Oxidative Stress Has a Negative Effect on the Development and Progression of Bladder Cancer

DEMİR, Canan; Demir, Murat

doi:10.5505/tjo.2022.3453

Oxidative Stress Has a Negative Effect on the Development and Progression of Bladder Cancer

Murat DEMİR, (van Yüzüncü Yıl Üniversitesi Üroloji Anabilim Dalı, Van, Türkiye)

Canan DEMİR (VAN Yüzüncü Yıl Üniversitesi, Sağlık Yüksekokulu, Tıbbi Dokümantasyon ve Sekreterlik Bölümü Hizmetler, Van, Türkiye)

Türk Onkoloji Dergisi

2 0

Yıl: 2022 Cilt: 37 Sayı: 2 Sayfa Aralığı: 158 - 162 Metin Dili: İngilizce DOI: 10.5505/tjo.2022.3453 İndeks Tarihi: 01-11-2022

Oxidative Stress Has a Negative Effect on the Development and Progression of Bladder Cancer

Öz:

OBJECTIVE In this study, we aimed to investigate the oxidant-antioxidant capacity in bladder cancer according to invasion and degree. METHODS Forty-six patients with bladder cancer and 50 healthy volunteers were included in the study. After 12 h of fasting, 4cc of blood venous blood was taken from these patients. Then, after centrifugation at 5000 rpms for 10 min, the serum portion of the study was completed. The activities of arylesterase (ARE), paraoxanase-1 (PON-1), glutathione reductase (GR), glutathione-S transferase, and protein carbonyl (PC) in serum were measured spectrophotometrically. RESULTS Antioxidant parameters in the serum of patients with bladder tumors were found lower than control group (p=0.001). In addition, PC was found to be higher in the bladder cancer group than in the control group (p=0.001); on the other hand, ARE, PON-1, and GR levels were found to be lower in both high- grade tumors and invasive tumors (p≤0.05). CONCLUSION Oxidative stress is effective in the development and progression of bladder tumors.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Demir M, DEMİR C (2022). Oxidative Stress Has a Negative Effect on the Development and Progression of Bladder Cancer. , 158 - 162. 10.5505/tjo.2022.3453
Chicago	Demir Murat,DEMİR Canan Oxidative Stress Has a Negative Effect on the Development and Progression of Bladder Cancer. (2022): 158 - 162. 10.5505/tjo.2022.3453
MLA	Demir Murat,DEMİR Canan Oxidative Stress Has a Negative Effect on the Development and Progression of Bladder Cancer. , 2022, ss.158 - 162. 10.5505/tjo.2022.3453
AMA	Demir M,DEMİR C Oxidative Stress Has a Negative Effect on the Development and Progression of Bladder Cancer. . 2022; 158 - 162. 10.5505/tjo.2022.3453
Vancouver	Demir M,DEMİR C Oxidative Stress Has a Negative Effect on the Development and Progression of Bladder Cancer. . 2022; 158 - 162. 10.5505/tjo.2022.3453
IEEE	Demir M,DEMİR C "Oxidative Stress Has a Negative Effect on the Development and Progression of Bladder Cancer." , ss.158 - 162, 2022. 10.5505/tjo.2022.3453
ISNAD	Demir, Murat - DEMİR, Canan. "Oxidative Stress Has a Negative Effect on the Development and Progression of Bladder Cancer". (2022), 158-162. https://doi.org/10.5505/tjo.2022.3453

APA	Demir M, DEMİR C (2022). Oxidative Stress Has a Negative Effect on the Development and Progression of Bladder Cancer. Türk Onkoloji Dergisi, 37(2), 158 - 162. 10.5505/tjo.2022.3453
Chicago	Demir Murat,DEMİR Canan Oxidative Stress Has a Negative Effect on the Development and Progression of Bladder Cancer. Türk Onkoloji Dergisi 37, no.2 (2022): 158 - 162. 10.5505/tjo.2022.3453
MLA	Demir Murat,DEMİR Canan Oxidative Stress Has a Negative Effect on the Development and Progression of Bladder Cancer. Türk Onkoloji Dergisi, vol.37, no.2, 2022, ss.158 - 162. 10.5505/tjo.2022.3453
AMA	Demir M,DEMİR C Oxidative Stress Has a Negative Effect on the Development and Progression of Bladder Cancer. Türk Onkoloji Dergisi. 2022; 37(2): 158 - 162. 10.5505/tjo.2022.3453
Vancouver	Demir M,DEMİR C Oxidative Stress Has a Negative Effect on the Development and Progression of Bladder Cancer. Türk Onkoloji Dergisi. 2022; 37(2): 158 - 162. 10.5505/tjo.2022.3453
IEEE	Demir M,DEMİR C "Oxidative Stress Has a Negative Effect on the Development and Progression of Bladder Cancer." Türk Onkoloji Dergisi, 37, ss.158 - 162, 2022. 10.5505/tjo.2022.3453
ISNAD	Demir, Murat - DEMİR, Canan. "Oxidative Stress Has a Negative Effect on the Development and Progression of Bladder Cancer". Türk Onkoloji Dergisi 37/2 (2022), 158-162. https://doi.org/10.5505/tjo.2022.3453