TY  - JOUR
TI  - Efficacy and Safety of Direct-Acting Antivirals in Elderly Patients with Chronic Hepatitis C: A Nationwide Real-Life, Observational, Multicenter Study from Turkey
AB  - Background: The number and proportion of elderly patients living with chronic hepatitis C are expected to increase in the coming years. We aimed to compare the real-world efficacy and safety of direct-acting antiviral treatment in elderly and younger Turkish adults infected with chronic hepatitis C. Methods: In this multicenter prospective study, 2629 eligible chronic hepatitis C patients treated with direct-acting antivirals between April 2017 and December 2019 from 37 Turkish referral centers were divided into 2 age groups: elderly (≥65 years) and younger adults (<65 years) and their safety was compared between 2 groups in evaluable population. Then, by matching the 2 age groups for demographics and pretreatment risk factors for a non-sustained virological response, a total of 1516 patients (758 in each group) and 1244 patients (622 in each group) from the modified evaluable population and per-protocol population were included in the efficacy analysis and the efficacy was compared between age groups. Results: The sustained virological response in the chronic hepatitis C patients was not affected by the age and the presence of cirrhosis both in the modified evaluable population and per-protocol population (P = .879, P = .508 for modified evaluable population and P = .058, P = .788 for per-protocol population, respectively). The results of the per-protocol analysis revealed that male gender, patients who had a prior history of hepatocellular carcinoma, patients infected with non-genotype 1 hepatitis C virus, and patients treated with sofosbuvir + ribavirin had a significantly lower sustained virological response 12 rates (P < .001, P = .047, P = .013, and P = .025, respectively). Conclusion: Direct-acting antivirals can be safely used to treat Turkish elderly chronic hepatitis C patients with similar favorable efficacy and safety as that in younger adults.
AU  - İNAN, DİLARA
AU  - GÜNER, RAHMET
AU  - Tosun, Selma
AU  - Sener, Alper
AU  - komur, suheyla
AU  - Barut, Sener
AU  - zerdali, esra
AU  - Baykam, Nurcan
AU  - Kaya, Sibel
AU  - Bal, Tayibe
AU  - Yörük, Gülşen
AU  - KARABAY, OĞUZ
AU  - Gunduz, Alper
AU  - KARAALİ, Rıdvan
AU  - Şenateş, Ebubekir
AU  - Celebi, Guven
AU  - Akıncı, Esragül
AU  - Sunnetcioglu, Mahmut
AU  - Oztoprak, Nefise
AU  - Ince, Nevin
AU  - User, Ulku
AU  - Erben, Nurettin
AU  - AKBULUT, AYHAN
AU  - YILDIZ, ILKNUR ESEN
AU  - Sarıgül, Figen
AU  - Türker, Kamuran
AU  - çabalak, mehmet
AU  - NAMIDURU, Mustafa
AU  - ONLEN, YÜSÜF
AU  - KARSEN, HASAN
AU  - Batirel, Ayse
AU  - Yamazhan, Tansu
AU  - köse, şükran
AU  - Duygu, Fazilet
AU  - Can, Güray
AU  - Koksal, Iftihar
AU  - Didem sarı, Nagehan
AU  - kumbasar karaosmanoglu, hayat
AU  - hizel, kenan
AU  - GÜL, Hanefi Cem
AU  - Gunal, Ozgur
AU  - Tabak, Fehmi
AU  - Kurtaran, Behice
AU  - Esen, Şaban
AU  - SIRMATEL, FATMA
DO  - 10.5152/tjg.2022.21271
PY  - 2022
JO  - Turkish Journal of Gastroenterology
VL  - 33
IS  - 10
SN  - 1300-4948
SP  - 862
EP  - 873
DB  - TRDizin
UR  - http://search/yayin/detay/1134402
ER  -