Aim: The aim of this study was to investigate the protective effects of diclofenac sodium (DF) and montelukast sodium (ML) on acute inflammation in traumatic spinal cord injury (T-SCI). Materials and Methods: Forty Sprague-Dawley rats were randomly divided into five groups. While no intervention was made in the control group, spinal cord injury was applied to the trauma group. DF, ML and DF+ML were administered intraperitoneally to the remaining three groups after trauma. After rats were sacrificed, tissue samples containing both spinal cord and dura were subjected to histopathological examination and scored for edema, necrosis, inflammatory cells, apoptosis, neuron damage, and bleeding. Results: There was a significant difference in the histopathological changes between the control and trauma groups (p<0.05). Histopathological scores of the trauma group and trauma+drug groups were similar (p>0.05). In the comparison of the control group and the other groups, no significant difference in edema was found in the tDF group (p=0.059). When the inflammatory cells were examined, it was seen that the cell amount was the least in the tDF group (p=0.068). It was observed that necrosis (p=0.1), apoptosis (p=0.061) and neural damage status (p=0.139) were the least in the tDF+ML combined group. There was no significant difference between the groups in terms of the amount of bleeding (p>0.05). Conclusion: While the use of DF alone reduced the number of edema and inflammatory cells, the combined use of DF+ML reduced the development of necrosis, apoptosis and neural damage in T-SCI.