Can chlorogenic acid reduce oxidative stress and in an experimental spinal cord injury?

Ercan BAL, (Ankara Yıldırım Beyazıt Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Ankara, Türkiye)
Şahin HANALIOĞLU, (Ankara Hacettepe Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Ankara, Türkiye)
Aydın Sinan APAYDIN, (Ankara Şehir Hastanesi, Nöroşirürji Anabilim Dalı, Ankara, Türkiye)
Ceylan BAL, (Ankara Yıldırım Beyazıt Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Ankara, Türkiye)
Almila ŞENAT, (Ankara Yıldırım Beyazıt Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Ankara, Türkiye)
Berrak ÖCAL, (Ankara Yıldırım Beyazıt Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Ankara, Türkiye)
Burak BAHADIR, (Ankara Şehir Hastanesi, Nöroşirürji Anabilim Dalı, Ankara, Türkiye)
Ömer Faruk TÜRKOĞLU (Ankara Şehir Hastanesi, Nöroşirürji Anabilim Dalı, Ankara, Türkiye)
Ulusal Travma ve Acil Cerrahi Dergisi
0 0
Yıl: 2022 Cilt: 28 Sayı: 2 Sayfa Aralığı: 125 - 133 Metin Dili: İngilizce DOI: 10.14744/tjtes.2020.89499 İndeks Tarihi: 01-11-2022

Can chlorogenic acid reduce oxidative stress and in an experimental spinal cord injury?

Öz:
BACKGROUND: We aimed to investigate antioxidant and neuroprotective properties of chlorogenic acid in spinal cord injury (SCI). METHODS: Twenty-one rats were divided into three groups. Laminectomy was performed in group L (n=7), spinal cord trauma was induced in group T (n=7), and spinal cord trauma was induced and chlorogenic acid treatment was started in group C (n=7). Blood samples were collected to analyze baseline values and the 12th h, 1st day, 3rd day, and 5th day catalase, native thiol (NT), total thiol (TT), disulfide (SS), SS/TT, SS/NT, and NT/TT levels. Functional analysis with Basso-Beattie and Bresnahan scores was performed at the same time points. Total antioxidant status (TAS), total oxidative stress, oxidative stress index, and cyclooxygenase-2 (Cox-2) were examined in the spinal cord of rats euthanized on day 7; results were statistically analyzed. RESULTS: On day 7, catalase levels in Group C were significantly higher than baseline levels, whereas those in Group T were signifi cantly lower than baseline levels; Group L showed no significant difference (p=0.008). SS values on day 7 were lower in Group T than in Groups C and L. Group C showed the lowest decrease in NT/TT level after trauma. On day 7, SS/TT level was high in Group T but stable in Groups C and L (p=0.04). Histopathological examination revealed significantly lower Cox-2 and TAS levels in Group C than in Group T (p=0.003, p=0.017, respectively). CONCLUSION: In this study, SCI was primarily examined through thiol-SS balance, and it was demonstrated by experimental mod els that chlorogenic acid has antioxidant and neuroprotective effects in SCI.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Diğer Erişim Türü: Erişime Açık
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APA Bal E, Hanalioglu S, Apaydin A, bal c, ŞENAT A, Gumuskaya B, BAHADIR B, Turkoglu O (2022). Can chlorogenic acid reduce oxidative stress and in an experimental spinal cord injury?. , 125 - 133. 10.14744/tjtes.2020.89499
Chicago Bal Ercan,Hanalioglu Sahin,Apaydin Aydın Sinan,bal ceylan,ŞENAT Almila,Gumuskaya Berrak,BAHADIR BURAK,Turkoglu Omer Faruk Can chlorogenic acid reduce oxidative stress and in an experimental spinal cord injury?. (2022): 125 - 133. 10.14744/tjtes.2020.89499
MLA Bal Ercan,Hanalioglu Sahin,Apaydin Aydın Sinan,bal ceylan,ŞENAT Almila,Gumuskaya Berrak,BAHADIR BURAK,Turkoglu Omer Faruk Can chlorogenic acid reduce oxidative stress and in an experimental spinal cord injury?. , 2022, ss.125 - 133. 10.14744/tjtes.2020.89499
AMA Bal E,Hanalioglu S,Apaydin A,bal c,ŞENAT A,Gumuskaya B,BAHADIR B,Turkoglu O Can chlorogenic acid reduce oxidative stress and in an experimental spinal cord injury?. . 2022; 125 - 133. 10.14744/tjtes.2020.89499
Vancouver Bal E,Hanalioglu S,Apaydin A,bal c,ŞENAT A,Gumuskaya B,BAHADIR B,Turkoglu O Can chlorogenic acid reduce oxidative stress and in an experimental spinal cord injury?. . 2022; 125 - 133. 10.14744/tjtes.2020.89499
IEEE Bal E,Hanalioglu S,Apaydin A,bal c,ŞENAT A,Gumuskaya B,BAHADIR B,Turkoglu O "Can chlorogenic acid reduce oxidative stress and in an experimental spinal cord injury?." , ss.125 - 133, 2022. 10.14744/tjtes.2020.89499
ISNAD Bal, Ercan vd. "Can chlorogenic acid reduce oxidative stress and in an experimental spinal cord injury?". (2022), 125-133. https://doi.org/10.14744/tjtes.2020.89499
APA Bal E, Hanalioglu S, Apaydin A, bal c, ŞENAT A, Gumuskaya B, BAHADIR B, Turkoglu O (2022). Can chlorogenic acid reduce oxidative stress and in an experimental spinal cord injury?. Ulusal Travma ve Acil Cerrahi Dergisi, 28(2), 125 - 133. 10.14744/tjtes.2020.89499
Chicago Bal Ercan,Hanalioglu Sahin,Apaydin Aydın Sinan,bal ceylan,ŞENAT Almila,Gumuskaya Berrak,BAHADIR BURAK,Turkoglu Omer Faruk Can chlorogenic acid reduce oxidative stress and in an experimental spinal cord injury?. Ulusal Travma ve Acil Cerrahi Dergisi 28, no.2 (2022): 125 - 133. 10.14744/tjtes.2020.89499
MLA Bal Ercan,Hanalioglu Sahin,Apaydin Aydın Sinan,bal ceylan,ŞENAT Almila,Gumuskaya Berrak,BAHADIR BURAK,Turkoglu Omer Faruk Can chlorogenic acid reduce oxidative stress and in an experimental spinal cord injury?. Ulusal Travma ve Acil Cerrahi Dergisi, vol.28, no.2, 2022, ss.125 - 133. 10.14744/tjtes.2020.89499
AMA Bal E,Hanalioglu S,Apaydin A,bal c,ŞENAT A,Gumuskaya B,BAHADIR B,Turkoglu O Can chlorogenic acid reduce oxidative stress and in an experimental spinal cord injury?. Ulusal Travma ve Acil Cerrahi Dergisi. 2022; 28(2): 125 - 133. 10.14744/tjtes.2020.89499
Vancouver Bal E,Hanalioglu S,Apaydin A,bal c,ŞENAT A,Gumuskaya B,BAHADIR B,Turkoglu O Can chlorogenic acid reduce oxidative stress and in an experimental spinal cord injury?. Ulusal Travma ve Acil Cerrahi Dergisi. 2022; 28(2): 125 - 133. 10.14744/tjtes.2020.89499
IEEE Bal E,Hanalioglu S,Apaydin A,bal c,ŞENAT A,Gumuskaya B,BAHADIR B,Turkoglu O "Can chlorogenic acid reduce oxidative stress and in an experimental spinal cord injury?." Ulusal Travma ve Acil Cerrahi Dergisi, 28, ss.125 - 133, 2022. 10.14744/tjtes.2020.89499
ISNAD Bal, Ercan vd. "Can chlorogenic acid reduce oxidative stress and in an experimental spinal cord injury?". Ulusal Travma ve Acil Cerrahi Dergisi 28/2 (2022), 125-133. https://doi.org/10.14744/tjtes.2020.89499
Sayfa Oluşturulma Tarihi
24-04-2024 4:23

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