TY  - JOUR
TI  - Microbial Transformation of 3,3-Dimethylcyclohexyl methyl ketone and  Antimicrobial Evaluation
AB  - 3,3-Dimethylcyclohexyl methyl ketone (Herbac®) is a fine fragrance compound used in the cosmetic industry. In this study, the biological derivatisation of the substrate 3,3-dimethylcyclohexyl methyl ketone by 18 fungal cultures was  carried out to obtain new derivatives. Among the evaluated, the plant fungus Aspergillus niger ATCC 10549, biotransformed the substrate to the 4-hydroxy derivative in 19% yield. The structure was determined by using NMR and GC-MS methods. In addition, the antimicrobial activity of Herbac® with the metabolite against a panel of pathogenic microbial strains were evaluated using an in vitro microdilution assay. The results showed that the metabolite was relatively more susceptible to the pathogens compared to the substrate.
AU  - Demirci, Fatih
AU  - Baser, Kemal Husnu Can
AU  - kiran, İsmail
AU  - Özşen Batur, Özge
DO  - 10.15671/hjbc.982977
PY  - 2022
JO  - Hacettepe Journal of Biology and Chemistry
VL  - 50
IS  - 3
SN  - 1303-5002
SP  - 263
EP  - 267
DB  - TRDizin
UR  - http://search/yayin/detay/1134721
ER  -