The role of inflammation, oxidation and Cystatin-C in the pathophysiology of polycystic ovary syndrome
Yıl: 2022 Cilt: 19 Sayı: 3 Sayfa Aralığı: 229 - 235 Metin Dili: İngilizce DOI: 10.4274/tjod.galenos.2022.29498 İndeks Tarihi: 27-10-2022
The role of inflammation, oxidation and Cystatin-C in the pathophysiology of polycystic ovary syndrome
Öz: Objective: The relationship between Cystatin-C levels and inflammatory, oxidant, and antioxidant markers in polycystic ovary syndrome (PCOS) was investigated. Materials and Methods: A total of 96 participants were included in the study as PCOS (n=58) and control (n=38) groups. Tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1B), interleukin 6 (IL-6), malondialdehyde (MDA), superoxide dismutase (SOD), and Cystatin-C were evaluated by ELISA method. Relationships metabolic and endocrine parameters seen in PCOS were examined. Univariate and multivariate logistic regression analyzes were performed to identify risk factors that may affect the PCOS group. Bivariate correlations were investigated by the Spearman’s correlation analysis. Results: While Cystatin-c, TNF-α, IL-1B, IL-6, MDA were found to be higher in patients with PCOS compared with the control group, SOD was found to be lower than the control group (p<0.05). In the correlation analysis, increased Cystatin-C levels were found to be associated with high IL-6 (r=0.214, p=0.037) and low SOD levels (r=-0.280, p=0.006). Conclusion: In our study, it was found that the increase in Cystatin-C levels was associated with an increase in IL-6 and a decrease in SOD. These results may bring up different treatment options to reduce cardiovascular risks for treating PCOS.
Anahtar Kelime: Polikistik over sendromunun patofizyolojisinde enflamasyon, oksidasyon ve Sistatin-C’nin rolü
Öz: Amaç: Polikistik over sendromunda (PKOS) Sistatin-C düzeyleri ile enflamatuvar, oksidan ve antioksidan belirteçler arasındaki ilişkinin araştırılması amaçlandı. Gereç ve Yöntemler: Çalışmaya PKOS (n=58) ve kontrol (n=38) grubu olarak toplam 96 katılımcı dahil edildi. Tümör nekroz faktör-alfa (TNF-α), interlökin-1 beta (IL-1B), interlökin 6 (IL-6), malondialdehit (MDA), süperoksit dismutaz (SOD) ve Sistatin-C markerları ELISA yöntemi ile değerlendirildi. PKOS grubunu etkileyebilecek olası risk faktörlerini belirlemek için tek değişkenli ve çok değişkenli lojistik regresyon analizi yapıldı. İki değişkenli korelasyonlar Spearman korelasyon analizi ile araştırıldı. Bulgular: PKOS hastalarında Sistatin-C, TNF-α, IL-1B, IL-6, MDA, kontrol grubuna göre daha anlamlı olarak yüksek bulunurken, kontrol grubunda SOD daha yüksek bulundu (p<0,05). Korelasyon analizinde, artan Sistatin-C seviyeleri, yüksek IL-6 (r=0,214, p=0,037) ve düşük SOD seviyeleri (r=-0,280, p=0,006) ile ilişkili bulundu. Sonuç: Çalışmamızda kardiyovasküler hastalık belirteci olan Sistatin-C düzeylerindeki artışın yüksek IL-6 ve düşük SOD seviyeleri ile ilişkili olduğu bulundu. Bu sonuçlar PKOS tedavisinde kardiyovasküler riskleri azaltmak için farklı tedavi seçeneklerini gündeme getirebilir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | başer ö, göçmen a, Aydoğan kırmızı D (2022). The role of inflammation, oxidation and Cystatin-C in the pathophysiology of polycystic ovary syndrome. , 229 - 235. 10.4274/tjod.galenos.2022.29498 |
| Chicago | başer özden,göçmen ayşe yeşim,Aydoğan kırmızı Demet The role of inflammation, oxidation and Cystatin-C in the pathophysiology of polycystic ovary syndrome. (2022): 229 - 235. 10.4274/tjod.galenos.2022.29498 |
| MLA | başer özden,göçmen ayşe yeşim,Aydoğan kırmızı Demet The role of inflammation, oxidation and Cystatin-C in the pathophysiology of polycystic ovary syndrome. , 2022, ss.229 - 235. 10.4274/tjod.galenos.2022.29498 |
| AMA | başer ö,göçmen a,Aydoğan kırmızı D The role of inflammation, oxidation and Cystatin-C in the pathophysiology of polycystic ovary syndrome. . 2022; 229 - 235. 10.4274/tjod.galenos.2022.29498 |
| Vancouver | başer ö,göçmen a,Aydoğan kırmızı D The role of inflammation, oxidation and Cystatin-C in the pathophysiology of polycystic ovary syndrome. . 2022; 229 - 235. 10.4274/tjod.galenos.2022.29498 |
| IEEE | başer ö,göçmen a,Aydoğan kırmızı D "The role of inflammation, oxidation and Cystatin-C in the pathophysiology of polycystic ovary syndrome." , ss.229 - 235, 2022. 10.4274/tjod.galenos.2022.29498 |
| ISNAD | başer, özden vd. "The role of inflammation, oxidation and Cystatin-C in the pathophysiology of polycystic ovary syndrome". (2022), 229-235. https://doi.org/10.4274/tjod.galenos.2022.29498 |
| APA | başer ö, göçmen a, Aydoğan kırmızı D (2022). The role of inflammation, oxidation and Cystatin-C in the pathophysiology of polycystic ovary syndrome. Turkish Journal of Obstetrics and Gynecology, 19(3), 229 - 235. 10.4274/tjod.galenos.2022.29498 |
| Chicago | başer özden,göçmen ayşe yeşim,Aydoğan kırmızı Demet The role of inflammation, oxidation and Cystatin-C in the pathophysiology of polycystic ovary syndrome. Turkish Journal of Obstetrics and Gynecology 19, no.3 (2022): 229 - 235. 10.4274/tjod.galenos.2022.29498 |
| MLA | başer özden,göçmen ayşe yeşim,Aydoğan kırmızı Demet The role of inflammation, oxidation and Cystatin-C in the pathophysiology of polycystic ovary syndrome. Turkish Journal of Obstetrics and Gynecology, vol.19, no.3, 2022, ss.229 - 235. 10.4274/tjod.galenos.2022.29498 |
| AMA | başer ö,göçmen a,Aydoğan kırmızı D The role of inflammation, oxidation and Cystatin-C in the pathophysiology of polycystic ovary syndrome. Turkish Journal of Obstetrics and Gynecology. 2022; 19(3): 229 - 235. 10.4274/tjod.galenos.2022.29498 |
| Vancouver | başer ö,göçmen a,Aydoğan kırmızı D The role of inflammation, oxidation and Cystatin-C in the pathophysiology of polycystic ovary syndrome. Turkish Journal of Obstetrics and Gynecology. 2022; 19(3): 229 - 235. 10.4274/tjod.galenos.2022.29498 |
| IEEE | başer ö,göçmen a,Aydoğan kırmızı D "The role of inflammation, oxidation and Cystatin-C in the pathophysiology of polycystic ovary syndrome." Turkish Journal of Obstetrics and Gynecology, 19, ss.229 - 235, 2022. 10.4274/tjod.galenos.2022.29498 |
| ISNAD | başer, özden vd. "The role of inflammation, oxidation and Cystatin-C in the pathophysiology of polycystic ovary syndrome". Turkish Journal of Obstetrics and Gynecology 19/3 (2022), 229-235. https://doi.org/10.4274/tjod.galenos.2022.29498 |
