Investigation of 18F-FDG PET/CT Findings and CA-125 Levels in Ovarian Cancer Staging

SAGER, Sait; Akovali, Burak; Açıkgöz, Abdullah Serdar; AKYEL, RESIT; Kaya Döner, Zübeyde Rana; Sonmezoglu, Kerim; Şahin, Onur Erdem; Akgün, Elife

doi:10.5505/tjo.2022.3431

Investigation of 18F-FDG PET/CT Findings and CA-125 Levels in Ovarian Cancer Staging

RESIT AKYEL, (yedikule Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi, Nükleer Tıp Anabilim Dalı, İstanbul)

Elife AKGÜN, (Kırıkkale Yüksek İhtisas Hastanesi, Nükleer Tıp Anabilim Dalı, Kırıkkale, Türkiye)

Burak Akovali, (erzurum Bölge Eğitim ve Araştırma Hastanesi, Nükleer Tıp Anabilim Dalı, Erzurum,Türkiye)

Onur Erdem ŞAHİN, (sivas Numune Hastanesi, Nükleer Tıp Anabilim Dalı, Sivas, Türkiye)

MUHAMMET SAİT SAĞER, (istanbul Üniversitesi-Cerrahpaşa, Cerrahpaşa Tıp Fakültesi, Nükleer Tıp Anabilim Dalı, İstanbul)

Serdar AÇIKGÖZ, (İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Kadın Hastalıkları ve Doğum Anabilim Dalı, İstanbul,Türkiye)

Zübeyde Rana KAYA DÖNER, (Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Nükleer Tıp Anabilim Dalı, Bursa)

Kerim SONMEZOGLU (istanbul Üniversitesi-Cerrahpaşa, Cerrahpaşa Tıp Fakültesi, Nükleer Tıp Anabilim Dalı, İstanbul)

Türk Onkoloji Dergisi

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Yıl: 2022 Cilt: 37 Sayı: 2 Sayfa Aralığı: 174 - 181 Metin Dili: İngilizce DOI: 10.5505/tjo.2022.3431 İndeks Tarihi: 01-11-2022

Investigation of 18F-FDG PET/CT Findings and CA-125 Levels in Ovarian Cancer Staging

Öz:

OBJECTIVE This study aims are to investigate the role of 18F labeled fluoro-2-deoxy-D-glucose positron emission computed tomography/computed tomography (18F FDG PET/CT) in the initial staging and recurrence detection of ovarian cancer and to compare it with the cancer antigen-125 (CA-125) value. METHODS A total of 93 patients with a primary ovarian cancer diagnosis (Group 1 n=41) or suspicion of recurrent ovarian cancer (Group 2 n=52) were included in this study from January 2007 to January 2013. RESULTS The ages of the patients were between 15 and 82 years. In cases with PET positive lesions (n=84); Ovar- ian lesion (n=34), infradiaphragmatic lymph node metastasis (n=46), supradiaphragmatic lymph node metastasis (n=14), peritoneal implant (n=67), and distant metastasis (n=14) were detected. Histopatho- logical examination of 4 PET positive ovarian lesions was not compatible with cancer. In 14 cases with low CA-125 value, 18F FDG PET/CT was able to detect primary/recurrent lesions accurately. In the evaluation of primary/recurrent ovarian cancer, 18F FDG PET/CT had 93% sensitivity, 42.8% specific- ity, 89.2% accuracy, whereas CA-125 had 79.1% sensitivity, 42.8% specificity, and 76.3% accuracy. CONCLUSION In conclusion; even in low CA-125 values, 18F FDG PET/CT is a prominent method that can detect especially extra-abdominal distant metastatic foci in the initial staging of primary ovarian cancer and diagnosis and follow-up of recurrent ovarian cancer.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	AKYEL R, Akgün E, Akovali B, Şahin O, SAGER S, Açıkgöz A, Kaya Döner Z, Sonmezoglu K (2022). Investigation of 18F-FDG PET/CT Findings and CA-125 Levels in Ovarian Cancer Staging. , 174 - 181. 10.5505/tjo.2022.3431
Chicago	AKYEL RESIT,Akgün Elife,Akovali Burak,Şahin Onur Erdem,SAGER Sait,Açıkgöz Abdullah Serdar,Kaya Döner Zübeyde Rana,Sonmezoglu Kerim Investigation of 18F-FDG PET/CT Findings and CA-125 Levels in Ovarian Cancer Staging. (2022): 174 - 181. 10.5505/tjo.2022.3431
MLA	AKYEL RESIT,Akgün Elife,Akovali Burak,Şahin Onur Erdem,SAGER Sait,Açıkgöz Abdullah Serdar,Kaya Döner Zübeyde Rana,Sonmezoglu Kerim Investigation of 18F-FDG PET/CT Findings and CA-125 Levels in Ovarian Cancer Staging. , 2022, ss.174 - 181. 10.5505/tjo.2022.3431
AMA	AKYEL R,Akgün E,Akovali B,Şahin O,SAGER S,Açıkgöz A,Kaya Döner Z,Sonmezoglu K Investigation of 18F-FDG PET/CT Findings and CA-125 Levels in Ovarian Cancer Staging. . 2022; 174 - 181. 10.5505/tjo.2022.3431
Vancouver	AKYEL R,Akgün E,Akovali B,Şahin O,SAGER S,Açıkgöz A,Kaya Döner Z,Sonmezoglu K Investigation of 18F-FDG PET/CT Findings and CA-125 Levels in Ovarian Cancer Staging. . 2022; 174 - 181. 10.5505/tjo.2022.3431
IEEE	AKYEL R,Akgün E,Akovali B,Şahin O,SAGER S,Açıkgöz A,Kaya Döner Z,Sonmezoglu K "Investigation of 18F-FDG PET/CT Findings and CA-125 Levels in Ovarian Cancer Staging." , ss.174 - 181, 2022. 10.5505/tjo.2022.3431
ISNAD	AKYEL, RESIT vd. "Investigation of 18F-FDG PET/CT Findings and CA-125 Levels in Ovarian Cancer Staging". (2022), 174-181. https://doi.org/10.5505/tjo.2022.3431

APA	AKYEL R, Akgün E, Akovali B, Şahin O, SAGER S, Açıkgöz A, Kaya Döner Z, Sonmezoglu K (2022). Investigation of 18F-FDG PET/CT Findings and CA-125 Levels in Ovarian Cancer Staging. Türk Onkoloji Dergisi, 37(2), 174 - 181. 10.5505/tjo.2022.3431
Chicago	AKYEL RESIT,Akgün Elife,Akovali Burak,Şahin Onur Erdem,SAGER Sait,Açıkgöz Abdullah Serdar,Kaya Döner Zübeyde Rana,Sonmezoglu Kerim Investigation of 18F-FDG PET/CT Findings and CA-125 Levels in Ovarian Cancer Staging. Türk Onkoloji Dergisi 37, no.2 (2022): 174 - 181. 10.5505/tjo.2022.3431
MLA	AKYEL RESIT,Akgün Elife,Akovali Burak,Şahin Onur Erdem,SAGER Sait,Açıkgöz Abdullah Serdar,Kaya Döner Zübeyde Rana,Sonmezoglu Kerim Investigation of 18F-FDG PET/CT Findings and CA-125 Levels in Ovarian Cancer Staging. Türk Onkoloji Dergisi, vol.37, no.2, 2022, ss.174 - 181. 10.5505/tjo.2022.3431
AMA	AKYEL R,Akgün E,Akovali B,Şahin O,SAGER S,Açıkgöz A,Kaya Döner Z,Sonmezoglu K Investigation of 18F-FDG PET/CT Findings and CA-125 Levels in Ovarian Cancer Staging. Türk Onkoloji Dergisi. 2022; 37(2): 174 - 181. 10.5505/tjo.2022.3431
Vancouver	AKYEL R,Akgün E,Akovali B,Şahin O,SAGER S,Açıkgöz A,Kaya Döner Z,Sonmezoglu K Investigation of 18F-FDG PET/CT Findings and CA-125 Levels in Ovarian Cancer Staging. Türk Onkoloji Dergisi. 2022; 37(2): 174 - 181. 10.5505/tjo.2022.3431
IEEE	AKYEL R,Akgün E,Akovali B,Şahin O,SAGER S,Açıkgöz A,Kaya Döner Z,Sonmezoglu K "Investigation of 18F-FDG PET/CT Findings and CA-125 Levels in Ovarian Cancer Staging." Türk Onkoloji Dergisi, 37, ss.174 - 181, 2022. 10.5505/tjo.2022.3431
ISNAD	AKYEL, RESIT vd. "Investigation of 18F-FDG PET/CT Findings and CA-125 Levels in Ovarian Cancer Staging". Türk Onkoloji Dergisi 37/2 (2022), 174-181. https://doi.org/10.5505/tjo.2022.3431