Yıl: 2022 Cilt: 38 Sayı: 3 Sayfa Aralığı: 289 - 293 Metin Dili: İngilizce DOI: 10.47717/turkjsurg.2022.4790 İndeks Tarihi: 31-10-2022

Duration of operation and diagnosis of hepatitis B (HBV) is an independent risk factor for surgical site infections after liver transplantation

Öz:
Objective: Surgical site infections (SSI) are the most common complications after liver transplantation (LT). Although there are some risk factors known in the literature after LT, the available data is insufficient for routine use. In the present study, it was aimed to define the parameters that may be used to clearly determine the risk of SSI after LT in our clinic. Material and Methods: In the present study, we evaluated 329 patients who underwent liver transplantation with regard to risk factors for surgical site infections. The relation between demographic data and SSI was evaluated using SPSS, Graphpad, and Medcalc statistical programs. Results: In a total of 329 patients, SSIs were determined in 37 (11.24%). Among the 37 patients, 24 were classified as organ space (64.9%) and 13 as deep SSI (35.1%). None of these patients developed superficial incisional infection. SSI showed statistically significant relation with operation time (p= 0.008), diabetes (p= 0.004), and cirrhosis due to hepatitis B (p< 0.001). Conclusion: As a result, deep and organ space infections are much more observed in patients undergoing liver transplantation with hepatitis B, diabetes mellitus and prolonged surgery. This is thought to have developed because of chronic irritation and increased inflammation. Since data on hepatitis B and duration of surgery are limited in the literature, this study is considered to be a contribution to the literature.
Anahtar Kelime:

Hepatit B (HBV) tanısı ve operasyon süresi karaciğer transplantasyonu sonrası cerrahi alan enfeksiyonları için bağımsız bir risk faktörüdür

Öz:
Giriş ve Amaç: Cerrahi alan enfeksiyonları (CAE), karaciğer nakli (KN) sonra en sık görülen komplikasyonlardan biridir. Literatürde KN sonrası bilinen bazı risk faktörleri olmasına rağmen, mevcut veriler rutin kullanım için yetersizdir. Bu çalışmada, kliniğimizde KN sonrası CAE riskini açıkça belirlemek için kullanılabilecek parametrelerin tanımlanması amaçlanmıştır. Gereç ve Yöntem: Bu çalışmada, KN uygulanan 232 hastayı değerlendirdik. Demografik veriler ve CAE arasındaki ilişki SPSS, Graphpad, Medcalc istatistik programları kullanılarak analiz edilmiştir. Bulgular: Toplam 232 hastada 26 (%11,26) CAE saptandı. 26 hastanın 16’sı organ boşluk 16 (61,5) ve 10’u (39,5) derin CAE olarak sınıflandırıldı. Bu hastaların hiçbirinde yüzeysel cerrahi alan enfeksiyonu gelişmedi.Derin ve organ boşluk SS, operasyon süresi (p= 0,01), diyabet (p= 0,004), HBV enfeksiyonu (p= 0,001) arasında istatistiksel olarak anlamlı ilişki saptandı. Sonuç: Sonuç olarak, karaciğer nakli uygulanan hepatit B tanısı olan, diyabetik ve ameliyat süresi uzayan hastalarda daha fazla derin ve organ boşluk enfeksiyonu geliştiği görülmektedir. Bunun da kronik irritasyon ve artmış enflamasyon sonucunda geliştiği düşünülmüştür. Literatürde hepatit B ve ameliyat süresi ile ilgili veriler kısıtlı olduğundan bu çalışmanın literatüre katkı sağlayabileceği düşünülmüştür.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
  • 1. Oliveira RA, Mancero JMP, Faria DF, Poveda VB. A retrospective cohort study of risk factors for surgical site infection following liver transplantation. Prog Transplant 2019; 29: 144-9. https://doi. org/10.1177/1526924819835831
  • 2. GlobalSurg Collaborative. Surgical site infection after gastrointestinal surgery in high-income, middle- income, and low-income countries: a prospective, international, multicentre cohort study. Lancet Infect Dis 2018; 18: 516-25. https://doi.org/10.1016/S1473-3099(18)30101-4
  • 3. Hellinger WC, Crook JE, Heckman MG, Diehl NN, Shalev JA, Zubair AC, et al. Surgical site infection after liver transplantation: risk factors and association with graft loss or death. Transplantation 2009; 87: 1387- 93. https://doi.org/10.1097/TP.0b013e3181a25133
  • 4. Oliveira RA, Turrini RNT, Poveda VB. Risk factors for development of surgical site infections among liver transplantation recipients: an integrative literature review. Am J Infect Control 2018; 46: 88-93. https:// doi.org/10.1016/j.ajic.2017.05.021
  • 5. Vasavada B, Chen CL. Vascular complications in biliary atresia patients undergoing living do-nor liver transplantation: Analysis of 110 patients over 10 years. J Indian Assoc Pediatr Surg 2015; 20: 121-6. https://doi.org/10.4103/0971-9261.154651
  • 6. Avkan-Oguz V, Ozkardesler S, Unek T, Ozbilgin M, Akan M, Firuzan E, et al.Risk factors for early bacterial infections in liver transplantation. Transplant Proc 2013; 45: 993-7. https://doi.org/10.1016/j.transproceed. 2013.02.067
  • 7. Antunes M, Teixeira A, Fortuna P, Moya B, Martins A, Bagulho L, et al. Infections after liver transplantation: A retrospective, single-center study. Transplant Proc 2015; 47: 1019-24. https://doi.org/10.1016/j. transproceed.2015.03.009
  • 8. Abbo LM , Grossi PA. Surgical site infections: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transplant 2019; 33: e13589. https://doi.org/10.1111/ ctr.13589
  • 9. Softness KA, ElSabbagh A, Kroemer A, Hawksworth J, Matsumoto Cal S, Fishbein T, et al. Surgical site infection after liver transplantation: Single-center. Experience Int J Transplant Res Med 2018; 4: 037.
  • 10. Oliveira RA, Mancero JMP, Faria DF, Poveda VB. A retrospective cohort study of risk fac-tors for surgical site infection following liver transplantation progress in transplantation. Prog Transplant 2019; 29: 144-9. https://doi.org/10.1177/1526924819835831
  • 11. Freire MP, Song ATW, Oshiro ICV, Andraus W, D’Albuquerque LAC, Abdala E. Surgical site infection after liver transplantation in the era of multidrug- resistant bacteria: What new risks should be considered? Diagn Micr Infec Dis 2021; 99: 115220. https://doi.org/10.1016/j.diagmicrobio. 2020.115220
  • 12. Martin ET, Kaye KS, Knott C, Nguyen H, Santarossa M, Evans R, et al. Diabetes and risk of surgical site infection: A systematic review and meta- analysis. Infect Control Hosp Epidemi-ol 2016; 37: 88-99. https:// doi.org/10.1017/ice.2015.249
  • 13. Sangrasi AK, Leghari AA, Memon A, Talpur AK, Qureshi GA, Memon JM, et al. Surgical site infection rate and associated risk factors in elective general surgery at a public sector medi-cal university in Pakistan. Int Wound J 2008; 5: 74-8. https://doi.org/10.1111/j.1742- 481X.2007.00365.x
  • 14. Isik O, Kaya E, Dündar HZ, Sarkut P. Surgical site infection: Reassessment of the risk factors. Chirurgia 2015; 110: 457-61.
  • 15. Malone DL, Genuit T, Tracy JK, Gannon C, Napolitano LM. Surgical site infections: Re-analysis of risk factors. J Surg Res. 2002; 103: 89-95. https://doi.org/10.1006/jsre.2001.6343
APA Aksoy F, dündar h, Kaya E (2022). Duration of operation and diagnosis of hepatitis B (HBV) is an independent risk factor for surgical site infections after liver transplantation. , 289 - 293. 10.47717/turkjsurg.2022.4790
Chicago Aksoy Fuat,dündar halit ziya,Kaya Ekrem Duration of operation and diagnosis of hepatitis B (HBV) is an independent risk factor for surgical site infections after liver transplantation. (2022): 289 - 293. 10.47717/turkjsurg.2022.4790
MLA Aksoy Fuat,dündar halit ziya,Kaya Ekrem Duration of operation and diagnosis of hepatitis B (HBV) is an independent risk factor for surgical site infections after liver transplantation. , 2022, ss.289 - 293. 10.47717/turkjsurg.2022.4790
AMA Aksoy F,dündar h,Kaya E Duration of operation and diagnosis of hepatitis B (HBV) is an independent risk factor for surgical site infections after liver transplantation. . 2022; 289 - 293. 10.47717/turkjsurg.2022.4790
Vancouver Aksoy F,dündar h,Kaya E Duration of operation and diagnosis of hepatitis B (HBV) is an independent risk factor for surgical site infections after liver transplantation. . 2022; 289 - 293. 10.47717/turkjsurg.2022.4790
IEEE Aksoy F,dündar h,Kaya E "Duration of operation and diagnosis of hepatitis B (HBV) is an independent risk factor for surgical site infections after liver transplantation." , ss.289 - 293, 2022. 10.47717/turkjsurg.2022.4790
ISNAD Aksoy, Fuat vd. "Duration of operation and diagnosis of hepatitis B (HBV) is an independent risk factor for surgical site infections after liver transplantation". (2022), 289-293. https://doi.org/10.47717/turkjsurg.2022.4790
APA Aksoy F, dündar h, Kaya E (2022). Duration of operation and diagnosis of hepatitis B (HBV) is an independent risk factor for surgical site infections after liver transplantation. Turkish Journal of Surgery, 38(3), 289 - 293. 10.47717/turkjsurg.2022.4790
Chicago Aksoy Fuat,dündar halit ziya,Kaya Ekrem Duration of operation and diagnosis of hepatitis B (HBV) is an independent risk factor for surgical site infections after liver transplantation. Turkish Journal of Surgery 38, no.3 (2022): 289 - 293. 10.47717/turkjsurg.2022.4790
MLA Aksoy Fuat,dündar halit ziya,Kaya Ekrem Duration of operation and diagnosis of hepatitis B (HBV) is an independent risk factor for surgical site infections after liver transplantation. Turkish Journal of Surgery, vol.38, no.3, 2022, ss.289 - 293. 10.47717/turkjsurg.2022.4790
AMA Aksoy F,dündar h,Kaya E Duration of operation and diagnosis of hepatitis B (HBV) is an independent risk factor for surgical site infections after liver transplantation. Turkish Journal of Surgery. 2022; 38(3): 289 - 293. 10.47717/turkjsurg.2022.4790
Vancouver Aksoy F,dündar h,Kaya E Duration of operation and diagnosis of hepatitis B (HBV) is an independent risk factor for surgical site infections after liver transplantation. Turkish Journal of Surgery. 2022; 38(3): 289 - 293. 10.47717/turkjsurg.2022.4790
IEEE Aksoy F,dündar h,Kaya E "Duration of operation and diagnosis of hepatitis B (HBV) is an independent risk factor for surgical site infections after liver transplantation." Turkish Journal of Surgery, 38, ss.289 - 293, 2022. 10.47717/turkjsurg.2022.4790
ISNAD Aksoy, Fuat vd. "Duration of operation and diagnosis of hepatitis B (HBV) is an independent risk factor for surgical site infections after liver transplantation". Turkish Journal of Surgery 38/3 (2022), 289-293. https://doi.org/10.47717/turkjsurg.2022.4790