TY  - JOUR
TI  - Frequency of Direct Oral Anticoagulants Usage in Acute Pulmonary Thromboembolism Treatment in Turkey (TUPEDO)
AB  - Background: Direct oral anticoagulants (DOACs) have been used in acute pulmonary thromboembolism as an alternative to warfarin due to drug interactions, narrow therapeutic range, and necessary close International Normalized Ratio (INR) monitoring. Phase 3 study results have reported that these drugs are at least as effective as warfarin and beneficial in terms of bleeding; however, studies that present up-to-date life data are necessary. Aims: To evaluate the frequency of using DOACs, which are prescribed with a limited number of indications in our country, and real-life data results. Study Design: Cross-sectional study Methods: This cross-sectional survey collected the clinical data (history, current treatment, treatment duration, etc.) of patients with pulmonary thromboembolism and who applied to the physician for follow-up between October 15, 2019, and March 15, 2020. The researchers kept the patient records sequentially. Results: Data from 836 patients with acute pulmonary thromboembolism from 25 centers were collected, and DOAC was used in 320 (38.5%) of them. The most preferred DOAC was rivaroxaban (n = 294, 91.9%). DOAC was mostly preferred because it could not provide an effective INR level with warfarin (n=133, 41.6%). Bleeding was observed in 13 (4%) patients. Conclusion: The use of direct oral anticoagulants is becoming almost as widespread as conventional therapy. Real-life data results are important for their contribution to clinical practice.
AU  - özsarı, emine
AU  - Esendagli, Dorina
AU  - gülmez, inci
AU  - Yetkin, Nur Aleyna
AU  - Yilmazel Ucar, Elif
AU  - Uzer, Fatih
AU  - Tapan, Utku
AU  - Tanrıverdi, Elif
AU  - ŞAHİN, FÜSUN
AU  - Tabaru, Ali
AU  - Doğan, Deniz
AU  - Şentürk, Ayşegül
AU  - Karadeniz, Gülistan
AU  - YILDIRIM, ZEYNEP
AU  - Alzafer, Suha
AU  - çeldir emre, julide
AU  - Kurt, EMİNE BAHAR
AU  - Selimoğlu Şen, Hadice
AU  - Serçe Unat, Damla
AU  - Durmuş Koçak, Nagihan
AU  - tutar, nuri
AU  - yarar, esra
AU  - arınç, sibel
AU  - Ergün, Dilek
AU  - bahadir, ayse
AU  - düger, mustafa
AU  - ozdemir, fatma
AU  - hocanlı, iclal
AU  - cicek, tugba
AU  - Çetin, Nazlı
AU  - SALIK, BİLGE
AU  - OZCELIK, Neslihan
AU  - Kavas, Murat
AU  - KİLİC, TALAT
DO  - 10.4274/balkanmedj.galenos.2021.2021-10-19
PY  - 2022
JO  - Balkan Medical Journal
VL  - 39
IS  - 2
SN  - 2146-3123
SP  - 148
EP  - 152
DB  - TRDizin
UR  - http://search/yayin/detay/1133635
ER  -