Yıl: 2022 Cilt: 28 Sayı: 5 Sayfa Aralığı: 621 - 625 Metin Dili: İngilizce DOI: 10.9775/kvfd.2022.27807 İndeks Tarihi: 22-10-2022

A Comparison of the Efficacy of Selamectin and Fluralaner in the Treatment of the Canaries Infected with Dermanyssus gallinae

Öz:
Dermanyssus gallinae is a hematophagous ectoparasite responsible for anaemia, weight loss, itching, dermatitis, and also decreased egg production in many domestic and wild bird species. The use of various synthetic acaricides such as avermectin and isoxazoline group is common in its treatment. This study aimed to compare the efficacy of Selamectin and Fluralaner on canaries during D. gallinae infestations. In the study, all canaries before treatment constituted the control group. Two groups of canaries were included in the study (n:40): Selamectin was applied to the first group (n:20) and Fluralaner to the second group (n:20). Selamectin was applied topically and infrascapularly at a 20 mg/kg dose, while Fluralaner was administered orally by a dose of 0.5 mg/kg. Parasite load was evaluated before and after treatment. With regard to the reduction in the mean number of red mites, the treatment successes of Selamectin and Fluralaner were evaluated as percentages of the efficacy. The percentage of efficacy of Selamectin and Fluralaner treatments were 80.0%, and 90.90%, respectively. We conclude that both drugs provide effective treatment in the treatment of D. gallinae infestation in canaries, nevertheless short-term clinical efficacy of Fluralaner was superior to Selamectin.
Anahtar Kelime:

Dermanyssus gallinae İle Enfekte Kanaryaların Tedavisinde Selamektin ve Fluralaner Etkinliğinin Karşılaştırılması

Öz:
Dermanyssus gallinae evcil kuş türlerinde ve yabani kuş türlerinde görülen anemi, kilo kaybı, kaşıntı ve dermatite yol açan ayrıca yumurta üretiminin azalmasına neden olan hematofagöz bir ektoparazit türdür. D. gallinae tedavisinde avermektin ve izoksazolin grubu gibi çeşitli sentetik akarisitlerin kullanımı oldukça yaygındır. Bu çalışma, kanaryalarda D. gallinae enfestasyonlarının tedavisi amacıyla kullanılan Selamektin ve Fluralaner’in etkinliğini karşılaştırmayı amaçladı. Çalışmada tedavi öncesi tüm kanaryalar kontrol grubunu oluşturdu. Çalışmada yer alan kanaryalar (n:40) iki farklı gruba ayrıldı: birinci gruptaki kanaryalara (n:20) Selamektin tedavisi ve ikinci gruptaki kanaryalara (n:20) ise Fluralaner tedavisi uygulandı. Selamektin tedavisi lokal olarak, infraskapular bölgeye 20 mg/kg dozda uygulanırken, Fluralaner tedavisi ise 0.5 mg/kg dozda oral olarak uygulandı. Parazit yükü tedavi öncesinde ve tedavi sonrasında değerlendirildi. Ortalama kırmızı akar sayısındaki azalmaya bağlı olarak Selamektin ve Fluralaner’in tedavi başarıları etkinlik yüzdesi hesaplanarak değerlendirildi. Selamektin tedavisindeki etkinlik yüzdesi %80.0 iken Fluralaner tedavisindeki etkinlik yüzdesi ise %90.90 olarak tespit edildi. Çalışma sonucunda kanaryalarda D. gallinae enfestasyonlarının tedavisinde uygulanan hem Selamaktin hem de Fluralaner’in etkili tedavi sağladığı tespit edildi. Bu çalışmada tedavi edilen kanaryaların kısa süreli klinik etkinliği değerlendirildiğinde ise Fluralaner ile tedavinin etkinlik yüzdesinin Selamektin ile tedavinin etkinlik yüzdesine göre daha yüksek olduğu gözlemlendi.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Boseret G, Losson B, Mainil JG, Thiry E, Saegerman C: Zoonoses in pet birds: Review and perspectives. Vet Res, 44 (1): 1-17, 2013. DOI: 10.1186/1297-9716-44-36
  • 2. Orton DI, Warren LJ, Wilkinson JD: Avian mite dermatitis. Clin Exp Dermatol, 25 (2): 129-131, 2000. DOI: 10.1046/j.1365-2230.2000.00594.x
  • 3. Bartley K, Chen W, Lloyd Mills RI, Nunn F, Price DRG, Rombauts S, Van de Peer Y, Roy L, Nisbet AJ, Burgess STG: Transcriptomic analysis of the poultry red mite, Dermanyssus gallinae, across all stages of the lifecycle. BMC Genom, 22 (1): 1-22, 2021. DOI: 10.1186/s12864-021-07547-9
  • 4. Mul M, Van Niekerk T, Chirico J, Maurer V, Kilpinen O, Sparagano O, Thind B, Zoons J, Moore D, Bell B, Gjevre AG, Chauve C: Control methods for Dermanyssus gallinae in systems for laying hens: Results of an international seminar. Worlds Poult Sci J, 65 (4): 589-600, 2009. DOI: 10.1017/S0043933909000403
  • 5. Schicht S, Qi W, Poveda L, Strube C: The predicted secretome and transmembranome of the poultry red mite Dermanyssus gallinae. Parasit Vectors, 6 (1): 1-12, 2013. DOI: 10.1186/1756-3305-6-259
  • 6. Decru E, Mul M, Nisbet AJ, Vargas Navarro AH, Chiron G, Walton J, Norton T, Roy L, Sleeckx N: Possibilities for IPM Strategies in European laying hen farms for improved control of the Poultry Red Mite (Dermanyssus gallinae): Details and state of affairs. Front Vet Sci, 7:874, 2020. DOI: 10.3389/ fvets.2020.565866
  • 7. Oh SI, Do YJ, Kim E, Yi SW, Yoo JG: Prevalence of poultry red mite (Dermanyssus gallinae) in Korean layer farms and the presence of avian pathogens in the mite. Exp Appl Acarol, 81, 223-238, 2020. DOI: 10.1007/ s10493-020-00502-5
  • 8. Circella E, Pugliese N, Todisco G, Cafiero MA, Sparagano OAE, Camarda A: Chlamydia psittaci infection in canaries heavily infested by Dermanyssus gallinae. Exp Appl Acarol, 55 (4): 329-338, 2011. DOI: 10.1007/ s10493-011-9478-9
  • 9. Sparagano OAE, George DR, Harrington DWJ, Giangaspero A: Significance and control of the poultry red mite, Dermanyssus gallinae. Annu Rev Entomol, 59, 447-466, 2014. DOI: 10.1146/annurev-ento- 011613- 162101
  • 10. DiGeronimo M: Therapeutic review: Selamectin. J Exot Pet Med, 25, 80-83, 2016. DOI: 10.1053/j.jepm.2015.11.001
  • 11. Bishop BF, Bruce CI, Evans NA, Goudie AC, Gration KAF, Gibson SP, Pacey MS, Perry DA, Walshe NDA, Witty MJ: Selamectin: A novel broad- spectrum endectocide for dogs and cats. Vet Parasitol, 91 (3-4): 163-176, 2000. DOI: 10.1016/S0304-4017(00)00289-2
  • 12. Gassel M, Wolf C, Noack S, Williams H, Ilg T: The novel isoxazoline ectoparasiticide fluralaner: Selective inhibition of arthropod gamma- aminobutyric acid- and L- glutamate-gated chloride channels and insecticidal/ acaricidal activity. Insect Biochem Mol Biol, 45, 111-124, 2014. DOI: 10.1016/j.ibmb.2013.11.009
  • 13. Asahi M, Kobayashi M, Matsui H, Nakahira K: Differential mechanisms of action of the novel γ aminobutyric acid receptor antagonist ectoparasiticides fluralaner (A1443) and fipronil. Pest Manag Sci, 71 (1): 91- 95, 2015. DOI: 10.1002/ps.3768
  • 14. Ozoe Y, Asahi M, Ozoe F, Nakahira K, Mita T: The antiparasitic isoxazoline A1443 is a potent blocker of insect ligand-gated chloride channels. Biochem Biophys Res Commun, 391 (1): 744-749, 2010. DOI: 10.1016/j.bbrc.2009.11.131
  • 15. Petersen I, Johannhörster K, Pagot E, Escribano D, Zschiesche E, Thomas E: Assessment of fluralaner as a treatment in controlling Dermanyssus gallinae infestation on commercial layer farms and the potential for resulting benefits of improved bird welfare and productivity. Parasit Vectors, 14 (1):181, 2021. DOI: 10.1186/s13071-021-04685-7
  • 16. Roy L, Chauve CM: Historical review of the genus Dermanyssus Duges, 1834 (Acari: Mesostigmata: Dermanyssidae). Parasite, 14, 87-100, 2007. DOI: 10.1051/parasite/2007142087
  • 17. Davidova R, Vasilev V, Arnaudov V, Boycheva M: Distribution of Dermanyssus gallinae (Mesostigmata: Dermanyssidae) in nests of passerine species. Ann Agri Bio Res, 26 (1): 64-69, 2021.
  • 18. Rosen S, Yeruham I, Braverman Y: Dermatitis in humans associated with the mites Pyemotes tritici, Dermanyssus gallinae, Ornithonyssus bacoti and Androlaelaps casalis in Israel. Med Vet Entomol, 16 (4): 442-444, 2002. DOI: 10.1046/j.1365-2915.2002.00386.x
  • 19. Todisco G, Paoletti B, Giammarino A, Manera M, Sparagano OAE, Iorio R, Giannella B, Robbe D: Comparing therapeutic efficacy between ivermectin, selamectin, and moxidectin in canaries during natural infection with Dermanyssus gallinae. Ann N Y Acad Sci, 1149 (1): 365-367, 2008. DOI: 10.1196/annals.1428.003
  • 20. Sarasola P, Jernigan AD, Walker DK, Castledine J, Smith DG, Rowan TG: Pharmacokinetics of selamectin following intravenous, oral and topical administration in cats and dogs. J Vet Pharmacol Ther, 25 (4): 265-272, 2002. DOI: 10.1046/j.1365-2885.2002.00415.x
  • 21. Hahn A, D’Agostino J, Cole G, Kukanich B: Pharmacokinetics of selamectin in helmeted guineafowl (Numida meleagris) after topical administration. J Zoo Wildl Med, 45 (1): 176-178, 2014. DOI: 10.1638/2013-0112R.1
  • 22. Taenzler J, Wengenmayer C, Williams H, Fourie J, Zschiesche E, Roepke RK, Heckeroth AR: Onset of activity of fluralaner (BRAVECTO) against Ctenocephalides felis on dogs. Parasit Vectors, 7 (1): 1-4, 2014. DOI: 10.1186/s13071-014-0567-6
  • 23. Williams H, Young DR, Qureshi T, Zoller H, Heckeroth AR: Fluralaner, a novel isoxazoline, prevents flea (Ctenocephalides felis) reproduction in vitro and in a simulated home environment. Parasit Vectors, 7 (1): 1-6, 2014. DOI: 10.1186/1756-3305-7-275
  • 24. Taenzler J, de Vos C, Roepke RK, Frénais R, Heckeroth AR: Efficacy of fluralaner against Otodectes cynotis infestations in dogs and cats. Parasit Vectors, 10:30, 2017. DOI: 10.1186/s13071-016-1954-y
  • 25. Heckeroth AR, Zoller H, Flochlay-Sigognault A, Huyghe B: Use of isoxazoline derivatives for the treatment or prevention of arthropod infestations in poultry. Patent WO. 2020.
  • 26. Brauneis MD, Zoller H, Williams H, Zschiesche E, Heckeroth AR: The acaricidal speed of kill of orally administered fluralaner against poultry red mites (Dermanyssus gallinae) on laying hens and its impact on mite reproduction. Parasit Vectors, 10 (1): 1-8, 2017. DOI: 10.1186/s13071-017- 2534-5
  • 27. Batan IW, Ananda MK, Sembiring MSB, Sianipar DHA, Sunusi S, Noviarini DART, Hadi UK: Detection of Falculifer sp. mites in eagles in rehabilitation cage of Bali Wildlife Rescue Center. IOP Conf Ser Earth Environ Sci, 590 (1): 1-5, 2020. DOI: 10.1088/1755-1315/590/1/012012
  • 28. Gozalo AS, Schwiebert RS, Lawson GW: Mortality associated with fenbendazole administration in pigeons (Columba livia). J Am Assoc Lab Anim Sci, 45 (6): 63-66, 2006. PubMed PMID: 17089995
APA ESİN Ç, Ağan U, Raouf S (2022). A Comparison of the Efficacy of Selamectin and Fluralaner in the Treatment of the Canaries Infected with Dermanyssus gallinae. , 621 - 625. 10.9775/kvfd.2022.27807
Chicago ESİN ÇAĞATAY,Ağan Umut Burak,Raouf Saba A Comparison of the Efficacy of Selamectin and Fluralaner in the Treatment of the Canaries Infected with Dermanyssus gallinae. (2022): 621 - 625. 10.9775/kvfd.2022.27807
MLA ESİN ÇAĞATAY,Ağan Umut Burak,Raouf Saba A Comparison of the Efficacy of Selamectin and Fluralaner in the Treatment of the Canaries Infected with Dermanyssus gallinae. , 2022, ss.621 - 625. 10.9775/kvfd.2022.27807
AMA ESİN Ç,Ağan U,Raouf S A Comparison of the Efficacy of Selamectin and Fluralaner in the Treatment of the Canaries Infected with Dermanyssus gallinae. . 2022; 621 - 625. 10.9775/kvfd.2022.27807
Vancouver ESİN Ç,Ağan U,Raouf S A Comparison of the Efficacy of Selamectin and Fluralaner in the Treatment of the Canaries Infected with Dermanyssus gallinae. . 2022; 621 - 625. 10.9775/kvfd.2022.27807
IEEE ESİN Ç,Ağan U,Raouf S "A Comparison of the Efficacy of Selamectin and Fluralaner in the Treatment of the Canaries Infected with Dermanyssus gallinae." , ss.621 - 625, 2022. 10.9775/kvfd.2022.27807
ISNAD ESİN, ÇAĞATAY vd. "A Comparison of the Efficacy of Selamectin and Fluralaner in the Treatment of the Canaries Infected with Dermanyssus gallinae". (2022), 621-625. https://doi.org/10.9775/kvfd.2022.27807
APA ESİN Ç, Ağan U, Raouf S (2022). A Comparison of the Efficacy of Selamectin and Fluralaner in the Treatment of the Canaries Infected with Dermanyssus gallinae. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 28(5), 621 - 625. 10.9775/kvfd.2022.27807
Chicago ESİN ÇAĞATAY,Ağan Umut Burak,Raouf Saba A Comparison of the Efficacy of Selamectin and Fluralaner in the Treatment of the Canaries Infected with Dermanyssus gallinae. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 28, no.5 (2022): 621 - 625. 10.9775/kvfd.2022.27807
MLA ESİN ÇAĞATAY,Ağan Umut Burak,Raouf Saba A Comparison of the Efficacy of Selamectin and Fluralaner in the Treatment of the Canaries Infected with Dermanyssus gallinae. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, vol.28, no.5, 2022, ss.621 - 625. 10.9775/kvfd.2022.27807
AMA ESİN Ç,Ağan U,Raouf S A Comparison of the Efficacy of Selamectin and Fluralaner in the Treatment of the Canaries Infected with Dermanyssus gallinae. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2022; 28(5): 621 - 625. 10.9775/kvfd.2022.27807
Vancouver ESİN Ç,Ağan U,Raouf S A Comparison of the Efficacy of Selamectin and Fluralaner in the Treatment of the Canaries Infected with Dermanyssus gallinae. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2022; 28(5): 621 - 625. 10.9775/kvfd.2022.27807
IEEE ESİN Ç,Ağan U,Raouf S "A Comparison of the Efficacy of Selamectin and Fluralaner in the Treatment of the Canaries Infected with Dermanyssus gallinae." Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 28, ss.621 - 625, 2022. 10.9775/kvfd.2022.27807
ISNAD ESİN, ÇAĞATAY vd. "A Comparison of the Efficacy of Selamectin and Fluralaner in the Treatment of the Canaries Infected with Dermanyssus gallinae". Kafkas Üniversitesi Veteriner Fakültesi Dergisi 28/5 (2022), 621-625. https://doi.org/10.9775/kvfd.2022.27807