TY  - JOUR
TI  - Histopathological and Immunohistochemical Evaluation of  84 Uterine Sarcomas According to Current Literature
AB  - OBJECTIVE It was aimed to reevaluate uterine sarcoma cases diagnosed in our institution within the last 20 years  according to current information and to provide intra-departmental standardization in the differential  diagnosis and reporting. METHODS Totally 84 uterine sarcoma cases were re-examined. Recurrence, metastasis, and prognostic data were  collected from the patient files. Immunohistochemistry panel consisting of CD10, h-caldesmon, and  cyclin D1 was applied to the representative tumor tissues. The relationships between the parameters  studied were evaluated statistically. RESULTS Statistically significant differences were found between different histopathological types of uterine sar comas (US) in terms of age distribution, tumor diameter, mitotic index, necrosis, depth of myometrial  invasion, cervical, adnexial and/or omental involvement, lymphovascular invasion, lymph node metas tasis, recurrence, and distant metastasis. Statistically significant correlation was determined between the  prognosis of the patients and mitotic activity of their tumors and the presence of distant metastasis. The  immunohistochemistry panel was found to have significant contribution to the histomorphological ex amination in the differential diagnosis. CONCLUSION Routine use of CD10, h-caldesmon, and cyclin D1 in the histopathological evaluation of US and es tablishing an updated standard checklist was thought to be beneficial for the differential diagnosis and  reporting prognostic parameters.
AU  - DUMAN ÖZTÜRK, Seda
AU  - Kaçar Özkara, Sevgiye
AU  - Turan, Gupse
DO  - 10.5505/tjo.2021.3380
PY  - 2022
JO  - Türk Onkoloji Dergisi
VL  - 37
IS  - 1
SN  - 1300-7467
SP  - 51
EP  - 59
DB  - TRDizin
UR  - http://search/yayin/detay/1135788
ER  -