161-170. https://doi.org/10.14744/less.2022.25991
APA Culcu S, tamam s, Azılı C, Koca Z, Ünal A, Demirci S (2022). Effectiveness of laparoscopic gastrectomy in elderly patients with locally advanced gastric cancer. Laparoscopic Endoscopic Surgical Science, 29(3), 161 - 170. 10.14744/less.2022.25991
Chicago Culcu Serdar,tamam selim,Azılı Cem,Koca Zeynep,Ünal Ali Ekrem,Demirci Salim Effectiveness of laparoscopic gastrectomy in elderly patients with locally advanced gastric cancer. Laparoscopic Endoscopic Surgical Science 29, no.3 (2022): 161 - 170. 10.14744/less.2022.25991
MLA Culcu Serdar,tamam selim,Azılı Cem,Koca Zeynep,Ünal Ali Ekrem,Demirci Salim Effectiveness of laparoscopic gastrectomy in elderly patients with locally advanced gastric cancer. Laparoscopic Endoscopic Surgical Science, vol.29, no.3, 2022, ss.161 - 170. 10.14744/less.2022.25991
AMA Culcu S,tamam s,Azılı C,Koca Z,Ünal A,Demirci S Effectiveness of laparoscopic gastrectomy in elderly patients with locally advanced gastric cancer. Laparoscopic Endoscopic Surgical Science. 2022; 29(3): 161 - 170. 10.14744/less.2022.25991
Vancouver Culcu S,tamam s,Azılı C,Koca Z,Ünal A,Demirci S Effectiveness of laparoscopic gastrectomy in elderly patients with locally advanced gastric cancer. Laparoscopic Endoscopic Surgical Science. 2022; 29(3): 161 - 170. 10.14744/less.2022.25991
IEEE Culcu S,tamam s,Azılı C,Koca Z,Ünal A,Demirci S "Effectiveness of laparoscopic gastrectomy in elderly patients with locally advanced gastric cancer." Laparoscopic Endoscopic Surgical Science, 29, ss.161 - 170, 2022. 10.14744/less.2022.25991
ISNAD Culcu, Serdar vd. "Effectiveness of laparoscopic gastrectomy in elderly patients with locally advanced gastric cancer". Laparoscopic Endoscopic Surgical Science 29/3 (2022), 161-170. https://doi.org/10.14744/less.2022.25991
Sayfa Oluşturulma Tarihi
24-04-2024 4:3

İLETİŞİM

TÜBİTAK ULAKBİM TR Dizin

Yüzüncüyıl, İşçi Blokları Mahallesi

Muhsin Yazıcıoğlu Caddesi No:51/C

06530 Çankaya / ANKARA +90 (312) 298 92 00

trdizin@tubitak.gov.tr

TÜBİTAK ULAKBİM Ulusal Akademik Ağ ve Bilgi Merkezi Cahit Arf Bilgi Merkezi © Tüm Hakları Saklıdır. Gizlilik Politikası Kullanım Şartları