TY  - JOUR
TI  - Early Effect of Radiotherapy on Serum Levels of HSP70 and S100B in Patients with Breast Cancer
AB  - OBJECTIVE This study aimed to evaluate the difference between serum levels of S100B and HSP70 in the non-meta- static, Luminal A breast cancer (BC) patients with the healthy population, and determine the impact of post-operative radiotherapy (RT) on serum markers. METHODS 21 BC patients who underwent chest wall/breast±axillary RT after adjuvant chemotherapy and twenty- one healthy individuals were included in the study group. The changes in serum HSP70 and S100B levels were observed in the study and control groups. RESULTS A total of 42 participants were included. A significant difference was found between the HSP70 and S100B measurements of the study and control groups before and after RT (P=0.001 and p<0.01, re- spectively). At the same time, the increase in HSP70 after RT was statistically significant (p=0.025 and p<0.05, respectively). However, the change in S100B measurements after RT was not statistically signifi- cant in the study group patients compared to before RT (p>0.627). CONCLUSION S100B and HSP70 levels are higher than the healthy population before and after RT in non-metastatic, luminal A BC patients. The significant increase in Hsp70 after RT may be due to the release from dying tumor cells in the microenvironment. Therefore, HSP70 levels in the blood may be useful for micro- scopic tumor focus detection or evaluation of treatment response.
AU  - Gedikbasi, Asuman
AU  - Soydemir, Gülşen Pınar
AU  - Sahingoz Erdal, Gulcin
AU  - Isiksacan, Nilgun
AU  - Kırlı, Meltem
AU  - Ozer, elif eda
DO  - 10.5505/tjo.2022.3335
PY  - 2022
JO  - Türk Onkoloji Dergisi
VL  - 37
IS  - 2
SN  - 1300-7467
SP  - 115
EP  - 121
DB  - TRDizin
UR  - http://search/yayin/detay/1136676
ER  -