BIOLOGICAL ACTIVITY EVALUATION OF THREE Hypericum L. SPECIES

Cevik, Ozge; Ozpinar, Necati; Tekin, Mehmet; Ataş, Mehmet; Ozpinar, Hulya; ERUYGUR, Nuraniye

doi:10.23902/trkjnat.1043241

BIOLOGICAL ACTIVITY EVALUATION OF THREE Hypericum L. SPECIES

Nuraniye ERUYGUR, (Selçuk Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Konya, Türkiye)

Necati ÖZPINAR, (Mustafa Kemal Üniversitesi, Sağlık Bilimleri Fakültesi, Acil Yardım ve Afet Yönetimi Bölümü, Hatay, Türkiye)

Hülya ÖZPINAR, (Sivas Cumhuriyet Üniversitesi, Eczacılık Fakültesi, Farmasötik Botanik Anabilim Dalı, Sivas, Türkiye)

Mehmet ATAŞ, (Sivas Cumhuriyet Üniversitesi, Eczacılık Fakültesi, Farmasötik Mikrobiyoloji Anabilim Dalı, Sivas, Türkiye)

Mehmet TEKİN, (Trakya Üniversitesi, Eczacılık Fakültesi, Farmasötik Botanik Anabilim Dalı, Edirne, Türkiye)

Özge ÇEVİK (Adnan Menderes Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Aydın, Türkiye)

Trakya University Journal of Natural Sciences

2 0

Yıl: 2022 Cilt: 23 Sayı: 2 Sayfa Aralığı: 125 - 134 Metin Dili: İngilizce DOI: 10.23902/trkjnat.1043241 İndeks Tarihi: 25-10-2022

BIOLOGICAL ACTIVITY EVALUATION OF THREE Hypericum L. SPECIES

Öz:

This study was performed in order to evaluate in vitro antioxidant, anti-Trichomonas vaginalis, antimicrobial and cytotoxic activities of methanol extracts of aerial parts of Hypericum perforatum L., H. thymbrifolium Boiss. & Noë and H. thymopsis Boiss. The antioxidant activity of methanol extracts was tested with 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging and iron chelating assays. The total phenol and flavonoid contents were also determined spectrophotometrically. Cytotoxicity and apoptosis were evaluated on MCF-7 breast cancer and PC3 prostate cancer cell line. Antimicrobial activities were evaluated by the microdilution method on the bacterial strains Staphylococcus aureus (ATCC 29213), Enterococcus faecalis (ATCC 29212), Pseudomonas aeruginosa (ATCC 27853) Escherichia coli (ATCC 25922) and the fungal strain Candida albicans (ATCC 10231). All extracts demonstrated cytotoxic activity on PC3 prostat cancer cell line with a concentration dependent manner, while H. thymopsis extract was the most active against cancer cell growth. The obtained results of the present study revealed that the methanol extract of H. perforatum, H. thymbrifolium and H. thymopsis have significant antioxidant and cytotoxic activities. The results provided the basic research data for further phytochemical and biological activity guided investigations on these species for identication and isolation of potential drug active compounds.

Anahtar Kelime: Hypericum perforatum Hypericum thymbrifolium Hypericum thymopsis Antioxidant Anti-Trichomonas Antimicrobial Cytotoxicity

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ERUYGUR N, Ozpinar N, Ozpinar H, Ataş M, Tekin M, Cevik O (2022). BIOLOGICAL ACTIVITY EVALUATION OF THREE Hypericum L. SPECIES. , 125 - 134. 10.23902/trkjnat.1043241
Chicago	ERUYGUR Nuraniye,Ozpinar Necati,Ozpinar Hulya,Ataş Mehmet,Tekin Mehmet,Cevik Ozge BIOLOGICAL ACTIVITY EVALUATION OF THREE Hypericum L. SPECIES. (2022): 125 - 134. 10.23902/trkjnat.1043241
MLA	ERUYGUR Nuraniye,Ozpinar Necati,Ozpinar Hulya,Ataş Mehmet,Tekin Mehmet,Cevik Ozge BIOLOGICAL ACTIVITY EVALUATION OF THREE Hypericum L. SPECIES. , 2022, ss.125 - 134. 10.23902/trkjnat.1043241
AMA	ERUYGUR N,Ozpinar N,Ozpinar H,Ataş M,Tekin M,Cevik O BIOLOGICAL ACTIVITY EVALUATION OF THREE Hypericum L. SPECIES. . 2022; 125 - 134. 10.23902/trkjnat.1043241
Vancouver	ERUYGUR N,Ozpinar N,Ozpinar H,Ataş M,Tekin M,Cevik O BIOLOGICAL ACTIVITY EVALUATION OF THREE Hypericum L. SPECIES. . 2022; 125 - 134. 10.23902/trkjnat.1043241
IEEE	ERUYGUR N,Ozpinar N,Ozpinar H,Ataş M,Tekin M,Cevik O "BIOLOGICAL ACTIVITY EVALUATION OF THREE Hypericum L. SPECIES." , ss.125 - 134, 2022. 10.23902/trkjnat.1043241
ISNAD	ERUYGUR, Nuraniye vd. "BIOLOGICAL ACTIVITY EVALUATION OF THREE Hypericum L. SPECIES". (2022), 125-134. https://doi.org/10.23902/trkjnat.1043241

APA	ERUYGUR N, Ozpinar N, Ozpinar H, Ataş M, Tekin M, Cevik O (2022). BIOLOGICAL ACTIVITY EVALUATION OF THREE Hypericum L. SPECIES. Trakya University Journal of Natural Sciences, 23(2), 125 - 134. 10.23902/trkjnat.1043241
Chicago	ERUYGUR Nuraniye,Ozpinar Necati,Ozpinar Hulya,Ataş Mehmet,Tekin Mehmet,Cevik Ozge BIOLOGICAL ACTIVITY EVALUATION OF THREE Hypericum L. SPECIES. Trakya University Journal of Natural Sciences 23, no.2 (2022): 125 - 134. 10.23902/trkjnat.1043241
MLA	ERUYGUR Nuraniye,Ozpinar Necati,Ozpinar Hulya,Ataş Mehmet,Tekin Mehmet,Cevik Ozge BIOLOGICAL ACTIVITY EVALUATION OF THREE Hypericum L. SPECIES. Trakya University Journal of Natural Sciences, vol.23, no.2, 2022, ss.125 - 134. 10.23902/trkjnat.1043241
AMA	ERUYGUR N,Ozpinar N,Ozpinar H,Ataş M,Tekin M,Cevik O BIOLOGICAL ACTIVITY EVALUATION OF THREE Hypericum L. SPECIES. Trakya University Journal of Natural Sciences. 2022; 23(2): 125 - 134. 10.23902/trkjnat.1043241
Vancouver	ERUYGUR N,Ozpinar N,Ozpinar H,Ataş M,Tekin M,Cevik O BIOLOGICAL ACTIVITY EVALUATION OF THREE Hypericum L. SPECIES. Trakya University Journal of Natural Sciences. 2022; 23(2): 125 - 134. 10.23902/trkjnat.1043241
IEEE	ERUYGUR N,Ozpinar N,Ozpinar H,Ataş M,Tekin M,Cevik O "BIOLOGICAL ACTIVITY EVALUATION OF THREE Hypericum L. SPECIES." Trakya University Journal of Natural Sciences, 23, ss.125 - 134, 2022. 10.23902/trkjnat.1043241
ISNAD	ERUYGUR, Nuraniye vd. "BIOLOGICAL ACTIVITY EVALUATION OF THREE Hypericum L. SPECIES". Trakya University Journal of Natural Sciences 23/2 (2022), 125-134. https://doi.org/10.23902/trkjnat.1043241