A Meta-Analysis of the Associations Between Prolactin (PRL) Gene Polymorphism and Milk Production Traits in Cattle

Ekinci, kübra; BİLGİN, Ebru; Özdemir, Memiş; SAYGILI, ESRANUR; Motmain, Zekrullah

doi:10.9775/kvfd.2022.27857

A Meta-Analysis of the Associations Between Prolactin (PRL) Gene Polymorphism and Milk Production Traits in Cattle

Zekrullah Motmain, (Atatürk Üniversitesi Ziraat Fakültesi Zootekni Anabilim Dalı, TR25240 Erzurum - TÜRKİYE)

Memiş ÖZDEMİR, (Atatürk Üniversitesi Ziraat Fakültesi Zootekni Anabilim Dalı, TR25240 Erzurum - TÜRKİYE)

Kübra EKİNCİ, (Atatürk Üniversitesi Ziraat Fakültesi Zootekni Anabilim Dalı, TR25240 Erzurum - TÜRKİYE)

Esranur SAYGILI, (Atatürk Üniversitesi Ziraat Fakültesi Zootekni Anabilim Dalı, TR25240 Erzurum - TÜRKİYE)

Ebru BİLGİN (Atatürk Üniversitesi Ziraat Fakültesi Zootekni Anabilim Dalı, TR25240 Erzurum - TÜRKİYE)

Kafkas Üniversitesi Veteriner Fakültesi Dergisi

8 0

Yıl: 2022 Cilt: 28 Sayı: 5 Sayfa Aralığı: 627 - 631 Metin Dili: İngilizce DOI: 10.9775/kvfd.2022.27857 İndeks Tarihi: 22-10-2022

A Meta-Analysis of the Associations Between Prolactin (PRL) Gene Polymorphism and Milk Production Traits in Cattle

Öz:

The meta-analysis method is used to combine results from many independent studies conducted in a different region or area on a specific subject qualitatively and quantitatively and achieve a consensus. The current meta-analysis was conducted to investigate the association between prolactin gene polymorphism and milk production traits in dairy cattle. The data were collected between 2002 and 2021, and a total of 26 published studies were included in this study. The standardized mean difference (SMD) between genotypes was obtained for statistical evaluation, and to this end, the genetic models (dominant; AA + AB and BB, recessive; AB + BB with AA, co-dominant; AA, BB and AB genotypes) were compared with each other. In the analysis results, cattle with the AB versus BB genotype (SMD=0.289, 95% CI 0.005, 0.573) were found to have a statistically significant higher protein yield in comparison with the AA versus AB and AA versus BB genotypes. The relationships between prolactin gene polymorphism and milk yield, fat yield, fat content, and protein content traits were not found to be statistically significant.

Anahtar Kelime:

Sığırlarda Prolaktin (PRL) Geni Polimorfizmi İle Süt Verim Özellikleri Arasındaki İlişkilerin Meta Analizi

Öz:

Meta Analizi, belirli bir konu üzerinde farklı bölge veya alanlarda yapılmış birçok bağımsız çalışmanın sonuçlarını niteliksel ve niceliksel olarak birleştirmek ve fikir birliğine varmak amacıyla kullanılan bir yöntemdir. Meta-analizi, süt sığırlarında prolaktin geni polimorfizmi ile süt verim özellikleri arasındaki ilişkiyi araştırmak için uygulanmıştır. Veriler 2002-2021 yılları arasında yayınlanmış 26 çalışma analizlere dahil edildi. İstatistiksel değerlendirme için genotipler arasında standartlaştırılmış ortalama farkı (SMD) elde edildi ve bu amaçla genetik model: baskın; AA + AB ile BB, çekinik; AA ile AB + BB, eş baskın; AA, BB ve AB genotipleri birbirleriyle karşılaştırıldı. Analiz sonuçları, AB ile BB genotipine sahip sığırların (SMD=0.289, %95 CI 0.005, 0.573), AA ile AB ve AA ile BB genotipli sığırlara kıyasla istatistiksel olarak anlamlı bir yüksek protein verimine sahip olduklarını göstermiştir. Prolaktin geni polimorfizmi ile incelenen diğer süt verimi, yağ verimi, yağ içeriği ve protein içeriği özellikleri arasındaki ilişkiler istatistiksel olarak anlamlı değildi.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Ozdemir M, Kapuzlu S, Topal M, Bilgin OC: Relationships between milk protein polymorphisms and production traits in cattle: A systematic review and meta-analysis. Arch Anim Breed, 61, 197-206, 2018. DOI: 10.5194/aab- 61-197-2018
2. Ozdemir M, Esenbuga N: Associations among beta-lactoglobulın genotypes and some production traıts in sheep: A systematic review and meta-analysis. J Anim Plant Sci, 5, 1092-1097, 2020. DOI: 10.36899/ japs.2020.5.0124
3. Unal EO, Kepenek ES, Dinc HO, Sonmez F, Togan IZ, Soysal MI: Growth hormone (GH), prolactin (PRL), and diacylglycerol acyltransferase (DGAT1) gene polymorphisms in Turkish native cattle breeds. Turk J Zool, 39, 1409-1409, 2014. DOI: 10.3906/zoo-1409-9
4. Ghasemi N, Rahmani MZ, Rahimi G, Hafezian SH: Associations between prolactin gene polymorphism and milk production in montebeliard cows. Int J Gen Mol Biol, 1 (3): 48-51, 2009.
5. Alfonso E, Rojas R, Herrera JG, Ortega ME, Lemus C, Ruiz J, Pinto R, Gomez H: Polymorphism of the prolactin gene (Prl) and its relationship with milk production in American Swiss cattle. Afr J Biotechnol, 11, 7338- 7343, 2012.
6. Bangar YC, Patil CS, Magotra A, Yadav AS: Meta-analysis of gene Research Article631MOTMAIN,ÖZDEM REK NC ,SAYGILI,B LG N polymorphism of beta-lactoglobulin gene in indian dairy cows. Biochem Genet, 60 (3): 1039-1048, 2022. DOI: 10.1007/s10528-021-10153-9
7. Alipanah M, Kalashnikova L, Rodionov G: Association of prolactin gene variants with milk production traits in Russian Red Pied cattle. Iran J Biotechnol, 5, 158-161, 2007.
8. Brym P, Kaminski S, Wojcik E: Nucleotide sequence polymorphism within exon 4 of the bovine prolactin gene and its associations with milk performance traits. J Appl Genet, 4, 179-185, 2005.
9. Uddin MR, Babar ME, Nadeem A, Hussain T, Ahmad S, Munir S, Mehboob R, Ahmad FJ: Genetic analysis of prolactin gene in Pakistani cattle. Mol Biol Rep, 40, 5685-5689, 2013. DOI: 10.1007/s11033-013-2670-8
10. Lu A, Hu X, Chen H, Jiang J, Zhang C, Xu H, Gao X: Single nucleotide polymorphisms in bovine PRL gene and their associations with milk production traits in Chinese Holsteins. Mol Biol Rep, 37, 547-551, 2010. DOI: 10.1007/s11033-009-9762-5
11. Patel JB, Chauhan JB: Polymorphism of the prolactin gene and its relationship with milk production in Gir and Kankrej. J Nat Sci Biol Med, 8 (2): 167-170, 2017. DOI: 10.4103/jnsbm.JNSBM_303_16
12. Ozdemir M, Sonmez Z, Aksakal V: Associations between PRL/RsaI polymorphism and some performance traits in Holstein cattle reared under organic condition. J Anim Plant Sci, 31 (3): 900-905, 2021. DOI: 10.36899/ JAPS.2021.3.0279
13. Mahajan V, Parmar SNS, Thakur MS: Association of prolactin gene variants with milk production traits in Malvi and Nimari cattle. J Anim Res, 2 (1): 17-23, 2012.
14. Akyüz B, Arslan K, Bayram D, İşcan KM: Allelic frequency of kappa- casein, growth hormone and prolactin gene in Holstein, Brown Swiss and Simmental cattle breeds in Turkey. Kafkas Univ Vet Fak Derg, 19 (3): 439- 444, 2013. DOI: 10.9775/kvfd.2012.7985
15. Cohen J: Statistical Power Analysis for the Behavioral Sciences. Second ed., Lawrence Erlbaum Associates, 1988.
16. Akçay A, Daldaban F, Çelik E, Arslan K, Akyüz B: Meta analysis of allele and genotype frequency of growth hormone (bGH) gene AluI polymorphism, which is effective on milk yield in Holstein cattle. Kafkas Univ Vet Fak Derg, 26 (5): 687-695, 2020. DOI: 10.9775/kvfd.2020.24256
17. Arserim BN, Keskin O: Veteriner epidemiyoloji’de sistematik derleme ve meta-analizi. Dicle Üniv Vet Fak Derg, 2 (1): 37-39, 2012.
18. Chrenek P, Huba J, Vasicek D: The relation between genetic polymorphism markers and milk yield in Brown Swiss cattle imported to Slovakia. Asian-Australas J Anim Sci, 16 (10): 1397-1401, 2003. DOI: 10.5713/ajas.2003.1397
19. Dybus A, Grzesiak W, Kamieniecki H, Szatkowsk I, Sobek Z, Blaszczyk P, Czerniawska PE, Zych S, Muszynska M: Association of genetic variants of bovine prolactin with milk production traits of Black-and-White and Jersey cattle. Arch Tierzucht, 48, 149-156, 2005. DOI: 10.5194/aab-48-149- 2005
20. Sacravarty G, Vadodaria VP, Joshi CG, Brahmkshtri BP, Shah RR, Solanki JV: Prolactin gene polymorphism and its association with economic traits in Kankrej cattle. Indian J Dairy Sci, 61 (4): 273-276, 2008.
21. Kalashnikova LA, Khabibrakhmanova YA, Tinaev A: Effect of polymorphism of milk protein and hormone genes on milk productivity of Black Pied cows. Russ Agri Sci, 35 (3): 192-195, 2009. DOI: 10.3103/ S1068367409030185
22. Rincon JC, Herrera L, Echeverri JJ: Effect of two single nucleotide polymorphisms on milk yield and composition. Genet Mol Res, 12 (2): 995- 1004, 2013. DOI:10.4238/2013.April.2.15
23. Arslan K, Taheri S, Şener EF, Akyüz B, Akçay A, Özkul Y, Işcan KM: Investigation of the promoter polymorphisms of the growth hormone (GH1), growth hormone receptor (GHR), insulin-like growth factor (IGF-I), and prolactin (PRL) genes and the correlation between gene expression and milk yields in Holstein cattle raised in Central Anatolia. Turk J Vet Anim Sci, 40, 609-615, 2016. DOI: 10.3906/vet-1510-66
24. Akkaya M, Akyuz B: Investigation of the Relationship between GHRH and PRL Genes Polymorphsims and Milk Yield in Holstein Cattle Breed Reared in Turkey. KSU J Agric Nat, 22 (5): 763-771, 2019. DOI: 10.18016/ ksutarimdoga.vi.530786
25. Cepreepha XT: Polymorphism of CSN3, BLG, PRL Genes and their Relationship with Milk Production and Quality In Cattle. Agrobiotechnologies of The Russian Academy of Sciences, PhD Thesis, Novosibirsk, 2021.
26. Boleckova J, Matejickova J, Stipkova, M. Kyselova J, Barton L: The association of five polymorphisms with milk production traits in Czech Fleckvieh cattle. Czech J Anim Sci, 57, 45-53, 2012. DOI: 10.17221/5131-CJAS
27. Dong CH, Song XM, Zhang L, Jiang JF, Zhou JP, Jiang YQ: New insights into the prolactin-RsaI (PRL-RsaI) locus in Chinese Holstein cows and its effect on milk performance traits. Genet Mol Res, 12, 5766-5773, 2013. DOI: 10.4238/2013.November.22.3
28. Goryacheva TS, Goncharenko GM: Polymorphism in κ-casein and prolactin genes and their influence on dairy productivity of cows of the black-and-white breed. Agricultural Biology, 4, 51-54, 201

APA	Motmain Z, Özdemir M, Ekinci k, SAYGILI E, BİLGİN E (2022). A Meta-Analysis of the Associations Between Prolactin (PRL) Gene Polymorphism and Milk Production Traits in Cattle. , 627 - 631. 10.9775/kvfd.2022.27857
Chicago	Motmain Zekrullah,Özdemir Memiş,Ekinci kübra,SAYGILI ESRANUR,BİLGİN Ebru A Meta-Analysis of the Associations Between Prolactin (PRL) Gene Polymorphism and Milk Production Traits in Cattle. (2022): 627 - 631. 10.9775/kvfd.2022.27857
MLA	Motmain Zekrullah,Özdemir Memiş,Ekinci kübra,SAYGILI ESRANUR,BİLGİN Ebru A Meta-Analysis of the Associations Between Prolactin (PRL) Gene Polymorphism and Milk Production Traits in Cattle. , 2022, ss.627 - 631. 10.9775/kvfd.2022.27857
AMA	Motmain Z,Özdemir M,Ekinci k,SAYGILI E,BİLGİN E A Meta-Analysis of the Associations Between Prolactin (PRL) Gene Polymorphism and Milk Production Traits in Cattle. . 2022; 627 - 631. 10.9775/kvfd.2022.27857
Vancouver	Motmain Z,Özdemir M,Ekinci k,SAYGILI E,BİLGİN E A Meta-Analysis of the Associations Between Prolactin (PRL) Gene Polymorphism and Milk Production Traits in Cattle. . 2022; 627 - 631. 10.9775/kvfd.2022.27857
IEEE	Motmain Z,Özdemir M,Ekinci k,SAYGILI E,BİLGİN E "A Meta-Analysis of the Associations Between Prolactin (PRL) Gene Polymorphism and Milk Production Traits in Cattle." , ss.627 - 631, 2022. 10.9775/kvfd.2022.27857
ISNAD	Motmain, Zekrullah vd. "A Meta-Analysis of the Associations Between Prolactin (PRL) Gene Polymorphism and Milk Production Traits in Cattle". (2022), 627-631. https://doi.org/10.9775/kvfd.2022.27857

APA	Motmain Z, Özdemir M, Ekinci k, SAYGILI E, BİLGİN E (2022). A Meta-Analysis of the Associations Between Prolactin (PRL) Gene Polymorphism and Milk Production Traits in Cattle. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 28(5), 627 - 631. 10.9775/kvfd.2022.27857
Chicago	Motmain Zekrullah,Özdemir Memiş,Ekinci kübra,SAYGILI ESRANUR,BİLGİN Ebru A Meta-Analysis of the Associations Between Prolactin (PRL) Gene Polymorphism and Milk Production Traits in Cattle. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 28, no.5 (2022): 627 - 631. 10.9775/kvfd.2022.27857
MLA	Motmain Zekrullah,Özdemir Memiş,Ekinci kübra,SAYGILI ESRANUR,BİLGİN Ebru A Meta-Analysis of the Associations Between Prolactin (PRL) Gene Polymorphism and Milk Production Traits in Cattle. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, vol.28, no.5, 2022, ss.627 - 631. 10.9775/kvfd.2022.27857
AMA	Motmain Z,Özdemir M,Ekinci k,SAYGILI E,BİLGİN E A Meta-Analysis of the Associations Between Prolactin (PRL) Gene Polymorphism and Milk Production Traits in Cattle. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2022; 28(5): 627 - 631. 10.9775/kvfd.2022.27857
Vancouver	Motmain Z,Özdemir M,Ekinci k,SAYGILI E,BİLGİN E A Meta-Analysis of the Associations Between Prolactin (PRL) Gene Polymorphism and Milk Production Traits in Cattle. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2022; 28(5): 627 - 631. 10.9775/kvfd.2022.27857
IEEE	Motmain Z,Özdemir M,Ekinci k,SAYGILI E,BİLGİN E "A Meta-Analysis of the Associations Between Prolactin (PRL) Gene Polymorphism and Milk Production Traits in Cattle." Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 28, ss.627 - 631, 2022. 10.9775/kvfd.2022.27857
ISNAD	Motmain, Zekrullah vd. "A Meta-Analysis of the Associations Between Prolactin (PRL) Gene Polymorphism and Milk Production Traits in Cattle". Kafkas Üniversitesi Veteriner Fakültesi Dergisi 28/5 (2022), 627-631. https://doi.org/10.9775/kvfd.2022.27857