Effect of asymptomatic COVID-19 infection on the placenta in the third trimester of pregnancy: A prospective case-control study
Yıl: 2022 Cilt: 19 Sayı: 3 Sayfa Aralığı: 178 - 186 Metin Dili: İngilizce DOI: 10.4274/tjod.galenos.2022.94984 İndeks Tarihi: 27-10-2022
Effect of asymptomatic COVID-19 infection on the placenta in the third trimester of pregnancy: A prospective case-control study
Öz: Objective: To clarify the effect of asymptomatic coronaviruse disease-2019 (COVID-19) positivity on the placenta in the third trimester of pregnancy. Materials and Methods: This prospective, case-control study included 30 pregnant women diagnosed with asymptomatic COVID-19 between April 30, 2021 and July 20, 2021 who delivered after the 34th gestational week, and a control group of 30 pregnant women without COVID-19, who delivered between April 2021 and July 2021, matched to the study group regarding age, gestational age and body mass index. Outcomes were compared in terms of demographic characteristics, serum blood outcomes, neonatal results, complications and placental histopathological findings. Results: The mean age of the study population was 28.8 years and the mean gestational week was 38.2 weeks. The C-reactive protein levels (38.2 mg/L vs 5.8 mg/L, p=0.001) and ferritin levels (266.4 μg/L and 40.5 μg/L, p=0.001) were significantly higher in the COVID-19-positive pregnant women. The lymphocyte level was significantly higher in the non-COVID-19 pregnant women (p=0.040). Mural hypertrophy was determined at a significantly higher rate in COVID-positive pregnant women (83.3% vs 30.0%, p=0.001). Multivariate regression analysis showed that only COVID-19 positivity increased the presence of mural hypertrophy in pregnant women with asymptomatic COVID-19 (4.716-fold, 95% confidence interval=1.012-22.251). Conclusion: The results of this study demonstrated that asymptomatic COVID-19 had no significant effect on pregnancy and neonatal complications. However, mural hypertrophy in the placenta was found at a significantly higher rate in pregnant women with asymptomatic COVID-19.
Anahtar Kelime: Term gebeliklerde asemptomatik COVID-19’un plasentaya etkisi: Prospektif olgu-kontrol çalışması
Öz: Amaç: Term gebeliklerde asemptomatik koronavirüs hastalığı-2019 (COVID-19) pozitifliğinin gebelik ve plasenta üzerindeki etkisini araştırmak amaçlandı. Gereç ve Yöntemler: Bu prospektif, olgu-kontrol çalışmasına 30 Nisan 2021 ile 20 Temmuz 2021 tarihleri arasında asemptomatik COVID-19 tanısı konan ve 34. gebelik haftasından sonra doğum yapan gebeler ile COVID-19 olmayan 30 gebeden oluşan bir kontrol grubu dahil edilmiştir. Kontrol grubu ile çalışma grubu yaş, gebelik yaşı ve vücut kitle indeksi açısından eşleştirildi. Sonuçlar demografik özellikler, serum kan sonuçları, neonatal sonuçlar, komplikasyonlar ve plasental histopatolojik bulgular açısından karşılaştırıldı. Bulgular: Çalışma popülasyonunun ortalama yaşı 28,8 yıl ve ortalama gebelik haftası 38,2 hafta idi. COVID-19 pozitif gebelerde C-reaktif protein düzeyi (38,2 mg/L vs 5,8 mg/L, p=0,001) ve ferritin düzeyi (266,4 μg/L ve 40,5 μg/L, p=0,001) anlamlı olarak daha yüksekti. COVID-19 olmayan gebe kadınlarda lenfosit düzeyi anlamlı olarak daha yüksekti (p=0,040). Mural hipertrofi, COVID-19 pozitif gebe kadınlarda anlamlı olarak daha yüksek oranda belirlendi (%83,3’e karşı %30,0, p=0,001). Çok değişkenli regresyon analizi ile asemptomatik COVID-19’lu gebe kadınlarda sadece COVID-19 pozitifliğinin mural hipertrofi varlığını anlamlı oranda artırdığı gösterildi (4.716 kat, %95 güven aralığı=1.012-22.251). Sonuç: Bu çalışmanın sonuçları asemptomatik COVID-19’un gebelik ve yenidoğan komplikasyonları üzerinde anlamlı bir etkisinin olmadığını göstermiştir. Bununla birlikte, asemptomatik COVID-19’lu hamile kadınlarda plasentada mural hipertrofi önemli ölçüde daha yüksek oranda bulundu.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | SAHIN O, Altay A, Aydın E, Bağcı H, Yalçın Ö (2022). Effect of asymptomatic COVID-19 infection on the placenta in the third trimester of pregnancy: A prospective case-control study. , 178 - 186. 10.4274/tjod.galenos.2022.94984 |
| Chicago | SAHIN Orhan,Altay Ali Yılmaz,Aydın Emine,Bağcı Helin,Yalçın Özben Effect of asymptomatic COVID-19 infection on the placenta in the third trimester of pregnancy: A prospective case-control study. (2022): 178 - 186. 10.4274/tjod.galenos.2022.94984 |
| MLA | SAHIN Orhan,Altay Ali Yılmaz,Aydın Emine,Bağcı Helin,Yalçın Özben Effect of asymptomatic COVID-19 infection on the placenta in the third trimester of pregnancy: A prospective case-control study. , 2022, ss.178 - 186. 10.4274/tjod.galenos.2022.94984 |
| AMA | SAHIN O,Altay A,Aydın E,Bağcı H,Yalçın Ö Effect of asymptomatic COVID-19 infection on the placenta in the third trimester of pregnancy: A prospective case-control study. . 2022; 178 - 186. 10.4274/tjod.galenos.2022.94984 |
| Vancouver | SAHIN O,Altay A,Aydın E,Bağcı H,Yalçın Ö Effect of asymptomatic COVID-19 infection on the placenta in the third trimester of pregnancy: A prospective case-control study. . 2022; 178 - 186. 10.4274/tjod.galenos.2022.94984 |
| IEEE | SAHIN O,Altay A,Aydın E,Bağcı H,Yalçın Ö "Effect of asymptomatic COVID-19 infection on the placenta in the third trimester of pregnancy: A prospective case-control study." , ss.178 - 186, 2022. 10.4274/tjod.galenos.2022.94984 |
| ISNAD | SAHIN, Orhan vd. "Effect of asymptomatic COVID-19 infection on the placenta in the third trimester of pregnancy: A prospective case-control study". (2022), 178-186. https://doi.org/10.4274/tjod.galenos.2022.94984 |
| APA | SAHIN O, Altay A, Aydın E, Bağcı H, Yalçın Ö (2022). Effect of asymptomatic COVID-19 infection on the placenta in the third trimester of pregnancy: A prospective case-control study. Turkish Journal of Obstetrics and Gynecology, 19(3), 178 - 186. 10.4274/tjod.galenos.2022.94984 |
| Chicago | SAHIN Orhan,Altay Ali Yılmaz,Aydın Emine,Bağcı Helin,Yalçın Özben Effect of asymptomatic COVID-19 infection on the placenta in the third trimester of pregnancy: A prospective case-control study. Turkish Journal of Obstetrics and Gynecology 19, no.3 (2022): 178 - 186. 10.4274/tjod.galenos.2022.94984 |
| MLA | SAHIN Orhan,Altay Ali Yılmaz,Aydın Emine,Bağcı Helin,Yalçın Özben Effect of asymptomatic COVID-19 infection on the placenta in the third trimester of pregnancy: A prospective case-control study. Turkish Journal of Obstetrics and Gynecology, vol.19, no.3, 2022, ss.178 - 186. 10.4274/tjod.galenos.2022.94984 |
| AMA | SAHIN O,Altay A,Aydın E,Bağcı H,Yalçın Ö Effect of asymptomatic COVID-19 infection on the placenta in the third trimester of pregnancy: A prospective case-control study. Turkish Journal of Obstetrics and Gynecology. 2022; 19(3): 178 - 186. 10.4274/tjod.galenos.2022.94984 |
| Vancouver | SAHIN O,Altay A,Aydın E,Bağcı H,Yalçın Ö Effect of asymptomatic COVID-19 infection on the placenta in the third trimester of pregnancy: A prospective case-control study. Turkish Journal of Obstetrics and Gynecology. 2022; 19(3): 178 - 186. 10.4274/tjod.galenos.2022.94984 |
| IEEE | SAHIN O,Altay A,Aydın E,Bağcı H,Yalçın Ö "Effect of asymptomatic COVID-19 infection on the placenta in the third trimester of pregnancy: A prospective case-control study." Turkish Journal of Obstetrics and Gynecology, 19, ss.178 - 186, 2022. 10.4274/tjod.galenos.2022.94984 |
| ISNAD | SAHIN, Orhan vd. "Effect of asymptomatic COVID-19 infection on the placenta in the third trimester of pregnancy: A prospective case-control study". Turkish Journal of Obstetrics and Gynecology 19/3 (2022), 178-186. https://doi.org/10.4274/tjod.galenos.2022.94984 |
